Research Article

Perbedaan manifestasi klinis dan laboratorium kolestasis intrahepatal dengan ekstrahepatal pada bayi di RSUP Sanglah Denpasar periode Januari 2015 - Desember 2018

Pande Putu Agung Willa Kesawa Putra , IGN Sanjaya Putra, I Nyoman Budi Hartawan

Pande Putu Agung Willa Kesawa Putra
Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Udayana, Bali-Indonesia. Email: pandekesawaputra@gmail.com

IGN Sanjaya Putra
Departmen/KSM Ilmu Kesehatan Anak, Fakultas Kedokteran, Universitas Udayana, Balli-Indonesia

I Nyoman Budi Hartawan
Departmen/KSM Ilmu Kesehatan Anak, Fakultas Kedokteran, Universitas Udayana, Balli-Indonesia
Online First: September 02, 2019 | Cite this Article
Putra, P., Putra, I., Hartawan, I. 2019. Perbedaan manifestasi klinis dan laboratorium kolestasis intrahepatal dengan ekstrahepatal pada bayi di RSUP Sanglah Denpasar periode Januari 2015 - Desember 2018. Intisari Sains Medis 10(3). DOI:10.15562/ism.v10i3.440


Introduction: Physiological jaundice found in infants and most symptoms are often mild. In conjugated jaundice defects in intra-hepatic production, transmembran transport from bile, i.e. cholestasis intrahepatic, or extra-hepatic obstruction/cholestasis occur, resulting in bile barriers. This study was conducted to look at the differences in the clinical and laboratory manifestations of IH and EH cholestasis in infants.

Method: A descriptive retrospective study was performed on 102 infants with cholestasis who came to Sanglah Hospital Denpasar, during the period of January 2015 – December 2018. Data analysis was performed with pearson Chi-square test and independent t-test.

Result: Subjects consisted of 60 infants boys and 42 infant girls, intrahepatic cholestasis were 79 and extra-trahepatic cholestasis were 42. Significant differences in characteristic of nutritional status with intrahepatic and extra-hepatic cholestasis were found (p=0,015), but there isn’t significant differences in age, birth weight, gestational age were observed. On examination of stool color, there was a significant difference (p<0,001), as well as laboratory results of SGOT, SGPT (p<0,05) between intra and extra-hepatic cholestasis. Meanwhile there isn’t significant differences in GGT, total bilirubin, direct bilirubin, indirect bilirubin, and ALP.

Conclusions: There were differences in the characteristics of nutritional status, differences in laboratory results of SGOT, SGPT, and fecal clinics between intrahepatic and extrahepatic cholestasis.

References

Kusumawati, dkk. 2012. Aspartat Amino Transferase-Platelet Ratio Index (APRI), Kadar Bilirubin dan Venektasi Penderita Kolestasis Anak di RSUP dr. Kariadi Semarang. Jawa Tengah: Media Medika Indonesia. 2012; 46(1): 57-61

Modha K. Clinical approach to patients with obstructive jaundice. Tech Vasc Interv Radiol. 2015.;18(4):197-200.

Arief S. Deteksi Dini Kolestasis Neonatal (Early Detection of Neonatal Cholestasis) [Internet]. Surabaya: Divisi Ilmu Kesehatan Anak FK Unari; 2006 [Diakses 10 Januari 2018]. Tersedia di: https://dokumen.tips/documents/deteksi-dini-penyebab-kolestasis-pada-bayi.html.

Karyana IPG, Putra IGNS, Yanti NPVK. Kolestasis pada Sepsis Neonatorum di RSUP Sanglah, Denpasar. Sari Pediatri. 2012;14(4):211-217.

Gaur K, Sakhuja P. Progressive familial intrahepatic cholestasis: a comprehensive review of a challenging liver disease. Indian J Pathol Microbiol. 2017;60(1):2-7.

Prasetyo D, Ermaya YS, Martiza I. Perbedaan manifestasi klinis dan laboratorium kolestasis intrhepatal dengan ekstrahepatal pada bayi. MKB. 2016;48(1):45-50.

Young S, Azzam R. Infatile cholestasis: approach and diagnostic algoritm. Textbook of pediatric gastroenterology, hepatology, and nutrition: a comprehensive guide to practice. Philadelphia: Saunders; 2016.

Omer M, Khattak TA, Shah SHA, Manzoor K. Etiological spectrum of persistent neonatal jaundice. JMRC. 2010;14(2):87-9

Urganci N, Cetinkaya F, Kalyoncu D, Cakir EDP. Infants with cholestasis:diagnosis, management, and outcome. Marmara Med J. 2012;2(1):83-6.

Bhatia, dkk. 2014. Management of neonatal cholestasis. Academy of Pediatrics. Indian Pediatrics. 2014;51:203-10.

Singh P, Khan S, Mittal R. Prevalence of jaundice based on liver function test in western nepal. Bali Medical Journal. 2013;2(2):72-74.


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