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Perbandingan Kadar NT-proBNP Serum Pasien PGK eGFR <60 Pre- Dialisis dengan dan tanpa Gagal Jantung di RSUD DR Soetomo Surabaya


Background: N-terminal-proBNP (NT-proBNP) is one of the most important biomarkers in diagnosing heart failure (HF). The excretion of NT-proBNP is affected by the decline of kidney function, thus the interpretation of serum levels of NT-proBNP in chronic kidney disease (CKD) patients to diagnose HF needs to be assessed carefully. Therefore, the purpose of this study is to investigated the difference between NT-proBNP levels in CKD patient with and without heart failure.

Method: This observational analytic with cross-sectional study examined primary data of the serum level of NT-proBNP in predialyzed CKD patients with and without HF in outpatient clinic in Dr. Soetomo hospital, Surabaya between August and September 2018. Kidney function in predialyzed patients were classified into five stages using the Cockcroft Gault formula of estimated glomerular filtration rate (eGFR). Patients with eGFR <60mL/min/1.73m2 were included in this study. The differences between NT-proBNP levels in predialyzed CKD patients with and without heart failure were then analyzed using univariate and bivariate analysis.

Results: The study population consisted of 50 predialyzed CKD patients which include 25 patients with HF and 25 patients without HF. The NT-proBNP mean in HF patients was [23,082 pg/mL (22,413)] and in patients without HF was [815 pg/mL (651)]. There was significant difference in NT-proBNP level between patients with HF and without HF (p<0,001).

Conclusion: This study showed that there was significant increase in NT-proBNP level of predialyzed CKD patients with HF compare to patients without HF.


  1. Spanaus K, Eckardstein A. Natriuretic Peptides In Cardiac And Renal Failure. Pippete Magz. 2007;P6-10.
  2. Srisawasdi P, Vanavanan S, Charoenpanichkit C, Kroll. The Effect of Renal Dysfunction on BNP, NT-proBNP, and Their Ratio. Am J Clin Pathol. 2010:133:14-23.
  3. Anwarudin S, Lloyd-Jones M, Boggish A, Chen A, Krauser D, Tung R, Chae C, Januzzi J. Renal Function, CHF, And Amino Terminal BNP Measurement. J Am Coll Cardiol. 2006:47(1): P91-97.
  4. Park M, Vittinghof E, Shlipale M, Misra R, Whooley M, Bansal N. Association of N-Terminal Pro-B-Type Natriuretic Peptide with Kidney Function Decline in Persons Without Clinical Heart Failure in The Heart and Soul Study. Am Heart J. 2014:168: 931-939
  5. Takase H, Dohi Y. Kidney function crucially affects B-type natriuretic peptide (BNP), N-terminal proBNP and their relationship. Eur J Clin Invest. 2014;44(3):303-8.
  6. European Society of Cardiology (ESC). Heart Failure Guidelines. 2016. Diunduh dari :
  7. Lullo L, Gorini A, Russo D, Santoboni A, Ronco C. Left Ventricular Hyperthrophy In CKD Patients: From Pathophysiology To Treatment. Cardiorenal Med. 2015:5: P254-266
  8. Taddei S, Nami R, Bruno R, Quatrini H, Nuti R. Hypertension, Left Ventricular Hyperthrophy And Chronic Kidney Disease. Heart Fail Rev. 2011:16: P615-620.
  9. Cho Y. Diastolic Dysfunction And CKD. Korean J Intern Med. 2012:28: P22-26
  10. Tzatzaki E, Spartalis M, Kamperialis V, Spartalis E, Giannakulais G, Karvounis H, 2017. Diastolic Dysfunction In ESRD Patients. Hell J Nucl Med. 2017;8: P96-102.
  11. David S, Kumpers P, Seidler V, Biertz F, Haller H, Fliser D. Diagnostic Value of NT-proBNP for Left Ventricular Dysfunction in Patients with Chronic Kidney Disease Stage 5 on Haemodialysis. Nephrol Dial Transplant. 2008. 23: 1370-1377.
  12. Mishra R, Li Y, Ricardo A, Yang W, Keane M, Cuevas M, Et Al. Association Of NT Pro-BNP With Left Ventricular Structure And Function In CKD Am J Cardiol. 2013:111(3): P432-438
  13. Wiley C, Switzer S, Berg R, Glurich I, Dart R. Association Of BNP Levels With Egfr And Congestive Heart Failure. J Clin Med Res. 2010:8(1): P7-12.

How to Cite

Puspita, M. P., Widodo, W., & Subagio, A. (2019). Perbandingan Kadar NT-proBNP Serum Pasien PGK eGFR <60 Pre- Dialisis dengan dan tanpa Gagal Jantung di RSUD DR Soetomo Surabaya. Intisari Sains Medis, 10(3).




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