Research Article

Analysis of serum albumin levels in pre and post hemodialysis among Chronic Renal Failure (CRF) patients at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia

Marini Kala Tanan , Fitriani Mangarengi, Mutmainnah Mutmainnah

Marini Kala Tanan
Medical Doctor Specialist Education Program of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Email: marinikt@yahoo.com

Fitriani Mangarengi
Department of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Syekh Yusuf Gowa Hospital, Makassar, Indonesia

Mutmainnah Mutmainnah
Department of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia
Online First: August 01, 2020 | Cite this Article
Tanan, M., Mangarengi, F., Mutmainnah, M. 2020. Analysis of serum albumin levels in pre and post hemodialysis among Chronic Renal Failure (CRF) patients at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Intisari Sains Medis 11(2): 466-469. DOI:10.15562/ism.v11i2.599


Background: Chronic renal failure (CRF) is a clinical syndrome caused by a chronic decrease and gradual progression in kidney function. One of the complications of CRF can cause hypoalbuminemia. Hemodialysis can also cause hypoalbuminemia associated with inflammation and malnutrition due to loss of protein during dialysis. This study aims to analyze the albumin levels in pre and post hemodialysis CRF patients in Dr. Wahidin Sudirohusodo Hospital, Makassar.

Methods: A retrospective study with cross sectional study design using secondary data obtained from the medical record was conducted among 50 patients at Dr. Wahidin Sudirohusodo Hospital, Makassar. Pre and post hemodialysis serum albumin levels of CRF patients from the Medical Record Installation were collected during September 2017 – 2018 period. Variables assessed in this study were gender, age, albumin levels, and the comparison of albumin levels based on gender. Data were analyzed using SPSS version 22 for Windows.

Results: There were 52.0% male and 48.0% of female patients in this study. Most of the respondents were age 40-49 years old interval (30.0%). There was no significant difference in albumin levels between pre (3.07±0.63 g/dL) and post (3.05±0.54 g/dL) HD patients (p=0.665). Also, There was no significant difference in albumin levels in pre and post HD patients between male (p=0.434) and female (p=0.778).

Conclusion: There were no significant differences between serum albumin levels pre and post hemodialysis in patients with CRF as well as based on gender.

References

Webster AC, Nagler EV, Morton RL, Masson P. Chronic Kidney Disease. Lancet. 2017;389(10075):1238-1252.

Fraser SD, Blakeman T. Chronic kidney disease: identification and management in primary care. Pragmat Obs Res. 2016;7:21-32.

Hill NR, Fatoba ST, Oke JL, et al. Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis. PLoS One. 2016;11(7):e0158765.

McClellan WM. Epidemiology and risk factors for chronic kidney disease. Med Clin North Am. 2005;89(3):419-445.

Prodjosudjadi W. Incidence, prevalence, treatment and cost of end-stage renal disease in Indonesia. Ethn Dis. 2006;16(2 Suppl 2):S2-16.

Stanifer JW, Muiru A, Jafar TH, Patel UD. Chronic kidney disease in low- and middle-income countries. Nephrol Dial Transplant. 2016;31(6):868-874.

Himmelfarb J, Ikizler TA. Hemodialysis. N Engl J Med. 2010;363(19):1833-1845.

Anees M, Ibrahim M. Anemia and hypoalbuminemia at initiation of hemodialysis as risk factor for survival of dialysis patients. J Coll Physicians Surg Pak. 2009;19(12):776-780.

Haller C. Hypoalbuminemia in renal failure: pathogenesis and therapeutic considerations. Kidney Blood Press Res. 2005;28(5-6):307-310.

Levitt DG, Levitt MD. Human serum albumin homeostasis: a new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion, and the clinical value of serum albumin measurements. Int J Gen Med. 2016;9:229-255.

Lee JS. Albumin for end-stage liver disease. Korean J Intern Med. 2012;27(1):13-19.

Pupim LB, Flakoll PJ, Ikizler TA. Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients. Eur J Clin Nutr. 2007;61(5):686-689.

Gatta A, Verardo A, Bolognesi M. Hypoalbuminemia. Intern Emerg Med. 2012;7 Suppl 3:S193-S199. doi:10.1007/s11739-012-0802-0

Arinta, Rihiantoro T, Hardono. Peningkatan Kadar Albumin pada Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisis. Jurnal Ilmu Kesehatan. 2016;1(1); 1-7

Majid RA. Perbedaan Kadar Albumin Pasien Penyakit Ginjal Kronik Stadium 5 yang Telah Menjalani dan Belum Menjalani Hemodialisis Rutin di RSUD Dr. Moewardi. [Skripsi] Universitas Muhammadiyah Surakarta. 2018;1-19

Don BR, Kaysen G. Serum albumin: relationship to inflammation and nutrition. Semin Dial. 2004;17(6):432-437.

Nowak KL, Chonchol M. Does inflammation affect outcomes in dialysis patients?. Semin Dial. 2018;31(4):388-397.


No Supplementary Material available for this article.
Article Views      : 41
PDF Downloads : 25