Research Article

Entitas histopatologi penderita perdarahan uterus terkait gangguan hormonal di Laboratorium Patologi Anatomi Rsup Sanglah tahun 2014 -2018

Ida Ayu Eugenia Natasha Blanco Oka , IGA Sri Mahendra Dewi, Herman Saputra, Indraguna Pinatih, Indraguna Pinatih

Ida Ayu Eugenia Natasha Blanco Oka
Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Udayana, Bali-Indonesia. Email: eugeniaoka.9f@gmail.com

IGA Sri Mahendra Dewi
Bagian Patologi Anatomi, Fakultas Kedokteran, Universitas Udayana-RSUP Sanglah Denpasar, Bali-Indonesia

Herman Saputra
Pathology Anatomy Department, Sanglah General Hospital, Bali-Indonesia

Indraguna Pinatih
Bagian Patologi Anatomi, Fakultas Kedokteran, Universitas Udayana-RSUP Sanglah Denpasar, Bali-Indonesia

Indraguna Pinatih
Bagian DKM-KP, Fakultas Kedokteran, Universitas Udayana, Bali-Indonesia
Online First: August 01, 2019 | Cite this Article
Blanco Oka, I., Dewi, I., Saputra, H., Pinatih, I., Pinatih, I. 2019. Entitas histopatologi penderita perdarahan uterus terkait gangguan hormonal di Laboratorium Patologi Anatomi Rsup Sanglah tahun 2014 -2018. Intisari Sains Medis 10(2). DOI:10.15562/ism.v10i2.383


Introduction: Dysfunctional uterine bleeding (DUB) is a major cause of a significant burden of health care for women, their families, and the community as a whole, leading to high morbidity for women who experience it. The purpose of this study is to determine the prevalence, characteristics of patients, and histopathological description in patients with DUB. Method: This study uses a secondary data analysis method in the medical record data of patients with DUB who has been histopathologically examined at the Anatomy Pathology Laboratory, Sanglah General Hospital Denpasar in the period 2014 to 2018.Result: From the period 2014 to 2018, 24 cases of DUB were found, the highest number was found in the pre menopause age (41-50 years) in 15 cases (62.5%), based on the type of estrogen related bleeding hormonal disorders in 17 cases (70.8%), and 7 cases of progesterone related bleeding (29.2%). The most histopathological type in the estrogen related bleeding group was 13 disordered proliferative phases (54.2%). In the group with progesterone related bleeding, the highest histopathological picture was irregular shedding in 5 cases (20.8%).Conclusion: Estrogen related bleeding pattern still dominating the histopatological pattern in the dysfunctional uterine bleeding at Pathology Anatomy Laboratory, Sanglah General Hospital period 2014-2018.

References

Fraser IS, Langham S. Health-related quality of life and economic burden of abnormal uterine bleeding. Expert Rev Obstet Gynecol. 2009;4:179–89.

Hendarto H. Gangguan Haid/Perdarahan Uterus Abnormal. In: Mochammad Anwar, Ali Baziad, R. Prajitno Prabowo, editors. Ilmu Kandungan (3rd ed). Jakarta; PT Bina Pustaka Sarwono Prawirohardjo, 2011. p. 162-9.

Doraiswami S, Thanka J, Shalinee R, Aarthi R, Jaya V, Kumar PV. Study of endometrial pathology in abnormal uterine bleeding. The Journal of Obstetrics and Gynecology of India. 2011;61(4):426-430.

Deligeoroglou E, Karountzos, V, Creatsas G. Uterine Bleeding in Pediatric and Adolescent Gynecology. Gynecological Endocrinology. 2013;29(1):74-78.

Gray SH, Emans SJ. Abnormal vaginal bleeding in adolescents. Pediatr Rev. 2007;28:175–182.

Mazur M, and Kurman RJ. Diagnosis of endometrial biopsies and curettings: a practical approach. Arch J Med Sci. 2005;3(2):18-23.

Khadim MT, Zehra T, Ashraf HM. Morphological study of pipelle biopsy specimens in cases of abnormal uterine bleeding. J Pak Med Asoc. 2015;65(7):705-709.

Bulleti C, Flamigni C, Prefetto RA, Polli V, Giacomucci E. Dysfunctional uterine bleeding (DUB). Annals New York Academy of Science. 2011;6(2):80-90.

Bertrand ND. Dysfunctional uterine bleeding: relation of endometrial histology to outcome. Amer J Obstet Gynecol. 2008;109(1):103-107.

Rekha K, Malini A, Xavier R, Baba K. Apoptosis in endometira of dysfunctional uterine. Med J Malaysia. 2004;60(1):41-45.

Espindola D, Kathleen AK, Fischer EG. Management of abnormal uterine bleeding and the pathology of endometrial hyperplasia. Obstet Gynecol Clin N Am. 2007;34:717-737.

Adnyana IBP, Liwang F, Negara KS, Manuaba IBP, Bhargah A, Prabawa IPY. Clinical risk factor of preeclampsia: a five-year retrospective study in Bali Royal Hospital, Bali-Indonesia. Gineco.eu. 2018;14(53):89-93. DOI: 10.18643/gieu.2018.89.

Megadhana I, Suwiyoga K. Stage III-IV Uterine Prolapse Risk Factors: Sacrouterine Ligaments High Estrogen Receptor Alpha and Collagen III Expression and Low Elastin Expression. Bali Medical Journal. 2016;5(1):91-97. DOI:10.15562/bmj.v5i1.275


No Supplementary Material available for this article.
Article Views      : 213
PDF Downloads : 105