Research Article

Analisis rasio netrofil limfosit dan rasio platelet limfosit terhadap penanda gangguan ginjal pada penyakit systemic lupus erythematosus di RSUP dr. Wahidin Sudirohusodo tahun 2017-2018

Evi Andriyani Lauddin , Asvin Nurulita, Darwati Muhadi

Evi Andriyani Lauddin
Program Studi Pendidikan Dokter Spesialis, Ilmu Patologi Klinik, Fakultas Kedokteran Universitas Hasanuddin/RSUP Dr. Wahidin Sudirohusodo, Makassar, Indonesia. Email: evi_andriyani@yahoo.co.id

Asvin Nurulita
Departemen Ilmu Patologi Klinik, Fakultas Kedokteran Universitas Hasanuddin/ RSUP Dr. Wahidin Sudirohusodo, Makassar, Indonesia

Darwati Muhadi
Departemen Ilmu Patologi Klinik, Fakultas Kedokteran Universitas Hasanuddin/ RSUP Dr. Wahidin Sudirohusodo, Makassar, Indonesia
Online First: April 01, 2019 | Cite this Article
Lauddin, E., Nurulita, A., Muhadi, D. 2019. Analisis rasio netrofil limfosit dan rasio platelet limfosit terhadap penanda gangguan ginjal pada penyakit systemic lupus erythematosus di RSUP dr. Wahidin Sudirohusodo tahun 2017-2018. Intisari Sains Medis 10(1). DOI:10.15562/ism.v10i1.362


Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that causes damage to several organ systems including the kidneys. The neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) continue to be developed as a marker of SLE disease activity. This study aimed to assess NLR and PLR for markers of kidney disorders in SLE.

Method: A retrospective study evaluated NLR and PLR with routine urine results including proteinuria, hematuria, and casts from 40 subjects of SLE patients at Dr.Wahidin Sudirohusodo Hospital Makassar from July 2017 - July 2018. Descriptive statistical analysis, frequency distribution and Mann-Whitney statistical test.

Results: NLR values were significantly higher in positive hematuria than negative hematuria, which was 7.44 compared to 3.80 (p <0.05).

Conclusion: A significant relationship between increased NLR values and hematuria can be used as a marker of early occurrence of lupus nephritis even though no manifestations or signs of other kidney disorders are found.

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