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Pengaruh waktu simpan Packed Red Cells (PRC) terhadap perubahan kadar hemoglobin, hematokrit, dan glukosa plasma di RSUP H. Adam Malik, Medan, Indonesia

  • Pesalmen Saragih ,
  • Ida Adhayanti ,
  • Zulfikar Lubis ,
  • Herman Hariman ,

Abstract

Background: Someone who approves the PRC must have been transfused no more than 24 hours after the creation of the PRC; some also apply 3 days. But there are also those that apply up to 1 week. PRC is still feasible to be transfused immediately by seeing changes that occur in the value of hemoglobin (Hb), hematocrit (Ht), and plasma needed when storing.

Methods: 30 whole blood bags (WB) were taken for this study. The WB is at the request of the doctor for the manufacture of PRC. The blood bag is rotated at a speed of 4,000 RPM for 15 minutes. From the PRC, 3 cc of blood was taken on 1,3,5,7 days for hemoglobin (Hb), hematocrit (Ht), and glucose plasma. Data were analyzed using SPSS version 21 software for Windows.

Results: After 1-day taking 3 cc of blood, PRC was stored at 4 ° C, and then 3cc was taken also on days 3, 5, 7. The results showed that hemoglobin (Hb), hematocrit (Ht) increased from day 1 until day 7 but not significant (P> 0.05), plasma plasma showed a decrease from day 1 to day 7 and significant (P <0.001) but the value was still within normal limits. Correlation value between Hb and PRC retention time; r = 0.127, Ht with the shelf life of PRC, r = 0.160, plasma glucose with the length of time the PRC is stored; r = -0,844.

Conclusion: PRC stored for 7 days is still feasible to use. There was a decrease in plasma glucose but still within normal limits.

References

  1. Saraswati KD, Purwanto B, Suparyatmo JB. Pengaruh Waktu Simpan Darah terhadap Kadar Laktat Dehidrogenase pada Packed Red Cells Tehnik Penyimpanan Darah Dengan Citrate Phosphate Dextrose – Saline Adenine Glucose Manitol. [Thesis]. Universitas Sebelas Maret. Surakarta. 2015.
  2. Lestari AAW, Triyono T, Sukoroni U. Quality of stored red blood. Indonesian Journal of Clinical Pathology and Medical Laboratory. 2017; 23(3):294-302
  3. Fuada R, Sulung N, Juwita LV. Perbedaan Rekasi Pemberian Transfusi Darah Whoole Blood (WB) dan Packed Red Cell (PRC) Pada Pasien Sectio Secarea. Jurnal Human Care. 2016; 1(3):1-9
  4. Harmening DM, Firestone D. The ABO blood group system. Modern Blood Banking & Transfusion Practices. In: Harmening DM, editor. 5th ed. Philadelphia: F.A. Davis Company; 2005: 108–33.
  5. Hajjawi OS. Glucose transport in human red blood cells. American Journal of Biomedical and Life Sciences. 2013; 1(3):44-52
  6. Simons AL, Mattson DM, Dornfeld K, Spitz DR. Glucose deprivation-induced metabolic oxidative stress and cancer therapy. J Cancer Res Ther. 2009;5 Suppl 1:S2-6.
  7. Safitri M. Perbedaan Kadar Gula Darah pada Serum yang Langsung Diperiksa dan Ditunda Selama 24 jam pada Suhu Kamar. [Thesis]. Analis Kesehatan Fakultas Ilmu Keperawatan dan Kesehatan Universitas Muhammadiyah, Semarang. 2009
  8. Fergusson D, Hutton B, Hogan DL, LeBel L, Blajchman MA, Ford JC, et al. The age of red blood cells in premature infants (ARIPI) randomized controlled trial: study design. Transfus Med Rev. 2009; 23(1):55-61.
  9. Pettilä V, Westbrook AJ, Nichol AD, Bailey MJ, Wood EM, Syres G, et al. Age of red blood cells and mortality in the critically ill. Crit Care. 2011;15(2):R116.
  10. Lacroix J, Hébert PC, Fergusson DA, Tinmouth A, Cook DJ, Marshall JC, et al. Age of transfused blood in critically ill adults. N Engl J Med. 2015; 372(15):1410-8.
  11. Roback JD. Vascular effect of the red blood cell storage lesion. Hematology Am Soc Hematol Educ Program. 2011;2011:475-9.
  12. Karon BS, Buskirk CMV, Jaben EA, Hoyer JD, Thomas DD. Temporal sequence of major biochemical events during blood bank storage of packed red blood cell. Blood Transfus. 2012; 10(4):453-61
  13. Spinelli SL, Lannan KL, Casey AE, Croasdell A, Curan TM, Henrichs KE et al. Isoprostane and isofuran lipid mediators accumulate in stored red blood cell concentrates and influence platelet function in vitro. Transfusion. 2014; 54(6): 1569–1579.
  14. Barer AP. A study of glycolysis. J Clin Invest. 1931; 10(3): 507–520.
  15. Sowemimo-Coker SO. Red blood cell hemolysis during processing. Transfus Med Rev. 2002; 16(1):46-60.
  16. Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, et al. Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation. 2011; 124(4):465-76.
  17. Hess JR, Sparrow L, Van der mer PF, Acker JP, Cardigan RA, Devine DV. Red blood cell hemolysis during blood bank storage: using national quality management data to answer basic scientific questions. Transfusion. 2009; 49(12):2599-603.

How to Cite

Saragih, P., Adhayanti, I., Lubis, Z., & Hariman, H. (2019). Pengaruh waktu simpan Packed Red Cells (PRC) terhadap perubahan kadar hemoglobin, hematokrit, dan glukosa plasma di RSUP H. Adam Malik, Medan, Indonesia. Intisari Sains Medis, 10(2). https://doi.org/10.15562/ism.v10i2.415

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