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Efektivitas tatalaksana tas-102 pada pasien kanker kolorektal metastasis


Background: Colorectal cancer is uncontrolled cell growth in the colon and rectum. On diagnosis, 20% of patients came with metastasis, and almost 50% will develop into one. On the third line and later, trifluridine/tipiracil (TAS-102) is available for metastatic colorectal cancer. This systematic review aimed to evaluate the efficacy of TAS-102 as monotherapy compared to a placebo or combined with bevacizumab.

Method: Systematic computer-based literature search for randomized controlled trials was conducted from Sept 23 until Oct 1, 2020, on PubMed and ASCO using the keywords (1)‘‘Metastatic Colorectal Cancer”, (2)‘‘TAS-102’’, (3)“management,” “treatment.” Results from the study were taken, such as overall survival and progression-free survival.

Results: From 225 articles on Pubmed and 62 from ASCO, 3 study articles from 2015 – 2020 that fit the inclusion criteria were taken. From 3 articles that match the inclusion criteria, the total population sample was 1299 colorectal cancer patients treated by TAS-102. Two studies compared TAS-102 and placebo showed that TAS-102 effectively increased overall and progression-free survival. The third article compared TAS-102 as monotherapy and, combined with bevacizumab, showed that TAS-102 was effective in improving overall survival and progression-free survival, and bevacizumab was able to increase the effects.

Conclusion: TAS-102 increased overall survival and progression-free survival in patients with metastatic colorectal cancer.


Latar Belakang: Kanker kolorektal adalah perkembangan sel-sel pada kolon dan rektum yang tidak terkontrol. Pada saat diagnosis, 20% pasien datang dengan keadaan metastasis dan hampir 50% akan berkembang menjadi metastasis. Pada lini ketiga atau lini lanjut, trifluridine/tipiracil (TAS-102) tersedia untuk pasien kanker kolorektal yang sudah bermetastasis. Systematic review ini bertujuan untuk mengevaluasi efektivitas TAS-102 pada beberapa penelitian yang meneliti TAS-102 sebagai monoterapi dibandingkan dengan plasebo atau dikombinasi dengan bevacizumab.

Metode: Pencarian literatur berupa randomized controlled trial dilakukan berbasis komputer pada tanggal 23 September 2020 hingga 1 Oktober 2020 di PubMed dan ASCO menggunakan kata kunci (1)‘‘Metastatic Colorectal Cancer”, (2)‘‘TAS-102’’, (3)“management”, “treatment”. Hasil artikel penelitian berupa overall survival dan progression-free survival kemudian dicatat.

Hasil: Hasil identifikasi 225 artikel dari Pubmed, 62 dari ASCO didapatkan 3 artikel yang memenuhi kriteria inklusi dan diambil dari kurun waktu tahun 2015 – 2020. Dari 3 artikel penelitian yang memenuhi kriteria inklusi, total populasi sampel 1299 dengan kanker kolorektal metastasis. Dua penelitian yang membandingkan tatalaksana TAS-102 dengan plasebo dan satu penelitian membandingkan TAS-102 sebagai monoterapi dan kombinasi TAS-102 dengan bevacizumab. Ketiga penelitian tersebut menunjukkan bahwa TAS-102 mampu meningkatkan overall survival dan progression-free survival.

Simpulan: TAS-102 mampu meningkatkan overall survival dan progression-free survival pada pasien kanker kolorektal yang sudah bermetastasis.


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How to Cite

Cassidy, C. A., Dewi, N. N. A., Sutadarma, I. W. G., & Wiryanthini, I. A. D. (2021). Efektivitas tatalaksana tas-102 pada pasien kanker kolorektal metastasis. Intisari Sains Medis, 12(3), 1058–1063.




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Christian Axel Cassidy
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Ni Nyoman Ayu Dewi
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I Wayan Gede Sutadarma
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Ida Ayu Dewi Wiryanthini
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