Research Article

Hubungan kadar troponin I dan high-sensitivity troponin I dengan angiografi koroner pada pasien suspek coronary artery disease: studi di Rumah Sakit Umum Pusat dr.Wahidin Sudirohusodo Makassar-Indonesia tahun 2017

Dessy Iriana , Asvin Nurulita, Darmawaty Rauf

Dessy Iriana
Program Pendidikan Dokter Spesialis Patologi Klinik, Fakultas Kedokteran Universitas Hasanuddin/RSUP dr.Wahidin Sudirohusodo Makassar, Indonesia. Email: dessyiriana19@gmail.com

Asvin Nurulita
Program Studi Patologi Klinik, Fakultas Kedokteran, Universitas Hasanuddin/ RSUP dr.Wahidin Sudirohusodo Makassar, Indonesia

Darmawaty Rauf
Program Studi Patologi Klinik, Fakultas Kedokteran, Universitas Hasanuddin/ RSUP dr.Wahidin Sudirohusodo Makassar, Indonesia
Online First: August 01, 2019 | Cite this Article
Iriana, D., Nurulita, A., Rauf, D. 2019. Hubungan kadar troponin I dan high-sensitivity troponin I dengan angiografi koroner pada pasien suspek coronary artery disease: studi di Rumah Sakit Umum Pusat dr.Wahidin Sudirohusodo Makassar-Indonesia tahun 2017. Intisari Sains Medis 10(2). DOI:10.15562/ism.v10i2.373


Background: Coronary artery disease (CAD) is a narrowing of blood vessels due to the formation of atherosclerotic plaques which can cause disruption of oxygen supply to the heart. High sensitivity troponin I (hs-TnI) is a diagnostic tool for detecting heart disorders with minimal injury to the heart muscle.

Aim: The study aimed to compare and observe the relationship of troponin I (TnI) and hsTnI with /RSUP dr.Wahidin  Sudirohusodo Makassar.

Methods: The design of the study was cross-sectional study, using primary data of blood samples from 31 suspected CAD patients who underwent coronary angiography examination at RSUP Dr.Wahidin Sudirohusodo Makassar. Samples were taken from a population of subjects who met the inclusion criteria by using consecutive sampling technique in the period of September 2018. Statistical analysis were done using descriptive statistical calculations, frequency distribution and, Spearman’s correlation test. The test results were considered significant if p<0.05.

Results: CAD was more common in men at the age of 50-69 years. Data analysis showed a significant correlation between TnI, hsTnI, and the degree of stenosis (p<0.001). The correlation coefficient of TnI and degree of stenosis was 0.707, hsTnI with degree of stenosis was 0.877, and TnI with hsTnI was 0.804.

Conclusion: Higher levels of TnI and hsTnI are related to the severity of stenosis in CAD.

References

Benjamin EJ, Blaha MJ, Chiuve SE, Cruhman M, Das SR et al. Heart Disease and Stroke Statistics-2017 update: a report from the American Heart Association. Circulation. 2017; 35(10):e146-e603.

Beltrame JF, Dreyer R and Tavella R. Epidemiology of of Coronary Artery Disease. In David Gaze (Ed.), Coronary Artery Disease - Current Concepts in Epidemiology, Pathophysiology, Diagnostics and Treatment. DOI: 10.5772/29030. 2013. Available from: https://www.intechopen.com/books/coronary-artery-disease-current-concepts-in-epidemiology-pathophysiology-diagnostics-and-treatment/epidemiology-of-coronary-artery-disease

Riset Kesehatan Dasar (Riskesdas). Badan Litbangkes, Depkes RI. Jakarta; 2013;91.

Cesar LA, Ferreira JF, Armaganijan D, Gowdak LH, Mansur Ap et al. Guidelines For Stabel Coronary Artery Disease. Arq Brass Cardiol. 2014;103(2 Supl 2):1-56.

Coldea LA, Cionca C and Lupu S. 2015. Coronary CT Angiography and the Napkin-ring Sign Indicates High-Risk Atherosclerotic Lessions. In Kaan Kirali (Ed.), Coronary Artery Disease: Assesment, Surgery, Prevention. 2015. DOI: 10.5772/61393. Available from: https://www.intechopen.com/books/coronary-artery-disease-assessment-surgery-prevention/coronary-ct-angiography-and-the-napkin-ring-sign-indicates-high-risk-atherosclerotic-lesions

Tahhan AS, Sandesara P, Hayek SS, Hammadah M, Alkhoder A et al. High-Sensitivity TroponinI Levels and Coronary Artery Disease Severity, Progression, and Long-Term Outcomes. J Am Heart Assoc. 2018;7:e007914.

Kumar R and Ahmad MI. High sensitive troponin as biomarker for coronary artery disease. J Clin Cardiolog. 2017;8:2.

Samsu N. Sensitivitas dan spesifisitas troponin T dan I pada diagnosis infark miokard akut. Maj Kedokt Indon. 2007;57(10):363-71.

Borren N, Angela HEM, and Ottervanger JP. Stop invasive coronary angiography as the gold standard for dignosis of stable angina. Interv Cardiol 2015;7(5):1-4.

Jomansyah MUA. Angiografi koroner. CDK-207. 2013;40(8):626-8.

Ford I, Anoop SV, Zhang R, McAllister, Stachan FE et al. High-Sensitivity Cardiac Troponin, Statin Therapy, and Risk of Coronary Heart Disease. Jounal of the American Collage of Cardiology. 2016;68(25): 2719.

Iribarren C, Chandra M, Rana JS, Hlatky MA, Fortmann SP et al. High-Sensitivity Cardiac Troponin I and Incident Coronary Heart Disease Among Asymptomatic Older Adults. Heart. 2016;102:1177-82.

Tsioufis C, Mantzouranis E, Kalos T, Konstantinidis D, Tousoulis D. Risk Factors of Atherosclerosis: Pathophysiological Mechanisms. In Dimitris Tousoulis, Coronary Artery Disease From Biology to Clinical Practice. Elsevier Inc. 2018.


No Supplementary Material available for this article.
Article Views      : 18
PDF Downloads : 13