Research Article

Efek latihan kesamaptaan terhadap kadar D-Dimer pada anggota militer Kodam I Bukit Barisan

R. Prathama Wiradharma , Nizam Zikri Akbar, Adi Koesoema Aman

R. Prathama Wiradharma
Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Sumatera Utara/RSUP H. Adam Malik, Medan, Indonesia. Email:

Nizam Zikri Akbar
Departemen Kardiologi dan Kedokteran Vaskular, Fakultas Kedokteran Universitas, Sumatera Utara / RSUP H. Adam Malik, Medan, Indonesia

Adi Koesoema Aman
Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Sumatera Utara/RSUP H. Adam Malik, Medan, Indonesia
Online First: August 01, 2019 | Cite this Article
Wiradharma, R., Akbar, N., Aman, A. 2019. Efek latihan kesamaptaan terhadap kadar D-Dimer pada anggota militer Kodam I Bukit Barisan. Intisari Sains Medis 10(2). DOI:10.15562/ism.v10i2.363

Background: Several reports and experiences show that when doing heavy exercise often occur complaints which direct the diagnosis towards Venous Thrombo-Embolism (VTE) in the form of painful and swollen feet. This was due to hypercoagulation and resulted in VTE. The D-dimer level is a measure of clot formation and lysis resulting from the breakdown of fibrinogen and fibrin during fibrinolysis. Therefore this study aimed to see an increase in D-Dimer which is a marker of increased fibrinolysis.

Method: This study took a sample of blood from 30 soldiers who were declared healthy. The sample was checked for D-Dimer 1 hour before and after the test. The physical readiness test is a standard for assessing the readiness of soldiers in carrying out tasks. The sample was evaluated whether there was an increase after the test. Examination using Coatron machine with the Immuno Turbidimetric Assay method.

Result: 30 people are men with an average age of 19-22 years. D-Dimer showed a significant difference with a mean of 92.83 ± 49.62 SD before the test and after the test found a mean of 127.53 ± 57.75 SD with p = 0.001 (p <0.05).

Conclusion: The increase in D-Dimer shows an increase in blood coagulation processes and fibrinolysis and can occur in individuals who often carry out heavy activities. D-Dimer and Dopler ultrasound screening should be carried out on a periodic check before carrying out the physical readiness test.


Rooney KD, Schilling UM. Point-of-care testing in the overcrowded emergency department can it make a difference? Crit Care. 2014;18:1-7

White R. The epidemiology of venous thromboembolism. Circulation. 2003;107:1-5

ISTH Steering Committee for World Thrombosis Day. Thrombosis: a major contributor to global disease burden. J Thromb Haemost. 2014; 12: 1580–90

JCS Guidelines. Guidelines for the diagnosis, treatment and prevention of pulmonary thromboembolism and deep vein thrombosis. Circ J. 2011;75: 1258-81

Sudrajat Y. Kajian tes kesegaran jasmani “A” bagi personel kategori usia 50 tahun ke atas. Dispenad. 2014

Kevin SK. The effect of exercise on D-dimer levels. Military Medicine. 2014;179:225

Kupchak BR, Volk BM, Kunces LJ, Kraemer WJ, Hoffman MD, Phinney SD, Volek JS. Alterations in coagulatory and fibrinolytic systems following an ultra-marathon. Eur J Appl Physiol. 2013;113:2705–12

Hui SK, Mast A. D-dimer: a non-invasive test for patients with suspected DVT. Clin Lab News. 2009

Wells PS, Anderson DR, Rodger M, Forgie M, Keron C,Dreyer J, et al. Evaluation of d-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med. 2003. 349:1227–35

Stralen KJ, Le Cessie S, Rosendaal FR, Doggen CJ. Regular sports activities decrease the risk of venous thrombosis. J Thromb Haemost. 2007; 5:2186–92

Posthuma JJ, Meijden PE, Cate HT, Spronk HM. Short- and long-term exercise induced alterations in haemostasis: a review of the literature. Blood Rev. 2015;2:171–8

Bergeron MF, Nindl BC, Deuster PA. Consortium for health and military performance and american college of sports medicine consensus paper on extreme conditioning programs in military personnel. Curr Sports Med Rep. 2011;10:383–9

Adam SS, Key NS, Greenberg CS. D-dimer antigen: current concepts and future prospects. Blood. 2013;113:2878–87

Sand KL, Flatebo T, Andersen MB, Maghazachi AA. Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males. World J Exp Med. 2013;3:11–20

Womack CJ, Nagelkirk PR, Coughlin AM. Exercise-induced changes in coagulation and fibrinolysis in healthy populations and patients with cardiovascular disease. Sports Med. 2003;33:795–807

Kupchak BR, Volk BM, Kunces LJ, Kraemer WJ, Hoffman MD, Phinney SD, et al. Alterations in coagulatory and fibrinolytic systems following an ultramarathon. Eur J Appl Physiol. 2013;113:2705–12

Parker BA, Augeri AL, Capizzi JA, Ballard KD, Kupchak BR, Volek JS, et al. Effect of marathon run and air travel on pre- and post-run soluble d-dimer, microparticle procoagulant activity, and p-selectin levels. Am J Cardiol

; 109:1521–5

Kathleen M, Thomas H. Blood coagulation and fibrinolysis in healthy, untrained subjects: effects of different exercise intensities controlled by individual anaerobic threshold. Eur J Appl Physiol. 2011;111:253–60

Papadaki M, Ruef J, Nguyen KT, Li F, Patterson C, Eskin SG, et al Differential regulation of protease activated receptor-1 and tissue plasminogen activator expression by shear stress in vascular smooth muscle cells. Circ Res. 1998; 83:1027–34.

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