Research Article

Hubungan antara Mean Platelet Volume (MPV) dengan klinis sepsis neonatorum di RSUD Wangaya, Bali, Indonesia

Stanley Haryono , I Wayan Bikin Suryawan, Anak Agung Made Widiasa

Stanley Haryono
Departemen Ilmu Kesehatan Anak, Rumah Sakit Umum Daerah (RSUD) Wangaya, Denpasar, Bali, Indonesia. Email: stanleyharyono@gmail.com

I Wayan Bikin Suryawan
Departemen Ilmu Kesehatan Anak, Rumah Sakit Umum Daerah (RSUD) Wangaya, Denpasar, Bali, Indonesia

Anak Agung Made Widiasa
Departemen Ilmu Kesehatan Anak, Rumah Sakit Umum Daerah (RSUD) Wangaya, Denpasar, Bali, Indonesia
Online First: August 01, 2020 | Cite this Article
Haryono, S., Suryawan, I., Widiasa, A. 2020. Hubungan antara Mean Platelet Volume (MPV) dengan klinis sepsis neonatorum di RSUD Wangaya, Bali, Indonesia. Intisari Sains Medis 11(2): 675-679. DOI:10.15562/ism.v11i2.646


Background: Neonatal sepsis is a disease that contributes significantly to infant morbidity and mortality, where the diagnosis is not specific to other diseases. In a state of sepsis, it is known that platelet production will increase due to the destruction of platelets so that there is a difference in platelet size or Mean Platelet Volume (MPV). This study aims to determine the relationship between MPV and clinical neonatal sepsis at Wangaya Hospital, Bali, Indonesia.

Methods: This study used a cross-sectional study design with 47 patients at Wangaya Hospital, Denpasar, in June-September 2019. The inclusion criteria were neonates with suspicion of sepsis, and the exclusion criteria were neonates who received previous antibiotic therapy, neonates who had previously received blood transfusions. , neonates with severe congenital anomalies were selected using a consecutive sampling technique. The sample was divided into 2 groups: clinical sepsis and non-clinical sepsis, MPV used a limit value of 10.2 fl, and data were analyzed by SPSS version 23 for Windows.

Results Most of the patients were male (66.7%), underwent section labor (77.8%), preterm birth (66.7%), birth weight (BBL) <2,500 grams (62.9%), and asphyxia (62.9%) in the non-septic group. Meanwhile, most of the sepsis group underwent labor (85%), preterm birth (70.0%), and asphyxia (75.0%). The results showed that there was a significant relationship between the MPV value and the risk of neonatal sepsis (RR: 8.16; 95% CI: 2.1-30.5; p = 0.003).

Conclusion: The results of this study concluded that there was a significant difference between the MPV value and the incidence of neonatal sepsis.

 

Latar Belakang: Sepsis neonatorum merupakan penyakit yang berkontribusi besar terhadap angka morbiditas dan mortalitas bayi dimana diagnosisnya bersifat tidak spesifik dengan penyakit lain. Pada keadaan sepsis, produksi trombosit diketahui akan meningkat akibat penghancuran trombosit sehingga adanya perbedaan ukuran trombosit atau Mean Platelet Volume (MPV). Penelitian ini bertujuan untuk mengetahui hubungan antara MPV dengan  klinis sepsis neonatorum di RSUD Wangaya, Bali, Indonesia.

Metode: Penelitian menggunakan rancangan penelitian potong lintang terhadap 47 pasien yang bertempat di RSUD Wangaya, Denpasar pada bulan Juni-September 2019. Kriteria inklusi adalah neonatus dengan kecurigaan sepsis dan kriteria ekslusi adalah neonatus yang mendapat terapi antibiotik sebelumnya, neonatus yang pernah menerima transfusi darah sebelumnya, neonatus dengan anomali kongenital berat yang dipilih menggunakan teknik consecutive sampling. Sampel dibagi menjadi 2 kelompok yaitu klinis sepsis dan bukan klinis sepsis, MPV menggunakan nilai batas 10,2 fl, dan data dianalisis dengan SPSS versi 23 untuk Windows.

Hasil Sebagian besar pasien berjenis kelamin laki-laki (66,7), menjalani persalinan seksio (77,8%), lahir preterm (66,7%), berat badan lahir (BBL) < 2.500 gram (62,9%), dan asfiksia (62,9%) pada kelompok tidak sepsis. Sedangkan pada kelompok sepsis sebagian besar menjalani persalinan seksio (85,%), lahir preterm (70,0%), dan asfiksia (75,0%). Hasil penelitian menunjukkan bahwa terdapat hubungan yang bermakna antara nilai MPV terhadap resiko terjadinya sepsis neonataroum (RR: 8,16; 95%IK: 2,1-30,5; p=0,003).

Kesimpulan: Hasil penelitian ini menyimpulkan bahwa terdapat perbedaan yang bermakna antara nilai MPV dengan kejadian sepsis neonatarum. 

References

Catal F, Tayman C, Tonbul A, Akca H, Kara S, Tatli MM, et al. Mean platelet volume (MPV) may simply predict the severity of sepsis in preterm infants. Clin Lab. 2014;60(7):1193-1200.

Kardana M. Incidence and factors associated with mortality of neonatal sepsis. Paediatrica Indonesiana 2011;51(3)144-8.

Wilar R, Antolis Y, Tatura SNN, Gunawan S. Jumlah trombosit dan mean platelet volume sebagai faktor prognosis pada sepsis neonatorum. Sari Pediatri. 2010;12(1):53-7.

Dharma BDA, Mulyantari NK, Prabawa IPY. Analisis korelasi kadar serum prokalsitonin dengan jumlah leukosit pada penderita dengan kecurigaan sepsis di RSUP Sanglah, Bali, Indonesia. Intisari Sains Medis. 2020;11(1):179-182.

Hanaganahalli SB, Sreeram S, Bompada M, Kuppannagari SK, Suresh PK, Philipose CS. Is MPV a Predictive Marker for Neonatal Sepsis? A Pilot Study. J Pediatr Hematol Oncol. 2018;40(7):548-552.

Prabawa IPY, Bhargah A, Liwang F, Tandio DA, Tandio AL, Lestari AAW, et al. Pretreatment Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as a Predictive Value of Hematological Markers in Cervical Cancer. Asian Pac J Cancer Prev. 2019;20(3):863-868.

Shalaby MM, Sobeih AA, Abdulghany WE, Behiry EG, Ismail YM, Abd-El-Aziz MA. Mean platelet volume and serum uric acid in neonatal sepsis: A case-control study. Ann Med Surg (Lond). 2017;20:97-102.

Van der Lelie J, Von dem Borne AK. Increased mean platelet volume in septicaemia. J Clin Pathol. 1983;36(6):693-696.

Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017;390(10104):1770-1780.

Bhat YR. Platelet indices in neonatal sepsis: a review. World J Clin Infect. 2017;7(1);6-10.

Prathyusha, Shreekrishna GN, Bhat S, Sahana P. Mean platelet volume (MPV) as a diagnostic marker in neonatal sepsis. Int J Contemp Pediatr. 2019;6(3):1036-40.

Aksoy HT, Eras Z, Guzoglu N, Canpolat FE, Dilmen U. Mean platelet volume is not associated with bacterial sepsis in newborns. Int J Infect Dis. 2013;17(12):e1263. doi:10.1016/j.ijid.2013.05.010

Cekmez F, Tanju IA, Canpolat FE, et al. Mean platelet volume in very preterm infants: a predictor of morbidities?. Eur Rev Med Pharmacol Sci. 2013;17(1):134-137.


No Supplementary Material available for this article.
Article Views      : 162
PDF Downloads : 63