Research Article

Korelasi kadar leptin serum terhadap derajat penyakit dermatitis atopik

Gde Ngurah Arya Ariwangsa , Made Wardhana, Luh Made Mas Rusyati

Gde Ngurah Arya Ariwangsa
Departemen Kulit dan Kelamin RSUP Sanglah Fakultas Kedokteran Universitas Udayana. Email: aryaariwangsa@yahoo.co.id

Made Wardhana
Departemen Kulit dan Kelamin RSUP Sanglah Fakultas Kedokteran Universitas Udayana

Luh Made Mas Rusyati
Departemen Kulit dan Kelamin RSUP Sanglah Fakultas Kedokteran Universitas Udayana
Online First: April 01, 2019 | Cite this Article
Ariwangsa, G., Wardhana, M., Rusyati, L. 2019. Korelasi kadar leptin serum terhadap derajat penyakit dermatitis atopik. Intisari Sains Medis 10(1). DOI:10.15562/ism.v10i1.334


Background: Atopic dermatitis (AD) is a chronic and residual skin inflammatory disease in which the symptoms include intense itching, chronic exacerbations and remissions, with multifactorial etiologies. The role of leptin in DA is closely related to polarization of T cells towards Th1 cells resulting in the release of pro-inflammatory cytokines.

Methods: A cross-sectional study was conducted among 30 atopic dermatitis patients at Sanglah General Hospital in the period of July-August 2018. The leptin examination was carried out using the ELISA method. Data analysis were performed using SPSS version 25.0 software with the Spearman correlation test to determine the relationship between levels of serum leptin and the severity of atopic dermatitis based on SCORAD.

Results: Most of the respondents were females (66.7%) with an average leptin level was 25.75 + 18.21 pg/dL. The results showed a significant negative correlation between the level of serum leptin and the severity of DA (SCORAD) (r: -0.127; p: 0.043). However, there was a significant positive correlation between pH of the skin and SCORAD (r: 0.810 and p: <0.001).

Conclusions: There is a negative correlation between level of serum leptin and SCORAD but it has a strong positive correlation between the pH of the skin and SCORAD.

References

Bieber T, Bussmann C. Atopic Dermatitis. In: Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology. 3th Ed. Elsevier Saunders. 2012: 203-218.

Leung DY. Atopic Dermatitis: New Insights and Opportunities for Therapeutic Intervention. J Allergy Clin Immunol. 2000; 105(5):860-76.

Leung DY, Lawrence FE, Boguniewics M. Atopic Dermatitis (Atopic Eczema). In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s Dermatology in General Medicine. 8th ed. New York: McGraw Hill. 2012: 165-82.

Rubel D, Thirumoorthy T, Soebaryo RW, Weng SCK, Gabriel TM, Villafuerte LL et al. Consensus Guidelines for The Management of Atopic Dermatitis: An Asia-Pacific Perspective. J Dermatol, 2013; 40(3):160-71.

Wardhana M, Suryawati N, Ariana. The effect of psychological stress on C-reactive protein and peripheral blood cells count in chronic idiopathic urticaria. Bali Medical Journal. 2017; 6(1):198-203

Wauman J, Zabeau L, Tavernier J. The Leptin Receptors Complex: Heavier than Expected. Front Endocrinol. 2017; 8(30):1-20.

Mantzoros CS, Magkos F, Brinkoetter N et al. Leptin in Human Physiology and Pathophysiology. Am J Physiol Endocrinol Metab. 2011; 301(4):567-84.

Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 2010;152(2):93-100

Liu W, Zeng Q, Zhou L, Luo R, Dong H. Association of Leptin with Disease Severity and Inflammation Indicators in Chinese Obese Childrn with Allergic Rhinitis. Peidatric Allergy Immunol. 2018; 29(2):186-193.

Mohamed SA, Alsayad T, El-Askary A, Alwata HA. Serum Leptin Level among School Children with Atopic Dermatitis. Neonatal Pediatric Med. 2017; 3(2);1-6.

Seo S, Won SY, Cho Y, Park SH, Choung JT, Yoo Y. Leptin and Atopic Dermatitis in Korean Elementary School Children. Iran J Allergy Asthma Immunol. 2016; 15(2):138-144.

Vina GA. Kadar Serum Leptin Yang Tinggi Merupakan Faktor Risiko Terjadinya Dermatitis Atopik” [Tesis]. Universitas Udayana. 2018

Maymí MA, Somolinos AL, Nazario CM, Sánchez JL. The prevalence of atopic dermatitis in Puerto Rican schoolchildren. P R Health Sci J. 2007; 26(2):127-33.

Balato N, Nino M, Patruno C, Matarese G, Ayala F. "Eczemas" and leptin. Dermatitis. 2011; 22(6):320-3.

Seo SC, Yoon WS, Cho Y et al. Leptin and Atopic Dermatitis in Korean Elementary School Children. Iran J Allergy Asthma Immunol. 2016; 15(2):138-144

Nagel G, Koenig W, Rapp K, Wabitsch M, Zoellner I, Weiland SK. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Pediatr Allergy Immunol. 2009; 20(1):81-8.

Knor T, Meholjić-Fetahović A, Mehmedagić A. Stratum corneum hydration and skin surface pH in patients with atopic dermatitis. Acta Dermatovenerol Croat. 2011; 19(4):242-7.

Rippke F, Schreiner V, Doering T, Maibach HI. Stratum corneum pH in atopic dermatitis: impact on skin barrier function and colonization with Staphylococcus Aureus. Am J Clin Dermatol. 2004; 5(4):217-23.

von Gunten S, Marsland BJ, von Garnier C, Simon D. Update in clinical allergy and immunology. Allergy. 2012; 67(12):1491-500

Kubo A, Nagao K, Amagai M. Epidermal Barrier Dysfunction and Cutaneus in Atopic Dermatitis. J Clin Invest. 2012; 113(5):651-57.

Elias PM, Hachem JP, Crumrine D, Fluhr J, Brown BE, Feingold KR. pH Directly Regulates Epidermal Permeability Barrier Homeostasis, and Stratum Corneum Integrity/Cohesion. J Invest Dermatol. 2003; 125: 510-20.

Boguniewicz M, Leung DYM. Atopic Dermatitis: A Disease of Altered Skin Barrier and Immune Dysregulation. Immunol Rev. 2011; 242(1):233–246.


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