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Peran Epigallocatechin-3-gallate (EGCG) dalam Menghambat Perkembangan Fibrosis Pleura, Ekspresi SCUBE3, dan Transforming Growth Factror-β (TGF-β) pada Pasien Empiema: sebuah tinjauan pustaka

  • Muhammad Riendra ,
  • Nur Indrawaty Lipoeto ,
  • Rauza Sukma Rita ,
  • Masrul Basyar ,

Abstract

Empyema in the lungs can cause pulmonary fibrosis which can cause restrictions in the movement of the lung parenchyma. Epigallocatechin-3-gallate (EGCG) is the most active polyphenolic compound in gambier leaves (Uncaria gambir Roxb), which is known to inhibit the occurrence of pulmonary fibrosis due to empyema. This literature review discusses the role of EGCG in inhibiting the development of pleural fibrosis in empyema patients.

EGCG prevents bleomycin-induced increase in ROS formation, reverses the decrease in antioxidant status, and increases Nrf2 activity. EGCG also reduces inflammatory markers such as NF-κB, TNFα, IL-1β, and MPO activity levels and reduces histological signs of inflammation and lung injury. EGCG lowers hydroxyproline and glycoconjugates, products of collagen metabolism, reduces matrix-degrading lysosomal hydrolases and improves ultrastructural changes in the lungs. EGCG also exerts antifibrotic activity by suppressing the expression of TGF-β and the SCUBE3 gene.

The EGCG compound inhibits the development of pulmonary fibrosis in empyema through antioxidant and antifibrotic activities by suppressing SUBE3 and TGF-β gene expression.

 

Empiema pada paru dapat menyebabkan terjadinya fibrosis paru yang dapat menyebabkan restriksi pada pergerakan parenkim paru. Epigallocatechin-3-gallate (EGCG) adalah senyawa polifenol paling aktif dalam daun gambir (Uncaria gambir Roxb) yang diketahui dapat menghambat terjadinya fibrosis paru akibat empiema. Tinjauan pustaka ini membahas mengenai peran EGCG dalam menghambat perkembangan fibrosis pleura pada pasien empiema.

EGCG mencegah peningkatan pembentukan ROS yang diinduksi bleomisin, mengembalikan penurunan status antioksidan, dan meningkatkan aktivitas Nrf2. EGCG juga mengurangi penanda peradangan seperti tingkat aktivitas NF-κB, TNFα, IL-1β dan MPO serta mengurangi tanda-tanda histologis peradangan dan cedera paru-paru. EGCG menurunkan kadar hidroksiprolin dan glikokonjugat, produk metabolisme kolagen, mengurangi hidrolase lisosom yang menurunkan matriks, dan memperbaiki perubahan ultrastruktur di paru-paru. EGCG juga melakukan aktivitas antifibrotik dengan menekan ekspresi TGF-β dan gen SCUBE3.

Senyawa EGCG mampu menghambat perkembangan fibrosis paru pada empiema melalui aktivitas antioksidan dan antifibrotik dengan menekan ekspresi gen SUBE3 dan TGF-β.

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How to Cite

Riendra, M., Lipoeto, N. I., Rita, R. S., & Basyar, M. (2024). Peran Epigallocatechin-3-gallate (EGCG) dalam Menghambat Perkembangan Fibrosis Pleura, Ekspresi SCUBE3, dan Transforming Growth Factror-β (TGF-β) pada Pasien Empiema: sebuah tinjauan pustaka. Intisari Sains Medis, 15(1), 495–500. https://doi.org/10.15562/ism.v15i1.2001

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Muhammad Riendra
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Nur Indrawaty Lipoeto
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Rauza Sukma Rita
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Masrul Basyar
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