Research Article

Korelasi negatif kuat kadar prolaktin plasma yang rendah terhadap derajat keparahan melasma

Angela Sandi Tagaroi Rahasia , Anak Agung Gde Putra Wiraguna, Luh Made Mas Rusyati

Angela Sandi Tagaroi Rahasia
Departemen Kulit dan Kelamin, Fakultas Kedokteran Universitas Udayana, RSUP Sanglah, Bali, Indonesia. Email: angela.rahasia2188@gmail.com

Anak Agung Gde Putra Wiraguna
Departemen Kulit dan Kelamin, Fakultas Kedokteran Universitas Udayana, RSUP Sanglah, Bali, Indonesia

Luh Made Mas Rusyati
Departemen Kulit dan Kelamin, Fakultas Kedokteran Universitas Udayana, RSUP Sanglah, Bali, Indonesia
Online First: April 01, 2019 | Cite this Article
Rahasia, A., Wiraguna, A., Rusyati, L. 2019. Korelasi negatif kuat kadar prolaktin plasma yang rendah terhadap derajat keparahan melasma. Intisari Sains Medis 10(1). DOI:10.15562/ism.v10i1.309


Background: Melasma is a chronic cutaneous hypermelanosis in areas exposed to sunlight. Hormonal factors are known to influence melanogenesis processes such as prolactin as a neuroendocrine modulator in skin epithelial growth and immune system. This study aims to prove the inverse relationship between plasma prolactin levels and the severity of melasma.

Methods: A cross-sectional study was carried out on 59 patients in the skin and genital olyclinic at Sanglah Hospital in Denpasar involving 46 subjects of melasma and 13 subjects who were not melasma who met the inclusion and exclusion criteria. Plasma prolactin levels were assessed by the Chemiluminescent microparticle immunoassay (CMIA) method. Data analysis was performed using SPSS ver. 23 software with a P-value <0.05 was considered statistically significant.

Results: Plasma prolactin levels in patients with melasma were significantly lower than non-melasma patients (p <0.05). Patients with moderate and severe degrees of melasma had significantly lower plasma prolactin levels compared with mild degree of melasma (p <0.05). Low plasma prolactin levels can increase the likelihood of melasma by 4.79 times (PR 4.79; 95% CI = 0.94-24.27; p <0.05). Low plasma prolactin levels were significantly strong negative correlated with melasma severity (r = -0.820; p <0.05).

Conclusion: There is a strong negative correlation of low plasma prolactin levels with the severity of melasma in patients with skin disorders at Sanglah General Hospital

References

Bleehen SS, Anstey AV.Disorder of skin colour: pathogenesis of disorders of melanin pigmentation, melasma. In: Burns T, Breathnach S, Cox N, Griffiths C, editor. Rook’s textbook of dermatology. 7. Massachusetts: Blackwell; 2004; 39:13-14

Roberts WE. Melasma. In: Kelly AP, Taylor SC, editor. Dermatology for skin of colour. New York: McGraw-Hill. 2009; 332-6.

Febrianti T, Sudharmono A, Rata IGAK, Bernadette I. Epidemiologi Melasma di Poliklinik Departemen Ilmu Kesehatan Kulit dan Kelamin RS. Dr. Cipto mangunkusumo Jakarta Tahun. Perdoski. 2004. Tersedia pada: perdoski.org/index.php/public/information/mdvi-detail-content/86. [Diakses 17 Juni 2017]

Diven DG, Gwinup G, Newton RC. The thyroid. Dermatol Clin. 1989; 7:547- 558

Dogra A, Dua A, Singh P. Thyroid and skin. Indian Journal of Dermatology. 2006; 51(2): 96-9.

Mahmood K, Nadeem M, Aman S, Hameed A, Kazmi AH. Role of Estrogen, Progesterone, and Prolactin in the Etopathogenesis of Melasma in Females. Journal of Pakistan Association of Dermatologist. 2011; 21(4):241-247

Langan EA, Foitzik-Lau K, Goffin V, Ramot Y, Paus R. Prolactin: An Emerging Force along the Cutaneous-Endocrine Axis. Trends Endocrinol Metab. 2010; 21:569-77.

Gopichandani K, Arora P, Garga U, Bhardwaj M, Sharma N, Gautam RK. Hormonal profile of melasma in Indian females. Pigment Int. 2015; 2: 85-90.

Pérez M, Sánchez JL, Aguiló F. Endocrinologic profile of patients with idiopathic melasma. J Invest Dermatol. 1983; 81:543‑5.

Hassan I, Kaur I, Sialy R, Dash RJ. Hormonal milieu in the maintenance of melasma in fertile women. J Dermatol. 1998; 25:510‑2.

Bhattarai S, Pradhan K, Sharma S, Rajouria EA. Clinical patterns and epidemiological characteristics of melasma in a tertiary care hospital of Nepal. Pigmentary Disorder Society. 2017; 4(1):35-38

Tamega Ade A, Miot LD, Bonfietti C, Gige TC, Marques ME, Miot HA. Clinical patterns and epidemiological characteristic of facial melisma in Brazillian women. J Eur Acad Dermatol Venereol. 2013; 27(2):151-6

Djajapranata K. Profil Melasma pada Perempuan Usia 16-65 Tahun Menggunakan Lampu Wood di Rejuva Skin & Beauty Surabaya. Surabaya: Repositori Universitas Katolik Widya Mandala. 2016

Kaur S, Kaur J, Sharma S, Sharma M, Mahajan A, Singh A. A Clinico-dermatocospic study of 100 cases of melisma in a tertiary care hospital. Int J Res Dermatol. 2018; 4(1):41-45

Muller I, Rees DA. Melasma and Endocrine Disorders. Pigmentary Disorders. 2014; S1:001

Praharsini I, Suryawati N, Dewi H. Skor kualitas hidup dermatologi berkolerasi positif dengan melisma area and severity indez. Intisari Sains Medis. 2017; 8(2):189-192

Roelfsema F, Pijl H, Keenan DM, Veldhuis JD. Prolactin Secretion in Healthy Adults Determined by Gender, Age and Body Mass Index. Plos One. 2012; 7(2): 1-10.

Handel AC, Miot LDB, Miot HA. Melasma: a clinical and epidemiological review. An Bras Dermatol. 2014; 89(5): 771-82.

Martin M, Hamdullah A, Priya S. Unveiling factors behind melasma: an Observational Study. IAIM. 2017; 4(11):85-89

Sonthalia S, Sarkar R. Etiopathogenesis of Melasma. Pigmentary Disorders Society. 2015; 2(1):21-27

Videira IF, Magina S, Moura DFF. Mechanisms regulating melanogenesis. An Bras Dermand. 2013; 88(1): 76-83.

Tse TW, Hui E. Tranexamid Acid: an Important Adjuvant in the Treatment of Melasma. Journal of Cosmetic Dermatology. 2013; 12:57-66

Lee AY. An Update Review of melasma Pathogenesis. South Korea. Dermatologica Sinica. 2014; 32:233-39.

Laperee H, Boone B, Schepper SD et al. Hypomelanoses and Hypermelanoses. In: Fitzpatrick TB, Wolff K, editor. Dermatology in general medicine. New York: McGraw – Hill. 2008; (7):622-640

Bhattarai S, Pradhan K, Sharma S, Rajouria EA. Clinical patterns and epidemiological characteristics of melasma in a tertiary care hospital of Nepal. Pigment Int 2017;4:35-8

Mahmood K, Nadeem M, Aman S, Hameed A, Kazmi AH. Role of estrogen, progesterone, and prolactin in the etiopathogenesis of melasma in females. Journal of Pakistan Association of Dermatologists. 2011; 21(4):241-247.

Hassan I, Kaur I, Sialy R, Dash RJ. Hormonal milieu in the maintenance of melasma in fertile women. J Dermatol. 1998; 25(8):510-2.

Natale C, Dupperet E, Zhang J, Sadeghi R, Dahal A, Brien K et al. Sex Steroids regulate skin pigmentation through nonclassical membrane bound receptor. eLife. 2016; 1-15

Lee AY. Recent progress in melasma pathogenesis. Pigment Cell Melanoma Res 2015; 28:648-60


No Supplementary Material available for this article.
Article Views      : 80
PDF Downloads : 42