Case Report

Kimura's disease: a neoplasm mimicking, a rare benign form of chronic inflammatory disorder

Harley Septian , Made Widhi Asih, Nyoman Srie Laksminingsih, Anak Agung Ayu Ngurah Susraini

Harley Septian
Radiology Resident, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia. Email: harley_W92@hotmail.com

Made Widhi Asih
Neuroradiologist, Radiology Department, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia

Nyoman Srie Laksminingsih
Consultant Radiologist, Radiology Department, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia

Anak Agung Ayu Ngurah Susraini
Anatomical Pathologist, Anatomical Pathology Department, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia
Online First: April 30, 2021 | Cite this Article
Septian, H., Asih, M., Laksminingsih, N., Susraini, A. 2021. Kimura's disease: a neoplasm mimicking, a rare benign form of chronic inflammatory disorder. Intisari Sains Medis 12(1): 463-466. DOI:10.15562/ism.v12i1.961


Background: Kimura's Disease (KD) is a benign, rare form of chronic inflammatory disease of unknown origin, almost exclusively found in Asian males in their second to fourth decades of life. This rare condition is mostly present as soft tissue mass consists of multiple painless solitary subcutaneous nodules mostly localized in the head and neck region, with coexisting lymph node enlargement and eosinophilia. This case study aims to describe Kimura's Disease (KD) characteristics and give an insight into the role of Computed Tomography (CT) scan in identifying KD and its imaging characteristics.

Case Presentation: We reported a case of an Asian man with a history of 18 years left-sided painless facial mass, gradually increase in size with no history of hoarseness, epistaxis, previous facial mass or malignancy, and familial malignancy. CT scan findings showed an inhomogeneous contrast enhancement soft tissue mass located on the left parotid-submandibular region with multiple neck lymphadenopathy and left parotid gland involvement. Eosinophilia was found persistently in the laboratory outcomes, and this mass had been confirmed with histological findings consistent with KD features.

Conclusion: Recognizing the characteristics of KD and the imaging findings on Ultrasound and CT-scan as accessible and first-line diagnostic tools, might help in facilitating the diagnosis, making a decision and sparing the patient from unnecessary and harmful procedures. 

References

Sia KJ, Kong CK, Tan TY, Tang IP. Kimura's Disease: Diagnostic Challenge and Treatment Modalities. Med J Malaysia. 2014;69(6):281-283.

AlGhamdi FE, Al-Khatib TA, Marzouki HZ, AlGarni MA. Kimura disease: No age or ethnicity limit. Saudi Med J. 2016;37(3):315-319.

Alshaikh AA, Musalem HM, Tuleimat LM, Alajlan SM. Kimura Disease: Rare Manifestations in Unusual Populations. Clin Dermatol J. 2017;2(3):1-4.

Osuch-Wójcikiewicz E, Bruzgielewicz A, Lachowska M, Wasilewska A, Niemczyk K. Kimura's Disease in a Caucasian Female: A Very Rare Cause of Lymphadenopathy. Case Rep Otolaryngol. 2014;2014:1-4.

Sun QF, Xu DZ, Pan SH, Ding JG, Xue ZQ, Miao CS, et al. Kimura disease: review of the literature. Intern Med J. 2008;38(8):668-72.

Choi JA, Lee GK, Kong KY, Hong SH, Suh JS, Ahn JM, et al. Imaging findings of Kimura's disease in the soft tissue of the upper extremity. AJR Am J Roentgenol. 2005;184(1):193-9.

Dhingra H, Nagpal R, Baliyan A, Alva SR. Kimura disease: case report and brief review of literature. Med Pharm Rep. 2019;92(2):195-199.

Buder K, Ruppert S, Trautmann A, Bröcker EB, Goebeler M, Kerstan A. Angiolymphoid hyperplasia with eosinophilia and Kimura's disease - a clinical and histopathological comparison. J Dtsch Dermatol Ges. 2014;12(3):224-228.

Abuel-Haija M, Hurford MT. Kimura disease. Arch Pathol Lab Med. 2007;131(4):650-651.

Gopinathan A, Tan TY. Kimura's disease: imaging patterns on computed tomography. Clin Radiol. 2009;64(10):994-999.


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