Research Article

The correlation between serum magnesium level and blood pressure in patient with chronic kidney disease

Maulida Devi Yanti , Lisyani Budipradigdo Suromo

Maulida Devi Yanti
Clinical Pathology Resident of Faculty of Medicine of Diponegoro University, Semarang, Indonesia. Email:

Lisyani Budipradigdo Suromo
Clinical Pathology Department Staff of Faculty of Medicine of Diponegoro University, Semarang, Indonesia
Online First: April 01, 2019 | Cite this Article
Yanti, M., Suromo, L. 2019. The correlation between serum magnesium level and blood pressure in patient with chronic kidney disease. Intisari Sains Medis 10(1). DOI:10.15562/ism.v10i1.359

Background: Increased blood pressure is one of the complications from hemodialysis in Chronic Kidney Disease (CKD) patients. Magnesium is an electrolyte which is a calcium antagonist in regulating blood pressure. This study aims to prove the correlation of serum magnesium level with blood pressure in CKD patients

Methods: A cross-sectional study was conducted on 30 CKD patients in Dr. Kariadi Hospital, Semarang during September–October 2018. The serum magnesium level was measured with spectrophotometry method, blood pressure with a sphygmomanometer. Statistical analysis used Pearson and Spearman correlation test.

Result: There is a significant correlation between serum magnesium level and systolic blood pressure with p< 0,001 and r=-0,737 and correlation between serum magnesium level and diastolic blood pressure with p=0,011 and r=-0,457

Conclusion: There is a strong negative correlation of serum magnesium level with systolic blood pressure and moderate negative correlation of serum magnesium level with diastolic blood pressure in this study. Further studies are needed to analyze the influential factors of blood pressure.


KDIGO. Clinical practice guideline for the evaluation and management of chronic kidney disease.2012, available from;

Henry Ford Health System. Chronic kidney disease: Clinical practice recommendations for primary care physicians and healthcare providers.

Edition 6.0;2011, available from ;

Pusat Data dan Informasi Kementerian Kesehatan RI, Infodatin .2017:1-2

Perkumpulan Nefrologi Indonesia (PERNEFRI), 4th Report of Indonesian Renal registry. 2011:13

National kidney foundation, annual report. 2005. Available from;

Biolab Medical Unit Nutritional and Environmental Medicine.

Magnesium. 2013. Available from:

Toka HR, Al-Romaih K et al.: Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J

Am Soc Nephrol.2012;23:1879–1890

Mohammad Hassan Entezari. The effect of supplementary calcium on blood pressure in healthy adult women aged 18-30 years in Tehran, Iran. J Educ Health Promot. 2015;4:67

Humphrey S, Kirby R, Rudloff E. Magnesium physiology and clinical

Therapy in veterinary critical care. J Vet Emerg Crit Care.2015; 25(2):210-25

Manal Mohamed Zaher et al. Serum Magnesium Level and Vascular Stiffness in Children with Chronic Kidney Disease on Regular Hemodialysis. Saudi J Kidney Dis Transpl.2016;27(2):233-240

Muhammad Rafique Ansari et al. Correlation of Serum Magnesium with Dyslipidemia in Patients on Maintenance Hemodialysis. Saudi J Kidney Dis Transpl 2012;23(1):21-25

Salamanja et al. Hubungan lama menjalani hemodialisis dengan stress pada pasien penyakit ginjal kronik di RSUD Prof. Dr. H. Aloe Saboe Kota Gorontalo.2015;(3): 2-5

David A. Mccarron, Cynthia D. Morris, Richard Bukoski. The calcium paradox of essential hypertension. Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland, Oregon, USA.. AJM. 2007;82(1 Supplement 2):27–33

Magnesium liquicolor. Photometric colorimetric test for Magnesium with Lipid Clearing Factor. 2010

Zhang Xi, et al. Effects of Magnesium Supplementation on Blood Pressure ; A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68:20-30

Houston Mark, The Role of Magnesium in Hypertension and Cardiovascular Disease, J Clin Hypertens (Greenwich). 2011;13:843–47

Shina Lee et al. The Relationship between Magnesium and Endothelial Function in End-Stage Renal Disease Patients on Hemodialysis; Yonsei Med J.2015;57(6):1446-1453

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