Research Article

DOI: 10.15562/ism.v10i1.362

Analisis rasio netrofil limfosit dan rasio platelet limfosit terhadap penanda gangguan ginjal pada penyakit systemic lupus erythematosus di RSUP dr. Wahidin Sudirohusodo tahun 2017-2018

Evi Andriyani Lauddin , Asvin Nurulita, Darwati Muhadi

Evi Andriyani Lauddin
Program Studi Pendidikan Dokter Spesialis, Ilmu Patologi Klinik, Fakultas Kedokteran Universitas Hasanuddin/RSUP Dr. Wahidin Sudirohusodo, Makassar, Indonesia. Email: evi_andriyani@yahoo.co.id

Asvin Nurulita
Departemen Ilmu Patologi Klinik, Fakultas Kedokteran Universitas Hasanuddin/ RSUP Dr. Wahidin Sudirohusodo, Makassar, Indonesia

Darwati Muhadi
Departemen Ilmu Patologi Klinik, Fakultas Kedokteran Universitas Hasanuddin/ RSUP Dr. Wahidin Sudirohusodo, Makassar, Indonesia
Online First: April 01, 2019 | Cite this Article
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Lauddin, E., Nurulita, A., Muhadi, D. 2019. Analisis rasio netrofil limfosit dan rasio platelet limfosit terhadap penanda gangguan ginjal pada penyakit systemic lupus erythematosus di RSUP dr. Wahidin Sudirohusodo tahun 2017-2018. Intisari Sains Medis 10(1). DOI:10.15562/ism.v10i1.362


Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that causes damage to several organ systems including the kidneys. The neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) continue to be developed as a marker of SLE disease activity. This study aimed to assess NLR and PLR for markers of kidney disorders in SLE.

Method: A retrospective study evaluated NLR and PLR with routine urine results including proteinuria, hematuria, and casts from 40 subjects of SLE patients at Dr.Wahidin Sudirohusodo Hospital Makassar from July 2017 - July 2018. Descriptive statistical analysis, frequency distribution and Mann-Whitney statistical test.

Results: NLR values were significantly higher in positive hematuria than negative hematuria, which was 7.44 compared to 3.80 (p <0.05).

Conclusion: A significant relationship between increased NLR values and hematuria can be used as a marker of early occurrence of lupus nephritis even though no manifestations or signs of other kidney disorders are found.

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