Research Article

Efek pemberian ekstrak etanol bawang putih (Allium sativum) sebagai hepatoprotektor pada tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi parasetamol dosis hepatotoksik

Made Subhawa Harsa

Made Subhawa Harsa
Staff, Bagian Ilmu Faal Fakultas Kedokteran Universitas Wijaya Kusuma, Surabaya, Indonesia.. Email: madesubhawah@gmail.com
Online First: March 04, 2020 | Cite this Article
Harsa, M. 2020. Efek pemberian ekstrak etanol bawang putih (Allium sativum) sebagai hepatoprotektor pada tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi parasetamol dosis hepatotoksik. Intisari Sains Medis 11(1): 118-121. DOI:10.15562/ism.v11i1.666


Garlic (Allium sativum) is a plant that known to have various properties that can be used in treatment as a hepatoprotective agent. This study aim was to determine the effect of garlic ethanol extract (Allium sativum) in Wistar strain white male rats (Rattus norvegicus) which was induced by paracetamol in hepatotoxic dose. This research is an experimental study with randomized the post-test only control group design with sample consisted of twenty-four Wistar strain white male rats (Rattus norvegicus). The sample were divided into four groups: control groups, group P1 (given garlic ethanol extract 10 mg/kg), group P2 (ethanol extract of garlic was given 20 mg/kg) and group P3 (given the ethanol extract garlic 30 mg/kg). This study for seventeen days. The entire samples were terminated in order to draw blood to examine SGPT and SGOT. The data of SGPT and SGOT examined by One Way ANOVA. Result showed that there was significant difference in SGPT and SGOT values between groups after given ethanol extract of garlic (Allium sativum) (α <0.05). From the analysis we can concluded that garlic ethanol extract (Allium sativum) can be used as a hepatoprotective agent in Wistar strain white male rats (Rattus norvegicus)  induced by paracetamol in hepatotoxic dose.

References

Riyono A. Paracetamol Dalam Obat Anak-Anak. Poltekes Kementerian Kesehatan Surabaya. 2011

Wilmana PF, Sulistia G. Analgesik-Antipireutik, Analgesi-Anti Inflamasi Non Steroid, Dan Obat Gangguan Sendi Lainnya dalam Farmakologi dan Terapi edisi 5. Jakarta : FK UI. 2009: 237-239.

Darsono L. Diagnosis dan Terapi Intoksikasi Salisilat dan Parasetamol. Bandung : Universitas Kristes Maranatha. 2002

Murray MT, Pizzorno JE. Allium sativum (garlic). In: Textbook of natural and medicine. 2 Edition. (eds. J.E. Pizzorno Jr. and M.T. Murray). Edinburgh: Churchill Livingstone. 2009: pp. 571-577.

Sagita A. Pengaruh Ekstrak Andrographis paniculata (Sambiloto) Terhadap Kadar Serum Glutamat Oksaloasetat Transaminase Pada Tikus Wistar Yang Diberi Parasetamol. Fakultas Kedokteran Universitas Diponegoro Semarang. 2006

Chopra S. Patterns of Plasma Aspartate and Alanine Aminotransferase Levels with and Without Liver Disease. In: Kaplan MM, Bonis P, editors. Waltham, MA: UpToDate. 2008

Hernawan UE, Setyawan AD. Senyawa Organosulfur Bawang Putih Allium sativum L.) dan Aktivitas Biologisnya . Biofarmasi. 2003: 1 (1): 65-76.

Chiang YH et. al. Effects Of Garlic Oil And Two Of Its Major Organosulfur Compounds, Diallyl Disulfide And Diallyl Trisulfide, on Intestinal Damage in Rats Injected with Endotoxin. Toxicology and applied pharmacology. 2006: 213 (1): 46–54.

Pocock SJ. Clinical Trials A Practical Approach. England: John Miley & Son. 2008

Guyonnet D et. al. Mechanisms of Protection Against Aflatoxin B1 Genotoxicity in Rats Treated By Organosulfur Compounds from Garlic. Carcinogenesis 2002; 23:1335-1341.

Kumar S, Kumar A, Chandra A. Alteration in Serum Biochemical Parameters due to Garlic (Allium sativum) Supplementation in Broiler’s Diets. Afr. J. Biotechnology. 2013

Ryu KN, Matsura HI, Itakura Y. Nα-(1-deoxy-D-fructose-1-yl)-L- arginine, An Anti-Oxidant Compound Identified In Aged Garlic Extract. Journal of Nutrition 2001: 131: 972S–976S

Song K, Milner JA. The Influence Of Heating On The Anticancer Properties Of Garlic. Journal of Nutrition. 2001: 131: 1054S– 1057S

Sumioka I, Matsura T. Mechanisms of Protection by S-Allylmercaptocysteine Against Acetaminophen-Induced Liver Injury in Mice. Jpn J Pharmacol. 1998: 78(2):199-207.

Tanaka S et. al. Effects Of Aged Garlic Extract (AGE) on Colorectal Adenomas: A Double – Blinded Study. Hiroshima J Med Sci. 2004; 53: 39-45.

Banerjee SK. Maulik SK. Effect Of Garlic on Cardiovasculer Disorders: a review. Nutrition Journal. 2002: 1(4): 1–14.

Amagase H et. al. Intake Of Garlic And Bioactive Components. Journal of Nutrition. 2001: 131 (3): 955S– 962S.


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