Skip to main content Skip to main navigation menu Skip to site footer

Hubungan jenis packed red cell (PRC) yang ditransfusikan dengan reaksi transfusi febrile non haemolytic transfusion reaction (FNHTR)


Background: One of the components of blood cells are often used for transfusions is Packed Red Cell (PRC). Blood components transfusion may continues with rapid or delayed transfusion ractions. The most transfusion reactions  was fever (55%) or febrile non haemolytic transfusion reaction (FNHTRs). The cause of these events is associated with allogenic leucocytes (the ability to differentiate self cells and non-self cells based on the human leukocyte antigen (HLA) on the cell surface) and release of proinflammatory cytokines such as IL-1, IL-6, IL-8, TNFα, Cell-free DNA (cfDNA), histone and the duration of blood storage.

Methods: Cross-sectional study on 41.177 patients who received a PRC transfusion with the FNHTR transfusion reaction in Hospital Blood Bank Dr. Kariadi Semarang, during  January 2017 to July 2018. Pearson Chi Square test for expected frequency more than 5. The Kolmogorov smirnov and Shapiro-wilk test were used to evaluate normality of the data. Mann-Whitney test to analyze the difference, p < 0,05 was considered as significant.

Results: The incidence of FNHTR was lower in patients who received leukodepleted PRC (11 patients) than non leukodepleted PRC (124 patients). There were differences in body temperature in the incidence of FNHTR between the two groups 38.10 C (38-39) VS 38.40 C (38 – 39.2) with p = 0,046.

Conclusions:There were relationship between the incidence of FNHTR with the transfusion with leukodepleted PRC and non leukodepleted PRC.


  1. Bermawi H. Transfusi Darah dan Komponen Darah. Buku Ajar Neonatologi Ikatan Dokter Indonesia.
  2. Joseph D, Yvonne Rizk: Clinical transfusion Medicine. Landes Bioscience 1999.
  3. Palang Merah Indonesia. Pelayanan Transfusi Darah, 2002.
  4. Peraturan Menteri Kesehatan Nomor 91 Tahun 2015 Tentang Standar Pelayanan Transfusi Darah.
  5. A Pustika, B Nitish. Transfusi Rasional pada Anak Pustika Amalia Wahidiyat. 2015.
  6. Shih AW, Bhagirath VC, Heddle NM, Acker JP, Liu Y, Eikelboom JW, Liaw PC. Quantification of Cell-Free DNA in Red Blood Cell Units in Different Whole Blood Processing Methods. J Blood Transfus. 2016;2016:9316385
  7. Raat NJ, Ince C. Oxygenating the microcirculation: the perspective from blood transfusion and blood storage. Vox Sang 2007; 93(1):12-18.
  8. Raat NJ, Verhoeven AJ, Mik EG, Gouwerok CW, Verhaar R, Goedhart PT, de Korte D, Ince C: The effect of storage time of human
  9. red cells on intestinal microcirculatory oxygenation in a rat
  10. isovolemic exchange model. Crit Care Med. 2005; 33(1):39-45.
  11. Rajesh K, Harsh S, Amarjit K. Effects of Prestorage Leukoreduction on the Rate of Febrile Nonhemolytic Transfusion Reactions to Red Blood Cells In A Tertiary Care Hospital. Ann Med Health Sci Res. 2015; 5(3):185-8
  12. Mazzei CA, Popovsky MA, Kopko PM. Noninfectious
  13. complications of blood transfusion. In: Roback JD, Combs MR,
  14. Grossman BJ, et al., eds. Technical Manual, 16th Ed. Bethesda,
  15. MD: American Association of Blood Banks; 2008:715-749.
  16. M. Menis, R. A. Forshee, S. A. Anderson, S. McKean, R. Gondalia, R. Warnock, C. Johnson, P. D. Mintz, et al. Febrile non-haemolytic transfusion reaction occurrence and potential risk factors among the U.S elderly transfused in the inpatient setting, as recorded in Medicare databases during 2011–2012. Vox Sang. 2015; 108(3):251-61.
  17. Solheim BG, Flesland O, Seghatchian J, Brosstad F. Clinical implications of red blood cell and platelet storage lesions: an overview. Transfus Apher Sci 2004; 31(3):185-189.
  18. Raghavan M, Marik PE: Anemia, allogenic blood transfusion, and
  19. immunomodulation in the critically ill. Chest. 2005; 127(1):295-307.
  20. Nielsen HJ, Reimert CM, Pedersen AN, Brünner N, Edvardsen L,
  21. Dybkjaer E, Kehlet H, Skov PS. Time-dependent, spontaneous
  22. release of white cell- and platelet-derived bioactive substances from stored human blood. Transfusion. 1996; 36(11-12):960-965.
  23. Domen RE, Hoeltge GA. Allergic transfusion reactions: An
  24. evaluation of 273 consecutive reactions. Arch Pathol Lab Med. 2003;127(3):316-20.
  25. Popovsky MA, Robillard P, Schipperus M, Stainsby D, Tissot JD, Wiersum J, ISBT Working Party on Haemovigilance. Proposed standard definitions for surveilance of non infectious adverse transfusion reactions. 2011.
  26. Kopko PM, Holland PV. Mechanisms of severe transfusion
  27. reactions. Transfus Clin Biol. 2001; 8:278-81.
  28. Bolton-Maggs PH, Cohen H. Serious Hazards of Transfusion (SHOT) haemovigilance and progress is improving transfusion safety. Br J Haematol 2013; 163:303-14.
  29. Mirski MA, Lele AV, Fitzsimmons L, Toung TJ. Diagnosis and treatment of vascular air embolism. Anesthesiology 2007; 106:164-77.

How to Cite

Kamilah, D., & Widyaningrum, D. (2019). Hubungan jenis packed red cell (PRC) yang ditransfusikan dengan reaksi transfusi febrile non haemolytic transfusion reaction (FNHTR). Intisari Sains Medis, 10(1).




Search Panel