Research Article

Analisis hubungan Rasio Trombosit Limfosit (RTL) dengan derajat keparahan stenosis pada pasien Coronary Artery Disease (CAD)

Zahra Inayah Kasim , Sulina Yanti Wibawa, Darmawaty E. Rauf

Zahra Inayah Kasim
Program Pendidikan Dokter Spesialis Ilmu Patologi Klinik FK UNHAS / RSUP dr. Wahidin Sudirohusodo, Makassar, Indonesia. Email: inayahzara@yahoo.com

Sulina Yanti Wibawa
Departemen Ilmu Patologi Klinik FK UNHAS / RS Stella Maris Makassar, Indonesia

Darmawaty E. Rauf
Departemen Ilmu Patologi Klinik FK UNHAS / RS Islam Faisal Makassar, Indonesia
Online First: August 01, 2019 | Cite this Article
Kasim, Z., Wibawa, S., Rauf, D. 2019. Analisis hubungan Rasio Trombosit Limfosit (RTL) dengan derajat keparahan stenosis pada pasien Coronary Artery Disease (CAD). Intisari Sains Medis 10(2). DOI:10.15562/ism.v10i2.360


Background: Atherosclerosis in CAD is marked by formation of plaque inside the arterial lumen. Platelet plays a role on formation and development of atherosclerosis. Adhesion of platelets to the endothelial cells followed by releasing platelet granules caused inflammation of endothel. Lymphocytes also play a role in atherosclerosis and atherotrombosis. T lymphocyte was the first to be recruited inside atheromas and gathered along inside an unstable plaque. The severity of stenosis can be calculated using Gensini score. The Aim of this study is to analyze the correlation between PLR and degree of stenosis in CAD.

Methods. This study is a retrospective study by collected 110 patients with CAD that had undergone coronary Angiography. Platelets and lymphocyte count were measured by automatic haematologycal analyzer. PLR was measured by dividing trombocyte count with absolute lymphocyte. Angiography findings were calculated using Gensini score and later devided into 3 groups according to degree of severity.

Results. 110 patients retrospectively assesed, 80% were male and 20% female. The most age found was 50-59 years (35.5%). Using Anova test there is a significant differences on  PLR between 3 groups of lesions (p<0.05). Continued with Posthoc test, the only significant finding was PLR between moderate and severe lesion. By Spearman’s Correlation test, there is a positif colleration between PLR and severity of stenosis (p<0.048), with R value 0.189 (3.6%).

Conclusions. There was a poor correlation between PLR and degree of stenosis severity in CAD. A prospective study needed to assess PLR as predictor of mortality and morbidity in CAD.

References

Kemenkes RI. Penyakit Jantung Penyebab Kematian Tertinggi. 2017. Dapat diakses pada www.depkes.go.id.

Indonesia PDSK. Pedoman Tata Laksana Sindrom Koroner Akut. Jakarta; 2015.

Thanassoulis G, Ashar M. Atherosclerosis in Cardiovascular Disorders. MSD Manual Professional Edition. 2016; 1-18

Ambrose J, Singh M. Pathophysiology of Coronary Artery Disease leading to Acute Coronary Syndromes. F1000Prime Rep. 2015;7:08

Davi G, Patrono C. Platelet Avtivation and Atherothrombosis. N Engl J Med. 2007; 357: 2482-2494

Akboga MK, Canpolat U, Yayla C, Ozcan F, Ozeke O, Topaloglu S, Aras D.. Association of platelet to lymphocyte ratio with inflammation and severity of coronary atherosclerosis in patients with stable coronary artery disease. Angiology. 2016; 67(1):89-95

Oylumlu M, Yıldız A, Oylumlu M, Yüksel M, Polat N, Bilik MZ, et al. Platelet to lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome. Anatol J Cardiol. 2015;15(4):277-83

Gensini GG. Coronary Arteriography. In : Heart Disease, Braunwald E. WB Saunders. 1980:352-3

Chen ZW, Chen YH, Qian JY, Ma JY, Ge JB. Validation of a Novel Clinical Prediction Score for Severe CAD before Elective Coronary Angiography. PLoS One. 2014; 9(4):e94493

Zhou D, Wang G, Fan Y, Wan Z, Liu X. Platelet to lymphocyte ratio is associated with the severity of CAD and clinical outcomes of PCI in Chinese Han population. Exp Ther Med. 2017; 13(2):731–738

de Boer OJ, Becker AE, van der Wal AC. T lymphocytes in atherogenesis-functional aspects and antigenic repertoire. Cardiovasc Res. 2003; 60(1):78-86.

Poppy LM. Perkembangan Konsep Patogenesis Aterosklerosis. Laboratorium PA FK Unsrat Manado. Jurnal Biomedik. 2009; (1)12-22.


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