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The low level of plasma vitamin C as a risk factor of preterm premature rupture of membrane

  • Muhammad Freddy Candra Sitepu ,
  • Ketut Suwiyoga ,
  • Anak Agung Ngurah Jaya Kusuma ,
  • I Gusti Putu Mayun Mayura ,
  • Made Darmayasa ,
  • I Wayan Artana Putra ,


Abstract

Introduction: Preterm premature rupture of membrane (PPROM) still becomes a problem related with perinatal morbidity and mortality which is caused by multifactorial risk factor; especially strength of foetal membrane. Collagen is the main component of foetal membrane’s extracellular matrix whereas plasma vitamin C roles as a collagen biosynthesis enzyme-dependent co-factor, down-regulator activity of MMP-1, MMP-2, and MMP-9 and also as antioxidant in remodelling and preventing structural damage extracellular matrix. The purpose of this study is to prove the low plasma level of vitamin C as a risk factor for PPROM on preterm pregnancy.

Method: This study was an analytical observational unpaired case-control performed from March 23rd until August 23rd 2018 at Polyclinic and Emergency Unit of Obstetrics and Gynaecology Sanglah Central General Hospital, Buleleng General Hospital, Mangusada General Hospital, Sanjiwani General Hospital, Wangaya General Hospital, and Prodia Clinical Laboratory Denpasar. The samples were preterm pregnancy women with premature rupture of membrane (PROM) as a case group and without premature rupture of membrane as a control group. The samples were taken from peripheral venous blood and level of plasma vitamin C is measured by HPLC method. The data were analysed by SPSS for Windows 20.0 version program then presented as table and narrative.

Result: Forty subjects were divided into 2 groups, 20 preterm pregnancy with PROM as a case group and 20 preterm pregnancy without PROM as a control group. Characteristic subject based on maternal age, gestational age, parity of both groups was 27.4 and 26.1 years old, 31 and 31 weeks, and also 1 and 1 time (p>0.05), not significantly different. The mean level of plasma vitamin C on case and control group were 3.90 ± 1.61 dan 9.24 ± 2.31 mg/L (p=0.001). On the case group the low level of plasma vitamin C was 51 times (OR= 51; CI 95% = 7.57–343.73; p=0,001) higher than the control group.

Conclusion: The low level of plasma vitamin C is a risk factor of PPROM.

Keywords: Vitamin C preterm premature rupture of membrane management

References

  1. Locatelli A, Andreani M, Ghidini A, Verderio M, Pizzardi A, Vergani P, et al. Amnioinfusion in preterm PROM: effects on amnion and cord histology. J Perinatol. 2008;28(2):97–101.
  2. Mercer B. Preterm premature rupture of the membranes. Obstetrics & Gynecology. 2003;101(1):178–93.
  3. Suwiyoga I, Budayasa A. The role of risk factors for premature rupture of membranes in the incidence of early neonatal sepsis in term pregnancy. Medicine World. 2006;151:14–7.
  4. Hadley C, Main D, Gabbe S. Risk Factors for Preterm Premature Rupture of the Fetal Membranes. Amer J Perinatol. 1990;7(04):374–9.
  5. Siega-Riz AM, Promislow JHE, Savitz DA, Thorp JM, McDonald T. Vitamin C intake and the risk of preterm delivery. American Journal of Obstetrics and Gynecology. 2003;189(2):519–25.
  6. Vadillo-Ortega F, González-Avila G, Karchmer S, Cruz NM, Ayala-Ruiz A, Lama MS. Collagen metabolism in premature rupture of amniotic membranes. Obstet Gynecol. 1990;75(1):84–8.
  7. Mathews F, Neil A. Antioxidants and preterm prelabour rupture of the membranes. BJOG: An International Journal of Obstetrics & Gynaecology. 2005;112(5):588–94.
  8. Okeke T, Enwereji J, Adiri C, Onwuka C, Iferikigwe E. Morbidities, concordance, and predictors of preterm premature rupture of membranes among pregnant women at the University of Nigeria Teaching Hospital (UNTH), Enugu, Nigeria. Niger J Clin Pract. 2016;19(6):737.
  9. Surya NK, Suwiyoga K, Arijana K, Tunas K. Role of Caspase-3 as Risk Factors of Premature Rupture of Membranes. Biomed Pharmacol J. 2017;10(4):2091–8.
  10. RC Medical College, Dist. Davangere – 577001, Karnataka, India, Patil DrS, Patil DrV. Maternal and Foetal Outcome in Premature Rupture of Membranes. IOSRJDMS. 2014;13(12):56–83.
  11. Joyce EM, Moore JJ, Sacks MS. Biomechanics of the Fetal Membrane Prior to Mechanical Failure: Review and Implication. Eur J Obstet Gynecol Reprod Biol;1441:S121-7.
  12. Strauss JF. Extracellular matrix dynamics and fetal membrane rupture. Reproductive Sciences. 2013;20(2):140-53.
  13. Plessinger MA, Wood JR. Jr Miller RK. Pretreatment of Human Amnion-Chorion with Vitamin C and E Prevents Hypochlorus Acid Induced Damage. Am J Obstet Gynecol. 2000;183(1):979-85.
  14. Sukhikh GT, Kan NE, Tyutyunnik VL, Sannikova MV, Dubova EA, Pavlov KA, et al. The Role of Extracellular Inducer of Matrix Metalloproteinases in Premature Rupture of Membranes. The Journal of Maternal-Fetal & Perinatal Medicine. 2015;12:1-5.
  15. Pfeffer F, Casanueva E, Kamar J, Guerra A, Perichart D, Vadillo-Ortega F. Modulation of 72-kilodalton type IV Collagenase (Matrix Metalloproteinase-2) by Ascorbic acid in Cultured Human Amnion-Derived Cells. Biol Repro. 1998;59:326-9.
  16. Vadillo-Ortega F, Pfeffer F, Bermejo ML, Hernandes MA, Beltran MJ, Tejero BE, Casanueva LE. Dietetic Factor and Premature Rupture of Fetal Membranes: Effect of Vitamin C on Collagen Degeneration in the Chorioamnion. Ginecologia y Obstetricia de Mexico. 1995;63:158-62.
  17. Richa S, Sumita M. Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes. The Journal of Obstetrics and Gynecology of India. 2014;64(6):417-20.
  18. Casanueva E, Ripoll C, Tolentino M, et al. Vitamin C Supplementation to Prevent Premature Rupture of the Chorioamniotic Membranes: A Randomized Trial. Am J Clin Nutri. 2005;81:859-63.
  19. Ghomian N, Hafizi L, Tahhti Z. The Role of Vitamin C in Prevention of Preterm Preterm Premature Rupture of Membranes. Iran Red Cres Med J. 2013;15(2):113-6.
  20. Rizka S, Ansori H, Effendi Y, Haryadi K, Zulkarnain M. Vitamin C Level in Pregnant Women with Premature Rupture of the Membrane (PROM) and in Women with Normal Pregnancy. Indones J Obstet Gynecol. 2011;35-4:173-5.
  21. Stuart EL, Evans GS, Lin YS, Powers HJ. Reduced Collagen and Ascorbic Acid Concentrations and Increased Proteolytic Susceptibility with Prelabor Fetal Membrane Rupture in Women. Biol Reprod. 2005;72:230-5.
  22. Sharma R, Mehta S. Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes. J Obstet Gynecol India. 2014;64(6):417–20.
  23. Osaikhuwuomwan JA, Okpere EE, Okonkwo CA, Ande AB, Idogun ES. Vitamin C plasma level and risk of preterm prelabour rupture of membranes. Arch Gynecol Obstet. 2011;284(3):593–7.

How to Cite

Sitepu, M. F. C., Suwiyoga, K., Kusuma, A. A. N. J., Mayura, I. G. P. M., Darmayasa, M., & Putra, I. W. A. (2020). The low level of plasma vitamin C as a risk factor of preterm premature rupture of membrane. Intisari Sains Medis, 11(2), 782–785. https://doi.org/10.15562/ism.v11i2.716
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Muhammad Freddy Candra Sitepu
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Ketut Suwiyoga
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Anak Agung Ngurah Jaya Kusuma
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I Gusti Putu Mayun Mayura
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Made Darmayasa
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I Wayan Artana Putra
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