Hubungan faktor bakteriuria dan leukosituria dengan kejadian persalinan Preterm Premature Rupture of Membrane (PPROM) dan Premature Rupture of Membrane (PROM) di RSUD Mangusada, Badung tahun 2018-2019

I Gusti Ngurah Agung Trisnu Kamajaya; I Made Aryana; Anak Agung Ngurah Made Putra Wirawan

doi:10.15562/ism.v11i3.781

Hubungan faktor bakteriuria dan leukosituria dengan kejadian persalinan Preterm Premature Rupture of Membrane (PPROM) dan Premature Rupture of Membrane (PROM) di RSUD Mangusada, Badung tahun 2018-2019

I Gusti Ngurah Agung Trisnu Kamajaya ,

I Made Aryana ,

Anak Agung Ngurah Made Putra Wirawan ,

PDF |
DOI: https://doi.org/10.15562/ism.v11i3.781 |
Published: 2020-11-02

Abstract

Background: Preterm labor is one of the most contributors to morbidity and mortality in perinatal and neonatal. Several factors may cause preterm labor with infection as pathophysiology, including urinary tract infection (UTI), to initiate inflammation cascade. This study aims to determine the relationship between bacteriuria and leukocytic factors with the incidence of preterm premature rupture of membrane (PPROM) and premature rupture of membrane (PROM) delivery at Mangusada Hospital, Badung in 2018-2019.

Methods: A cross-sectional observational research toward 92 expectant within PPROM and 92 expectant within PROM was done to know the relation between leukocyturia and bacteriuria with the risk of PPROM and PROM. The research variable involves secondary data from urinalysis of leukocyturia and bacteriuria by flowcytometry Sysmex UX-2000 taken from the patientâ€™s registry at maternity room Mangusada Hospital, Badung in 2018-2019. Data were analyzed using SPSS version 17 for Windows.

Results: The study results show leukocyturia in PPROM is about 93.42% and 6.5% in PROM, while 71.67% bacteriuria within PPROM and 28.33% within PROM. Thereâ€™s no significant relationship between bacteriuria result in PPROM and PROM (p=0.247), but thereâ€™s considerable relation between leukocyturia within PPROM and PROM (p=0.000).

Conclusion: It can be concluded that thereâ€™s a significant relationship between leukocyturia within PPROM and PROM.

Latar Belakang: Persalinan preterm merupakan salah satu penyumbang besar morbiditas dan mortalitas perinatal dan neonatal. Berbagai faktor dapat menyebabkan persalinan preterm dengan mekanisme patofisiologi terutama infeksi, salah satunya infeksi saluran kemih (ISK), yang dapat menginisiasi kaskade inflamasi. Penelitian ini bertujuan untuk mengetahui hubungan faktor bakteriuria dan leukosituria dengan kejadian persalinan Preterm Premature Rupture of Membrane (PPROM) DAN Premature Rupture of Membrane (PROM) di RSUD Mangusada, Badung tahun 2018-2019

Metode: Penelitian observational cross-sectional terhadap 92 ibu hamil bersalin dengan PPROM dan 92 ibu dengan PROM dilakukan untuk mengetahui hubungan antara bakteriuria dan leukosituria dengan risiko terjadinya persalinan PPROM dan PROM. Variabel penelitian berupa data sekunder hasil urinanalisa flowcytometry Sysmex UX-2000 (leukosituria dan bakteriuria) diambil dari register pasien di ruang bersalin Rumah Sakit Daerah Mangusada Badung tahun 2018-2019. Data dianalisis dengan SPSS versi 17 untuk Windows.

Hasil: Hasil penelitian menunjukkan leukosituria pada PPROM sebanyak 93.42% dan 6.5% pada PROM, sedangkan bakteriuria sebanyak 71.67% pada PPROM dan 28.33% pada PROM. Tidak ada hubungan yang bermakna antara kejadian bakteriuria dengan persalinan PPROM dan PROM (p=0,247). Namun, ditemukan hubungan yang bermakna antara leukosituria dengan persalinan PPROM dan PROM (p=0,000).

Kesimpulan: Dapat disimpulkan terdapat hubungan signifikan antara leukosituria dengan persalinan PPROM dan PROM.

References

Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ. Outcomes for extremely premature infants. Anesth Analg. 2015;120(6):1337-1351.
Quinn JA, Munoz FM, Gonik B, Frau L, Cutland C, Mallett-Moore T, et al. Preterm birth: Case definition & guidelines for data collection, analysis, and presentation of immunisation safety data. Vaccine. 2016;34(49):6047-6056.
Purisch SE, Gyamfi-Bannerman C. Epidemiology of preterm birth. Semin Perinatol. 2017;41(7):387-391.
Stewart A, Graham E. Preterm birth: An overview of risk factors and obstetrical management. Dev Disabil Res Rev. 2010;16(4):285-288.
Nadeau HC, Subramaniam A, Andrews WW. Infection and preterm birth. Semin Fetal Neonatal Med. 2016;21(2):100-105.
Romero R, Oyarzun E, Mazor M, Sirtori M, Hobbins JC, Bracken M. Meta-analysis of the relationship between asymptomatic bacteriuria and preterm delivery/low birth weight. Obstet Gynecol. 1989;73(4):576-582.
Pamungkas AT. Perbandingan Angka Kejadian Bakteriuria dan Leukosituria antara Persalinan Aterm dan Preterm Studi kasus di RSUP Dr. Kariadi Periode 2013 [Skripsi]. Semarang: Balai Penerbit Universitas Diponegoro. 2014.
Fareid MA. Frequency and Susceptibility Profile of Bacteria Causing Urinary Tract Infections among Women. New York Science Journal. 2012;5(2):72.
Golan A, Wexler S, Amit A, Gordon D, David MP. Asymptomatic bacteriuria in normal and high-risk pregnancy. Eur J Obstet Gynecol Reprod Biol. 1989;33(2):101-108.
Sheiner E, Mazor-Drey E, Levy A. Asymptomatic bacteriuria during pregnancy. J Matern Fetal Neonatal Med. 2009;22(5):423-427.
Houston IB. Measurement of pyuria in urinary tract infections. Arch Dis Child. 1969;44(236):480-482.
Mochamad M, Ayu PK., The Relationship of Leukocyturia on The Incidence of Prominent Rupture of The Membrane in Preterm Pregnancy at The General Hospital of The University of Muhammadiyah Malang. Jurnal Saintika Medika. 2019;15(2):139-145.
Nuada IN, Karkata MK, Suastika K. Risiko Partus Prematurus Iminen pada Kehamilan dengan Infeksi Saluran Kemih. Cermin Dunia Kedokteran. 2004;145:26-30.
Gravett MG, Rubens CE, Nunes TM; GAPPS Review Group. Global report on preterm birth and stillbirth (2 of 7): discovery science. BMC Pregnancy Childbirth. 2010;10 Suppl 1(Suppl 1):S2.
Negara IKS, Surya IGP, Sanjaya H, Anantasika AAN, Mahardika IM. Lower Serum Catalase Level is Associated with Preterm Labor among Pregnant Women at Sanglah Hospital Denpasar, Bali-Indonesia. Bali Medical Journal. 2016;5(3):404-407.
Jannah M. Hubungan Infeksi Saluran Kemih pada Ibu Hamil terhadap Partus Prematurus di RSUD Dr. Adjidarmo Lebak Banten Periode Januari hingga Desember 2010 [Skripsi]. Banten: Universitas Islam Negeri Syarif Hidayatullah. 2011.
Dimetry SR, El-Tokhy HM, Abdo NM, Ebrahim MA, Eissa M. Urinary tract infection and adverse outcome of pregnancy. J Egypt Public Health Assoc. 2007;82(3-4):203-218.
Verma I, Avasthi K, Berry V. Urogenital infections as a risk factor for preterm labor: a hospital-based case-control study. J Obstet Gynaecol India. 2014;64(4):274-278.
Jain V, Das V, Agarwal A, Pandey A. Asymptomatic bacteriuria & obstetric outcome following treatment in early versus late pregnancy in north Indian women. Indian J Med Res. 2013;137(4):753-758.
McPheeters ML, Miller WC, Hartmann KE, et al. The epidemiology of threatened preterm labor: a prospective cohort study. Am J Obstet Gynecol. 2005;192(4):1325-1330.