Research Article

Hubungan antara Chronic Kidney Disease (CKD) dengan hipotiroid di RSUP Dr. Kariadi Semarang, Indonesia

I Gede Ardy Surya Dharmanta , Indranila Kustarini Samsuria

I Gede Ardy Surya Dharmanta
PPDS-1 Patologi Klinik Fakultas Kedokteran Universitas Diponegoro, Semarang. Email: ardysurya@gmail.com

Indranila Kustarini Samsuria
Bagian Patologi Klinik Fakultas Kedokteran Universitas Diponegoro, Semarang
Online First: April 01, 2019 | Cite this Article
Dharmanta, I., Samsuria, I. 2019. Hubungan antara Chronic Kidney Disease (CKD) dengan hipotiroid di RSUP Dr. Kariadi Semarang, Indonesia. Intisari Sains Medis 10(1). DOI:10.15562/ism.v10i1.353


Background: Thyroid hormone in many previous studies have been linked to chronic kidney disease (CKD). There are several interactions between renal dysfunction and thyroid hormones that influence each other. The aim of this study was to see the effect of CKD on the thyroid.

Methods: Cross sectional studies on subject data taken retrospectively by looking at medical records on a single center Dr. Kariadi Semarang Hospital during the period 1 June 2017 – 1 June 2018 to then observe the correlation effect of CKD on thyroid hormones by comparing serum urea and creatinine with T3, T4 and

TSH.

Results: There was a significant correlation of CKD on T3 and TSH levels with ureum (p = 0.020 and p = 0,0,25), and there was a significantly weak correltaion with creatinin (p = 0,081), but there was no significant correlation in T4 (p=0,102; p = 0,108).

Conclusion: The results of this study can be concluded that there is a significant correlation between Chronic Kidney Disease (CKD and hypothyroidism, especially the correltation effect of T3 with ureum and creatinine, and TSH with ureum.

References

Aryee NA, Tagoe EA, Anomah V, Arko-Boham B, Adjei DN. Thyroid hormone status in Ghanaian patients with chronic kidney disease. Pan Afr Med. J . 2018; 29 (1):137-143.

Melonie Heron. [Internet] “Centers for Disease Control and Prevention,” Leading Causes of Death, 2018 July 26, [updated 2018 feb 11; cited 2018 Sept 19] from : http://www.cdc.gov/nchs/fastats/lcod.htm.

Riskesdas.Badan Penelitian dan Pengembangan Kesehatan Kementrian RI. Riset kesehatan dasar. Jakarta : 2013:83-97.

Klein I and Ojamaa K: Thyroid hormone and the cardiovascular system. N Engl J Med, 2001; 344(7): 501-509

Villabona C, Sahun M, Gomez N, Gomez JM, Soler J, Roca M et al. Blood volumes and renal function in overt and subclinical primary hypothyroidism. Am J Med Sci, 1999; 318 (4): 277-280.

Khaleeli AA, Griffith DG and Edwards RHT. The clinical presentation of hypothyroid myopathy and its relationship to abnormalities in structure and function of skeletal muscle. Clin Endocrinol, 1983; 19(3): 365-376

Peixoto MEJ, Bittencourt MS, Pereira AC, Goulart AC, Santos IS, Lotufo PA et al. Subclinical hypothyroidism is associated with higher carotid intima-media thickness in cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Nutr Metab Cardiovasc Dis. 2016; 26(10): 915-921.

Zhou Y, Zhao L, Wang T, Hong J, Zhang J, Xu B et al. Free triiodothyronine concentrations are inversely associated with elevated carotid intima-media thickness in middle-aged and elderly chinese population. J Atheroscler Thromb, 2016; 23(2): 216-224.

Shimizu M, Furusyo N, Mitsumoto F, Takayama K, Ura K, Hiramine S et al. Sub clinical carotid atherosclerosis and triglycerides predict the incidence of chronic kidney disease in the Japanese general population: Results from the Kyushu and Okinawa Population Study (KOPS). Atherosclerosis, 2015; 238(2): 207- 212

Nambi V, Chambless L, Folsom AR, He M, Hu Y, Mosley T et al. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk in the atherosclerosis risk in communities (ARIC) study. J Am Coll Cardiol, 2010; 55(15): 1600-1607.

Basu G and Mohapatra A. Interactions between thyroid disorders and kidney disease. Indian J Endocr Metab 2012;16(2): 204–213.

Singh PA, Bobby Z, Selvaraj N, Vinayagamoorthi R. An evaluation of thyroid hormone status and oxidative stress in undialyzed chronic renal failure patients. Indian J Physiol Pharmacol. 2006;50(3):279–284.

Kannan A, Sriramakrishnan V, Kannan B, Anandan H. Thyroid function abnormalities in patients with chronic kidney disease - A prospective study. Int J of Scientific study 2017; 5(4):68-72.

Lim VS, Fang VS, Katz AI, and Refetoff S. Thyroid dysfunction in chronic renal failure. A study of the pituitary-thyroid axis and peripheral turnover kinetics of thyroxine and triiodothyronine. J Clin Invest 1977;60(3): 522–534.

Wiederkehr MR, Kalogiros J and Krapf R. Correction of metabolic acidosis improves thyroid and growth hormone axes in haemodialysis patients. Nephrol Dial Transplant. 2004;19(5):1190–1197.

Zoccali C, Tripepi G, Cutrupi S, Pizzini P and Mallamaci F. Low triiodothyronine: A new facet of inflammation in end-stage renal disease. J Am Soc Nephrol. 2005;16(9):2789–2795.


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