Research Article

Red meat intake as a suspicious factor of colorectal cancer at Sanglah General Hospital in 2017

Ganeshwary Nishal Ganasan , Made Agus Dwianthara Sueta, Made Suka Adnyana

Ganeshwary Nishal Ganasan
Medical Science Study Program, Medical Faculty, Universitas Udayana. Email: ganeshwarynishal@gmail.com

Made Agus Dwianthara Sueta
Department of Surgery, Medical Faculty, Universitas Udayana, Sanglah General Hospital Denpasar Bali

Made Suka Adnyana
Department of Surgery, Medical Faculty, Universitas Udayana, Sanglah General Hospital Denpasar Bali
Online First: June 17, 2019 | Cite this Article
Ganasan, G., Sueta, M., Adnyana, M. 2019. Red meat intake as a suspicious factor of colorectal cancer at Sanglah General Hospital in 2017. Intisari Sains Medis 10(2). DOI:10.15562/ism.v10i2.291


Background: Colon and rectal cancer (colorectal cancer) is cancer with high morbidity and mortality. Colorectal cancer is the second leading cause of death among men and women. This cancer is also the third most common malignant neoplasm in the world, and its incidence has increased in recent years. A high diet of red meat is one of the risk factors that can increase the likelihood of colorectal cancer.

Aim: The study aims to determine the relationship between red meat consumption on the incidence of colorectal cancer.

Method: This study is an unmatched paired case-control study conducted in Sanglah Hospital using patient medical record data from 2016 to 2017. The number of colorectal cancer group and control group samples are 52 people, each group. Samples were then interviewed on the red meat diet using the questionnaire guidelines. Data on the diagnosis of colorectal cancer was obtained through the patient's medical record at Digestive Surgery Polyclinic, Sanglah Hospital, Denpasar.

Result: About 76.9% of colorectal cancer patients consume a high intake of red meat. Patients with colorectal cancer have a history of higher red meat intake than patients without colorectal cancer (OR = 9.048; 95% CI 3.716-22.026; p<0.001).

Conclusion: Red meat intake is a significant factor in the incidence of colorectal cancer in Sanglah Hospital. Limiting the consumption of red meat is recommended to reduce the risk of colorectal cancer.

References

National Cancer Institute. Colorectal Cancer; 2015. [online] Available at: http://www.cancer.gov/types/colorectal. [Accessed on: 28 Juni 2017]

Al-Jashamy, K. Principle and practice of cancer prevention and control. Foster City: OMICS Group eBook; 2013. p.2.

Sudoyo, A., Hernowo, B., Krisnuhoni, E., Reksodiputro, A., dan Hardjodisastro, D. Colorectal cancer among young native Indonesians: A clinicopathological and molecular assessment on microsatelite instability. Med J Indones. 2010; 245.

Vitriana, GK., Maliawan, S., dan Siki, KK. Karakteristik histologis, stadium klinis, dan terapi kanker kolon pada pasien lanjut usia di RSUP Sanglah. J Med Udayana; 2014.

Aykan, N. Red meat and colorectal cancer. Rev Oncol. 2015; 9(1).

Aulawi, T. Hubungan konsumsi daging merah dan gaya hidup terhadap risiko kanker kolon. J Penelitian Sos Agama. 2013; 16(1).

Wada, K., Oba, S., Tsuji, M., dkk. Meat consumption and colorectal cancer risk in Japan: The Takayama study. Cancer Sci. 2017; 108(5): 1065-70.

Alexander, DD., Weed, DL., Miller, PE., Mohamed, MA. Red meat and colorectal cancer: a quantitative update on the state of the epidemiologic science. J Am Coll Nutr. 2015; 34: 521-43.

Chan, DSM., Lau, R., Aune, D., dkk. Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PloS One. 2011;6: e20456.

Samraj, AN., Pearce, OM., Laubli, H., dkk. A red mear-derived glycan promotes inflammation and cancer progression. Proc Natl Acad Sci USA. 2015;112: 524-47.

Bastide, NM., Chenni, F., Audebert, M., dkk. A central role for heme iron in colon carcinogenesis associated with red meat intake. Cancer Res. 2015; 75: 870-9.


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