Research Article

Korelasi jenis dan lama waktu pemberian obat antituberkulosis paru terhadap kadar glukosa darah di RSUP Sanglah periode 2015-2016

Gde Dicky Arimbawa , Ni Kadek Mulyantari

Gde Dicky Arimbawa
Program Studi Pendidikan Dokter, Fakultas Kedokteran Universitas Udayana, Bali-Indonesia. Email: dicky_arimbawa@yahoo.com

Ni Kadek Mulyantari
Departemen/KSM Patologi Klinik, Fakultas Kedokteran, Universitas Udayana-Rumah Sakit Umum Pusat Sanglah, Denpasar, Bali-Indonesia
Online First: December 01, 2019 | Cite this Article
Arimbawa, G., Mulyantari, N. 2019. Korelasi jenis dan lama waktu pemberian obat antituberkulosis paru terhadap kadar glukosa darah di RSUP Sanglah periode 2015-2016. Intisari Sains Medis 10(3). DOI:10.15562/ism.v10i3.449


Background: Tuberculosis (TB) is a chronic infectious disease caused by an infection of the Mycobacterium tuberculosis complex. Antituberculosis (OAT) drugs used in TB treatment include Isoniazid (H), Rifampicin (R), Pyrazinamide (Z), Ethambutol (E), and Streptomycin (S). The effects of OAT use are many that are hepatotoxic. This hepatotoxic disrupts liver function as a very important glucose buffer system. The purpose of this study was to determine the correlation of the type and duration of administration of OAT to blood glucose levels at Sanglah Hospital.

Method: This study is an analytical study with a cross sectional study design. The population in this study were tuberculosis patients who were treated at Sanglah General Hospital, Denpasar in March 2015 - October 2016. The selection of samples used consecutive sampling with a total sample of 38.

Results: The correlation test results between the duration of OAT administration and blood glucose levels in tuberculosis patients at Sanglah General Hospital using the spearman test obtained a correlation coefficient (r) value of 0.536 so that according to statistics it can be concluded that there is a positive correlation between the length of time OAT is to blood glucose concentrations. The correlation test between the type of OAT on blood glucose levels in tuberculosis patients in Sanglah General Hospital used the chi-square test obtained P value is 0.133 so according to statistics it can be concluded that there was no significant relationship between the type of OAT to blood glucose concentrations in tuberculosis patients at Sanglah Hospital.

Conclusion: There is a significant positive correlation between the duration of OAT treatment of blood sugar levels, but there is no relationship between the type of OAT to blood sugar levels in patients with pulmonary tuberculosis.

References

Amin Z, Bahar A. Tuberkulosis Paru. dalam: Setiati S, Alwi I, Sudoyo AW, editor. Ilmu Penyakit Dalam edisi ke-6. Jakarta: Interna Pub; 2011. p. 863-881.

Departemen Kesehatan RI. Pharmaceutical Care Untuk Penyakit Tuberkulosis [Internet]. Jakarta: Depkes RI; 2005 [Diakses: 10 Januari 2017]. Tersedia di: http://farmalkes.kemkes.go.id/en/2013/11/pharmaceutical-care-untuk-penyakit-tuberkulosis/.

Da Silva V, Tigeh S, Wirawan N, Bakta M. The Relationship Between Education, Job, and Family Income with TB Medication Dropouts in Timor-Leste. Bali Medical Journal. 2016;5(2):279-282. DOI:10.15562/bmj.v5i2.223

Ramatillah DL, Suhartini S, et al. The Evaluation of Drug Related Problems (DRPs) of the Tuberculosis (TB) Patients at the Lung Disease Ward in the Installation of Stayed Caring of Central General Hospital Persahabatan (RSUP Persahabatan). World J Pharmaceutical Research. 2014;3(4):14-23.

Adriztina I, Adnan A, et al. Gangguan Pendengaran dan Keseimbangan pada Pendengaran dan Keseimbangan pada Penderita Tuberkulosis yang Mendapat Pengobatan Antituberkulosis Kategori 1 dan 2. Jurnal Kesehatan Masyarakat Nasional. 2014;8(8):43-48.

Cahyadi A, Venti L. Tuberkulosis Paru pada Pasien Diabetes Mellitus. J Indon Med Assoc. 2011;61(4):32-37.

Widhiartini I, Wirasuta M, Sukrama D, Rai I. Therapeutic drug monitoring of rifampicin, isoniazid, and pyrazinamide in newly-diagnosed pulmonary tuberculosis outpatients in Denpasar area. Bali Medical Journal. 2019;8(1):107-113. DOI:10.15562/bmj.v8i1.1304

Guyton AC, & Hall JE. Insulin, Glukagon, dan Diabetes Melitus. In : Tanzil, A. (ed) Fisiologi Kedokteran Edisi ke-12. Jakarta: Penerbit Buku Kedokteran EGC; 2011. p. 1015-1026.

Prameswari AI. Hubungan Tuberkulosis pada Diabetes Melitus [Skripsi]. Jakarta : Universitas Indonesia; 2013.

Kuswibawati L. Pengaruh Pemberian Rifampisin Terhadap Efek Hipoglikemik Glipizid pada Relawan Sehat. Majalah Farmasi Indonesia. 2013;14(2):299-305.

Ruslami R, Nijland HMJ, et al. Pharmacokinetics of Antituberculosis Drugs in Pulmonary Tuberculosis Patient with Type 2 Diabetes. American Society for Microbiology. 2010;54(3):1068-1074.


No Supplementary Material available for this article.
Article Views      : 5
PDF Downloads : 1