Skip to main content Skip to main navigation menu Skip to site footer

The characteristics of neonatal sepsis in Low Birth Weight (LBW) infants at Sanglah General Hospital, Bali, Indonesia in 2018

Abstract

Background: Sepsis is one of the most common causes of mortality and long terms morbidity among infants. It is known to be related to Low Birth Weight (LBW) due to the lack of immunity function to resist the infection. This study aims to identify the characteristics of neonatal sepsis in LBW infants in Sanglah General Hospital.

Method: A retrospective cross-sectional study was conducted in the Neonatal Care Unit, Sanglah General Hospital, during January-December 2018 period among 135 neonates. Samples were taken using total sampling for neonates who had LBW and diagnosed with sepsis. Uncompleted data and voluntarily discharge patients were excluded from the study. Data regarding baseline characteristics of respondents, major and minor risk factors, laboratory results of sepsis, as well as blood culture, were analyzed using SPSS version 23 for Windows.

Result: Most of respondents were male (54.1%), followed by bodyweight 1,500-2,499 grams (58.5%), and preterm labor (<32 weeks) (86.7%). The average length of stay was 21.30±19.28 days. The vast majority of infants diagnosed as Early Onset Sepsis (EONS) (89.6%). Most of the patients had normal leukocyte count (93.3%), neutrophilia (95.6%), low I/T ratio (70.4%), normal platelets (67.4%), and high procalcitonin (98.5%). The blood culture showed the most microorganism was Enterococcus faecalis (6.00%) in gram-positive bacteria.

Conclusion: This study found that most of the respondents were male, followed by preterm labor, EONS, normal leukocyte count, low I/T ratio, high procalcitonin, as well as Enterococcus faecalis as the most common gram-positive bacteria. 

References

  1. Utomo MT. Neonatal Sepsis in Low Birth Weight Infants in Dr. Soetomo General Hospital. Indonesian Journal of Tropical and Infectious Disease. 2010;1(2):86-89.
  2. United Nations Children's Fund and World Health Organization. Low birthweight country, regional and global estimates. Switzerland: The United Nations Children's Fund and World Health Organization. 2004: p.1-27.
  3. Goldenberg RL, Culhane JF. Low birth weight in the United States. Am J Clin Nutr. 2007;85(2):584S-590S.
  4. Mahumud RA, Sultana M, Sarker AR. Distribution and Determinants of Low Birth Weight in Developing Countries. J Prev Med Public Health. 2017;50(1):18-28.
  5. Shah BA, Padbury JF. Neonatal sepsis: an old problem with new insights. Virulence. 2014;5(1):170-178.
  6. Hornik CP, Fort P, Clark RH, Watt K, Benjamin Jr DK, Manzoni P, et al. Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. Early Hum Dev. 2012;88 Suppl 2(Suppl 2):S69-S74.
  7. Aminullah A. Sepsis pada bayi baru lahir. Dalam: Kosim M, Yunanto A, Dewi R, Saroso GI, Usman A. Buku Ajar Neonatologi. Edisi 1. Jakarta: Badan Penerbit IDAI. 2008; p. 170-87.
  8. Hodgin KE, Moss M. The epidemiology of sepsis. Curr Pharm Des. 2008;14(19):1833-1839.
  9. Galiatsatos P, Brigham EP, Pietri J, Littleton K, Hwang S, Grant MC, et al. The effect of community socioeconomic status on sepsis-attributable mortality. J Crit Care. 2018;46:129-133.
  10. Short MA. Linking the sepsis triad of inflammation, coagulation, and suppressed fibrinolysis to infants. Adv Neonatal Care. 2004;4(5):258-273.
  11. Dharma BDA, Mulyantari NK, Prabawa IPY. Analisis korelasi kadar serum prokalsitonin dengan jumlah leukosit pada penderita dengan kecurigaan sepsis di RSUP Sanglah, Bali, Indonesia. Intisari Sains Medis. 2020;11(1):179-182.
  12. Aggarwal R, Sarkar N, Deorari AK, Paul VK. Sepsis in the newborn. Indian J Pediatr. 2001;68(12):1143-1147.
  13. Purtilo DT, Sullivan JL. Immunological bases for superior survival of females. Am J Dis Child. 1979;133(12):1251-1253.
  14. Lim WH, Lien R, Huang YC, Chiang MC, Fu RH, Chu SM, et al. Prevalence and pathogen distribution of neonatal sepsis among very-low-birth-weight infants. Pediatr Neonatol. 2012;53(4):228-234.
  15. Haque K. Neonatal Sepsis in the Very Low Birth Weight Preterm Infants: Part 2: Review of Definition, Diagnosis and Management. Journal of Medical Sciences. 2010;3(1):11-27.
  16. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110(2 Pt 1):285-291.
  17. Ashraif M, Haq M, Ashraf W, Ahmed F. Early Onset Neonatal Sepsis in Preterm Premature Rupture of The Membrane. Pak Armed Forces Med J. 2015;65(2):226-230.
  18. Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B; Israel Neonatal Network. Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: a national survey. Clin Infect Dis. 2005;40(2):218-224.
  19. Hornik CP, Benjamin DK, Becker KC, Benjamin DK, Li J, Clark RH, et al. Use of the complete blood cell count in early-onset neonatal sepsis. Pediatr Infect Dis J. 2012;31(8):799-802.
  20. de Rueda Saiguero OODR, Mosquera JN, Gonzalez MB, Crespo MJR, de Soria COL. Cord blood procalcitonin in the assessment of early onset neonatal sepsis. A Pediatr. 2017;87(2):87-94.
  21. Peng CT, Lin HC, Wang DW, Tsai CH. Degnerative changes in neutrophils as an indicator of neonatal sepsis. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1989;30(5):309-315.
  22. Meirina F, Lubis B, Sembiring T, Siregar O. Hematological scoring system as an early diagnostic tool for neonatal sepsis. Paediatrica Indonesiana. 2015;55(6):315-321.

How to Cite

Suismaya, N. L. G. W., & Artana, I. W. D. (2020). The characteristics of neonatal sepsis in Low Birth Weight (LBW) infants at Sanglah General Hospital, Bali, Indonesia in 2018. Intisari Sains Medis, 11(2), 669–674. https://doi.org/10.15562/ism.v11i2.639

HTML
177

Total
210

Share

Search Panel

Ni Luh Gede Wahyuni Suismaya
Google Scholar
Pubmed
ISM Journal


I Wayan Dharma Artana
Google Scholar
Pubmed
ISM Journal