Research Article

Disregulasi IL-17, CD4 neutrofil, IL-10, PGE-2, iNOS, dan MMP-9 di jaringan kulit terhadap kerusakan saraf dermal pada pasien erythema nodusum leprosum

I Gusti Nyoman Darmaputra , Cita Rosita Sigit Prakoeswa, Anang Endaryanto, IGAA Elis Indira, Nyoman Suryawati, Evy Ervianti, Linda Astari, Bagus Bagus

I Gusti Nyoman Darmaputra
Fakultas Kedokteran Universitas Airlangga Program Studi Ilmu Kedokteran Jenjang Doktor Bagian/SMF Ilmu Kesehatan Kulit dan Kelamin Fakultas Kedokteran Universitas Udayana Rumah Sakit Umum Pusat Sanglah Denpasar. Email: darmaputrakulit@yahoo.com

Cita Rosita Sigit Prakoeswa
Ilmu Kedokteran Jenjang Profesi Doktor, Fakultas Kedokteran Universitas Airlangga

Anang Endaryanto
Ilmu Kedokteran Jenjang Profesi Doktor, Fakultas Kedokteran Universitas Airlangga

IGAA Elis Indira
Bagian/SMF Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran Universitas Udayana/Rumah Sakit Umum Pusat Sanglah Denpasar

Nyoman Suryawati
Bagian/SMF Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran Universitas Udayana/Rumah Sakit Umum Pusat Sanglah Denpasar

Evy Ervianti
Ilmu Kedokteran Jenjang Profesi Doktor, Fakultas Kedokteran Universitas Airlangga

Linda Astari
Ilmu Kedokteran Jenjang Profesi Doktor, Fakultas Kedokteran Universitas Airlangga

Bagus Bagus
Ilmu Kedokteran Jenjang Profesi Doktor, Fakultas Kedokteran Universitas Airlangga
Online First: August 01, 2019 | Cite this Article
Darmaputra, I., Sigit Prakoeswa, C., Endaryanto, A., Elis Indira, I., Suryawati, N., Ervianti, E., Astari, L., Bagus, B. 2019. Disregulasi IL-17, CD4 neutrofil, IL-10, PGE-2, iNOS, dan MMP-9 di jaringan kulit terhadap kerusakan saraf dermal pada pasien erythema nodusum leprosum. Intisari Sains Medis 10(2). DOI:10.15562/ism.v%vi%i.441


Introduction: The mechanism of nerve damage in ENL patients is important to be revealed because the problem of nerve damage is not getting enough attention in handling ENL patients. Some pro-inflammatory mediators that have been studied are risk factors for nerve damage in ENL.

Aim: This study aim in knowing the mechanism of nerve damage in the relation with its risk factors, which are CD64 neutrophil, IL-17, MMP-9, and iNOS with PGE-2 and IL-10 protective factor and IL-10 in ENL patients.

Method: This is an analytic cross-sectional design study with tissue samples from 30 leprosy patients with ENL in Dr. Soetomo General Hospital Surabaya. Samples from biopsy examined using IHC method to evaluate S-100, IL-10, IL-17, PGE-2, iNOS, MMP-9, and CD64 neutrophil expressions. The result calculated within 20 view field with 1000 times magnification.

Result: CD64 neutrophil (p=0.022, r=-0.417), IL-17 (p=0.001, r=-0.560), iNOS (p=0.005, r=-0.502) and MMP-9 (p=0.025, r=-0.409) has significant correlation with S-100. There is no significant correlation between IL-10 (p=0.061) and PGE-2 (p=0.407) with S-100.

Conclusion: Expressions of IL-17, CD64 neutrophil, MMP-9, and iNOS in tissue correlate with nerve damage in ENL patients.

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