Skip to main content Skip to main navigation menu Skip to site footer

Hipertensi sebagai prediktor kejadian kardiovaskular mayor pada pasien infark miokard akut pada tahun 2018 di RSUP Sanglah Denpasar, Bali-Indonesia



Abstract

Introduction: Acute Myocardial Infarction (AMI) is a leading cause of morbidity and mortality in developed countries, as well as emerged as a very important health problem in developing countries. Despite of management and treatment of AMI strategies has been evolving. Complications due to AMI cause high morbidity and mortality. To minimalize complications in AMI patients need some risk stratification. Risk stratification have been made based on AMI pathophysiology. Hypertension is a factor that directly influences the development of atherosclerosis through mechanical stress.

Method: This study was a retrospective cohort observational study that enrolled 70 patients with AMI as the subject of research by consecutive sampling from January 2018 – September 2018. Data retrieval is done by taking data from medical records of patients in the Sanglah General Hospital. Outcome observed was in-hospital MACE (cardiovascular death, cardiogenic shock, heart failure, and malignant arrhythmias).

Result: In this study, it was found that hypertension is a predictor of major cardiovascular events by almost 5-fold (HR = 5,02, 95% CI = 1,32-19,20, p = <0.018in patients with AMI that were treated at Sanglah General Hospital.

Conclusion: The conclusion of this study is hypertension is a predictor of major cardiovascular events in patients with AMI on admission to hospital. The results of this study are expected to be used as baseline data for subsequent larger studies.

Keywords: hypertension acute myocardial infarction major adverse cardiovascular events

References

  1. Benjamin E, Emelia J, Michael JB, Stephanie EC. Heart Disease and Stroke Statistics—2017 Update. A Report From the American Heart Association. Circu;lation. 2017;135:e146-e603.
  2. Mullasari AS, Balaji P, Khando T. Managing complications in acute myocardial infarction. J Assoc Physicians India.. 2011;59(Suppl1):43-48.
  3. Gerber Y, Susan AW, Maurice ES, Cecilia B, Alanna M. Chamberlain SM, Ruoxiang J, Shannon MD, Véronique LR. Mortality Associated With Heart Failure After Myocardial Infarction A Contemporary Community Perspective. Circ Heart F. 2016;9(1):e002460.
  4. de Araújo GP, Ferreira J, Aguiar C, Seabra GR. TIMI, PURSUIT, and GRACE risk scores: sustained prognostic value and interaction with revascularization in NSTEâ€ACS. European Heart Journal. 2005;26(9):865-872.
  5. Price SA, Wilson LM, editor. Patofisiologi: konsepklinis prosesproses penyakit Edisi ke-6, Volume 1. Jakarta: Penerbit Buku Kedokteran EGC; 2006.
  6. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206-52.
  7. Brown CT, Penyakit aterosklerotik koroner. Dalam: terjemahan Hartanto H. Price SA, Wilson LM, editor. Patofisiologi, Konsep Klinis Proses-Proses Penyakit. Edisi ke-6. Jakarta: EGC; 2006.
  8. Dewi MR, Haryati DS, Sumardino. Faktor -Faktor Dominan Sindrom Metabolik Yang Berhubungan Dengan Kejadian Akut Miokard Infark (AMI) di ruang Intensive Cardiovasculer Care Unit (ICVCU) RSUD Dr. Moewardi Tahun 2014. Jurnal KesMaDaSka. 2014;67:105–116.
  9. Kang DG, Myung HJ, Yongkeun A, et al. Clinical Effects of Hypertension on the Mortality of Patients with Acute Myocardial Infarction. J Korean Med Sci. 2009;24:800-6.
  10. O’Rourke MF, Hashimoto J. Mechanical factors in arterial aging: a clinical perspective. J Am Coll Cardiol. 2007;50:1–13.
  11. Millar JA, Lever AF. Implications of pulse pressure as a predictor of cardiac risk in patients with hypertension. Hypertension. 2000;36:907–911.
  12. Park HW, et al. Long-term Prognosis and Clinical Characteristics of Patients with Newly Diagnosed Diabetes Mellitus Detected after First Acute Myocardial Infarction: from KAMIR-NIH Registry. Korean Circulation Journal. 2018;48(2):134-147.
  13. Lee MG, Myung HJ, Ki HL, et al. Prognostic Impact of Diabetes Mellitus and Hypertension for Mid-term Outcomeof patient with Acute Myocardial Infarction who Underwent Percutaneus Coronary Intervention. J Cardiol. 2012;60:257-263.
  14. Huang Y, Cai X, Li Y, et al. 2014. Prehypertension and the risk of stroke: a meta-analysis. Neurology. 2014;82(13):1153-61.
  15. Parodi,Guido, Nazario Carrabba, Giovanni M., et al. Heart Failure and Left Ventricular Remodeling After Reperfused Acute Myocardial Infarction in Patients With Hypertension. Hypertension. 2006;47:257-263.
  16. Julius S. Sympathetic hyperactivity and coronary risk in hypertension. Hypertension. 1993;21(6):886–893.
  17. Djohan T. Penyakit jantung koroner dan hipertensi [Internet]. Sumatera Utara: e-USU Repository; 2006 [Diakses 10 Agustus 2018]. Tersedia di: http://repository.usu.ac.id/bitstream/handle/123456789/705/08E00124.pdf;jsessionid=8FE08473AD19EB9F35D3086733F351EA?sequence=1.
  18. Reinstadler SJ, Thomas S, Charlotte E, et al. Antecedent hypertension and myocardial injury in patients with reperfused STelevation myocardial infarction. Journal of Cardiovascular Magnetic Resonance. 2016;18(1):1-8.
  19. Pertiwi GAR, Aryawangsa AAN, Prabawa IPY, Manuaba IBAP, Bhargah A, Budiana IPG. Factor associated with visit-to-visit variability of blood pressure in hypertensive patients at primary health care service, Tabanan, Bali, Indonesia. FMCH. 2018;6(4):191-199. DOI: https://doi.org/10.15212/FMCH.2018.0124.
  20. Handoyo V, Pertiwi GAR, Prabawa IPY, Manuaba IBAP, Bhargah A, Budiana IPG. Management of ST-elevation myocardial infarction in the setting of anterior epistaxis: focused on antiplatelet and antithrombotic therapies. International Journal of Medical Case Report. 2019;12:33-38. DOI: http://dx.doi.org/10.2147/IMCRJ.S189370.

How to Cite

Kirthi, A. A. A. K., Yasmin, A. A. A. D. A., Artha, I. M. J. R., & Bhargah, A. (2019). Hipertensi sebagai prediktor kejadian kardiovaskular mayor pada pasien infark miokard akut pada tahun 2018 di RSUP Sanglah Denpasar, Bali-Indonesia. Intisari Sains Medis, 10(3). https://doi.org/10.15562/ism.v10i3.443
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
926

Total
3189

Share

Search Panel

A A Ayu Kaivalya Kirthi
Google Scholar
Pubmed
ISM Journal

A. A. Ayu Dwi Adelia Yasmin
Google Scholar
Pubmed
ISM Journal

I Made Junior Rina Artha
Google Scholar
Pubmed
ISM Journal

Agha Bhargah
Google Scholar
Pubmed
ISM Journal