Skip to main content Skip to main navigation menu Skip to site footer

The characteristic of neonatal hyperbilirubinemia before and after phototherapy at Sanglah Hospital, Denpasar, Bali in 2017

Abstract

Background: Hyperbilirubinemia is the most clinical problem in newborn babies.  Hyperbilirubinemia occurs 60% in aterm babies and 80% in premature babies. This study aims to know the incidence of hyperbilirubinemia, characteristics of hyperbilirubinemia and effect of phototherapies to bilirubin levels.

Methods: A cross-sectional retrospective study was conducted using medical records among 94 neonates with hyperbilirubinemia who treated with phototherapies at Sanglah hospital during 2017. Data regarding gender, gestational weeks, type of delivery, size for gestational age, the onset of hyperbilirubinemia, etiology, birth weight, maternal gravid status, and bilirubin levels were collected and analyzed using SPSS version 20 software descriptively.

Results: From 94 neonatal hyperbilirubinemia that meet the inclusion criteria, 51 (54.3%)  males and 43 (45.7%) females based on gender. Mean gestational ages were 36.35±2.921 weeks. The major etiology of neonatal hyperbilirubinemia were breastfeeding jaundice 33 (25.8%), Prematurity 23 (18.7%), ABO incompatibility 13 (10.6%), Breast milk jaundice 11 (8.9%), gastrointestinal malformation 6 (4.9%), G6PD deficiency 5 (4.1%), and sepsis 3 (2.4%). The mean total bilirubin prior to phototherapy was 15.6±4.11 mg/dL whereas the indirect bilirubin was 14.56± 3.55 mg/dL. The duration of phototherapy in this study was 2.8±0.65 days.

Conclusions: The incidence of neonatal hyperbilirubinemia during 2017 at Sanglah Hospital were predominantly caused by breastfeeding jaundice, prematurity, and ABO incompatibility. There were decreased bilirubin levels following phototherapies.

References

  1. Mukhopadhyay S, Puopolo KM. Neonatal early-onset sepsis: epidemiology and risk assessment. NeoReviews. 2015; 16(4):221-8.
  2. Akgül S, Korkmaz A, Yiğit S, Yurdakök M. Neonatal hyperbilirubinemia due to ABO incompability: does blood group matter? Turk J Pediatr. 2013; 55(5):506-9
  3. Putri RA, Mexitalia M, Rini AE, Sulistyowati E. Faktor risiko hyperbilirubinemia pada neonatus. Med Hosp. 2014; 2(2):105-109
  4. Wibowo S. Perbandingan Kadar Bilirubin Neonatus Dengan dan Tanpa Defisiensi Glucose-6 Phosphate Dehidrogenase, Infeksi Dan Tidak Infeksi. Universitas Diponegoro. 2017. [Tesis]. Tersedia pada http://eprints.undip.ac.id/18714/1/Satrio_Wibowo2.pdf [ Diakses pada 5 May 2018 ]
  5. Sarici SU, Serdar MA, Korkmaz A, Erdem G, Oran O, Tekinalp G, Yurdakök M, Yigit S. Incidence, course, and prediction of hyperbilirubinemia in near-term and term newborns. Pediatrics. 2004; 113(4):775-780
  6. Yahya N, Yuniati T, Lubis L. Characteristics of neonatal hyperbilirubinemia at west java’s top referral hospital, Indonesia. AMJ. 2017; 4(2):167-172.
  7. Bhutani VK, Wong RJ, Stevenson DK. Hyperbilirubinemia in preterm neonates. Clin Perinatol. 2016; 43(2):201-218
  8. Bai JH, Mathew A. Risk factor for neonates with hyperbilirubinemia. Biomed J Sci & Tech Res. 2018; 2(1):1-2
  9. Butler-O'Hara M, Reininger A, Wang H, Amin SB, Rodgers NJ, D'Angio CT.. A randomized controlled trial of glycerin suppositories during phototherapy in premature neonates. J Obstet Gynecol Neonatal Nurs. 2017; 46(2):220-228.
  10. Fujiwara R, Maruo Y, Chen S, Tukey RH. Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol. 2015; 289(1):124-32.
  11. Gundur NM, Kumar P, Sundaram V, Thapa BR, Narang A. Natural history and predictive risk factors of prolonged unconjugated jaundice in the newborn. Pediatr Int. 2010; 52(5):769-72
  12. Zhu YP, Wang J, Li MX. Causes and management of hyperbilirubinemia in full-term newborns. Int J Clin Exp Med. 2016; 9(6):12060-12066.
  13. Sukadi A, Usman A, Efendi SH. Ikterus Neonatorum. Perinatologi. Bagian/SMF Ilmu Kesehatan Anak FKUP/RSHS. Bandung. 2002: 64-84.
  14. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia.. Management of hyperbilirubinemia in the newborn infant 35 weeks of gestation, Clinical Practice Guideline, Subcommittee on Hyperbilirubinemia. Pediatrics 2004; 114(1):297-316.
  15. Amato M, Huppi P, Markus D, Assessment of neonatal jaundice in low birth weight infants comparing transcutaneous, capillary and arterial bilirubin levels. Eur J Pediatr. 1990; 150(1):59-61
  16. Cloherty JP, Eichenwald EC, Stark AR. Neonatal hyperbilirubinemia in Manual of Neonatal Care. 5th edition. Philadelphia: Lippincolt Williams & Wilkins. 2004: 185-221.
  17. Dubal, G, Joshi, V. Neonatal factors affecting Neonatal Jaundice in Saurashtra Region of Gujerat. 5th Edition. Jamnagar. 2002; 77(2): 145-150.
  18. Maharoof MK, Khan SA, Saldanha PR, Mohamed R. Comparison of light emitting diode and compact fluorescent lamp phototherapy in treatment of neonatal hyperbilirubinemia. IJPed. 2017; 4(2):341-345

How to Cite

Sandhi Parwata, W. S., Putra, P. J., Kardana, M., Artana, W. D., & Sukmawati, M. (2019). The characteristic of neonatal hyperbilirubinemia before and after phototherapy at Sanglah Hospital, Denpasar, Bali in 2017. Intisari Sains Medis, 10(2). https://doi.org/10.15562/ism.v10i2.312

HTML
299

Total
676

Share

Search Panel

Wayan Sulaksmana Sandhi Parwata
Google Scholar
Pubmed
ISM Journal


Putu Junara Putra
Google Scholar
Pubmed
ISM Journal


Made Kardana
Google Scholar
Pubmed
ISM Journal


Wayan Dharma Artana
Google Scholar
Pubmed
ISM Journal


Made Sukmawati
Google Scholar
Pubmed
ISM Journal