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The Effectiveness Of Combination Vitamin D With Phototherapy For Vitiligo Treatment


Vitiligo represents a pigmentary skin disorder that impacts the layers of the skin, characterized by the absence of pigmentary cells in the epidermis, which causes the body to develop white patches and macules. However, additional research is necessary to comprehensively grasp the mechanisms that can be obtained using vitamin D with phototherapy for vitiligo treatment. Current evidence indicates that vitamin D substantially influences keratinocytes and melanocytes' activities through various mechanisms. Therefore, this literature review was organized to assess the effectiveness of combining vitamin D with phototherapy for vitiligo treatment. A search was conducted across four electronic journal databases: Google Scholar, PubMed, Taylor & Francis, and ScienceDirect. Inclusion criteria involved studies with vitiligo respondents, explaining the effectiveness of combining vitamin D with phototherapy for vitiligo treatment and detailing the benefits or harms of using this combination in vitiligo patients. Only five studies met the specified criteria and are consequently considered deserving of further assessment. The combination of phototherapy and vitamin D is postulated to manage vitiligo effectively. Phototherapy enhances repigmentation, ensuring a harmonious color reconciliation with the innate skin tone. Simultaneously, Vitamin D assumes a pivotal role in modulating the activity of keratinocytes and melanocytes, operating through diverse mechanisms. Based on this article review, it can be concluded that phototherapy with vitamin D is more effective in treating vitiligo than phototherapy only.


  1. Yousef H, Alhajj M, Sharma S. Anatomy, Skin (Integument), Epidermis. StatPearls [Internet]. 2022 Nov 14 [cited 2023 Dec 12]; Available from:
  2. Weiss MEM. Vitiligo: To biopsy or not to biopsy? Cutis. 2020;105(4):189–90.
  3. Joge RR, Kathane PU, Joshi SH. Vitiligo: A Narrative Review Article. Cureus. 2022;14(9):1–6.
  4. jan NA, Masood S. Vitiligo. StatPearls [Internet]. 2023 Aug 7 [cited 2023 Dec 12]; Available from:
  5. Eleftheriadou V. Reliability and validity of the Vitiligo Signs of Activity Score. Br J Dermatol. 2020;183(5):801–2.
  6. Bergqvist C, Ezzedine K. Vitiligo: A Review. Dermatology. 2020;236(6):571–92.
  7. Ezzedine K, Lim H, Suzuki T, Katayama I, Hamvazi I, Lan C, et al. issues : the Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Research. 2013;25(3):1–28.
  8. Rathod DG, Muneer H, Masood S. Phototherapy. Turkderm Turkish Arch Dermatology Venereol [Internet]. 2023 Feb 16 [cited 2023 Dec 13];56:10–6. Available from:
  9. Pacifico A, Leone G. Photo(chemo)therapy for vitiligo. Photodermatol Photoimmunol Photomed. 2011;27(5):261–77.
  10. Zubair R, Hamzavi IH. Phototherapy for Vitiligo. Dermatol Clin [Internet]. 2020;38(1):55–62. Available from:
  11. Bae JM, Jung HM, Hong BY, Lee JH, Choi WJ, Lee JH, Kim GM. Phototherapy for Vitiligo: A Systematic Review and Meta-analysis. JAMA Dermatology [Internet]. 2017 Jul 1 [cited 2023 Dec 12];153(7):666. Available from: /PMC/articles/PMC5817459/
  12. Norman PE, Powell JT. Vitamin D and cardiovascular disease. Circ Res. 2014;114(2):379–93.
  13. Agostini D, Donati Zeppa S. Vitamin D, Diet and Musculoskeletal Health. Nutrients. 2023;15(13):15–7.
  14. Nopriyati, M. Akip Riyan Saputra, Izazi Hari Purwoko, Theresia L. Toruan. The Role of Topical Vitamin D in Vitiligo: A Narrative Literature Review. Biosci Med J Biomed Transl Res. 2022;6(13):2516–26.
  15. Sawarkar S, Ashtekar A. Transdermal vitamin D supplementation—A potential vitamin D deficiency treatment. J Cosmet Dermatol. 2020;19(1):28–32.
  16. AlGhamdi K, Kumar A, Moussa N. The role of vitamin D in melanogenesis with an emphasis on vitiligo. Indian J Dermatol Venereol Leprol. 2013;79(6):750–8.
  17. Kullavanijaya P, Lim HW. Topical calcipotriene and narrowband ultraviolet B in the treatment of vitiligo. Photodermatol Photoimmunol Photomed. 2004;20(5):248–51.
  18. Goktas EO, Aydin F, Senturk N, Canturk MT, Turanli AY. Combination of narrow band UVB and topical calcipotriol for the treatment of vitiligo. J Eur Acad Dermatology Venereol. 2006;20(5):553–7.
  19. Leone G, Pacifico A, Iacovelli P, Vidolin AP, Picardo M. Tacalcitol and narrowband phototherapy in patients with vitiligo. Clin Exp Dermatol. 2006;31(2):200–5.
  20. Akdeniz N, Yavuz IH, Gunes Bilgili S, Ozaydin Yavuz G, Calka O. Comparison of efficacy of narrow band UVB therapies with UVB alone, in combination with calcipotriol, and with betamethasoneand calcipotriol in vitiligo. J Dermatolog Treat. 2014;25(3):196–9.
  21. Sahu P, Jain VK, Aggarwal K, Kaur S, Dayal S. Tacalcitol: a useful adjunct to narrowband ultraviolet-B phototherapy in vitiligo. Photodermatol Photoimmunol Photomed. 2016;32(5–6):262–8.
  22. Rashighi M, Harris JE. Vitiligo Pathogenesis and Emerging Treatments. Dermatol Clin. 2017;35(2):257–65.
  23. Shen C, Gao J, Sheng Y, Dou J, Zhou F, Zheng X, Ko R, Tang X, Zhu C, Yin X, Sun L, Cui Y, Zhang X. Genetic susceptibility to vitiligo: GWAS approaches for identifying vitiligo susceptibility genes and loci. Front Genet. 2016;7(FEB):1–12.
  24. Gill L, Zarbo A, Isedeh P, Jacobsen G, Lim HW, Hamzavi I. Comorbid autoimmune diseases in patients with vitiligo: A cross-sectional study. J Am Acad Dermatol [Internet]. 2016;74(2):295–302. Available from:
  25. Koca R, Armutcu F, Altinyazar HC, Gürel A. Oxidant-antioxidant enzymes and lipid peroxidation in generalized vitiligo. Clin Exp Dermatol. 2004;29(4):406–9.
  26. Shalbaf M, Gibbons NCJ, Wood JM, Maitland DJ, Rokos H, Elwary SM, Marles LK, Schallreuter KU. Presence of epidermal allantoin further supports oxidative stress in vitiligo. Exp Dermatol. 2008;17(9):761–70.
  27. Dell’Anna ML, Ottaviani M, Albanesi V, Vidolin AP, Leone G, Ferraro C, Cossarizza A, Rossi L, Picardo M. Membrane lipid alterations as a possible basis for melanocyte degeneration in vitiligo. J Invest Dermatol. 2007;127(5):1226–33.
  28. d’Ischia M, Wakamatsu K, Cicoira F, Di Mauro E, Garcia-Borron JC, Commo S, Galván I, Ghanem G, Kenzo K, Meredith P, Pezzella A, Santato C, Sarna T, Simon JD, Zecca L, Zucca FA, Napolitano A, Ito S. Melanins and melanogenesis: From pigment cells to human health and technological applications. Pigment Cell Melanoma Res. 2015;28(5):520–44.
  29. Toosi S, Orlow S, Manga P. Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8. J Invest Dermatol. 2012;132(11):2601–9.
  30. Van Den Boorn JG, Picavet DI, Van Swieten PF, Van Veen HA, Konijnenberg D, Van Veelen PA, Van Capel T, Jong ECD, Reits EA, Drijfhout JW, Bos JD, Melief CJM, Luiten RM. Skin-depigmenting agent monobenzone induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy. J Invest Dermatol [Internet]. 2011;131(6):1240–51. Available from:
  31. Abel EA. Phototherapy. Dermatol Clin. 1995 Oct;13(4):841–9.
  32. Rathod DG, Muneer H, Masood S. Phototherapy. Turkderm Turkish Arch Dermatology Venereol [Internet]. 2023 Feb 16 [cited 2023 Dec 14];56:10–6. Available from:
  33. Guitart J. Psoralen Plus UV-A Therapy in the 21st Century: Use It or Lose It. JAMA Dermatology. 2019;155(5):529–30.
  34. Campbell J. Safe and effective use of phototherapy and photochemotherapy in the treatment of psoriasis. 2020;29(10):547–52.
  35. Yones SS, Palmer RA, Garibaldinos TM, Hawk JLM. Randomized Double-blind Trial of Treatment of Vitiligo. Arch Dermatol. 2007;143(5).
  36. Bhatnagar A, Kanwar AJ, Parsad D, De D. Comparison of systemic PUVA and NB-UVB in the treatment of vitiligo: An open prospective study. J Eur Acad Dermatology Venereol. 2007;21(5):638–42.
  37. Brodsky M, Abrouk M, Lee P, Kelly KM. Revisiting the history and importance of phototherapy in dermatology. JAMA Dermatology. 2017;153(5):435.
  38. Lotti T, Gianfaldoni S, Valle Y, Rovesti M, Feliciano C, Satolli F. Controversial issues in vitiligo patients: a review of old and recent treatments. Dermatol Ther. 2019;32(1).
  39. Naik PP, Farrukh SN. Influence of Ethnicities and Skin Color Variations in Different Populations: A Review. Skin Pharmacol Physiol. 2022;35(2):65–76.
  40. Al-Smadi K, Ali M, Alavi SE, Jin X, Imran M, Leite-Silva VR, Mohammed Y. Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review. Cells. 2023;12(19):1–19.
  41. Birlea SA, Costin G-E, Norris DA. Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation. Curr Drug Targets. 2008 Apr;9(4):345–59.
  42. Mohammed YH, Yamada M, Lin LL, Grice JE, Roberts MS, Raphael AP, Benson HAE, Prow TW. Microneedle Enhanced Delivery of Cosmeceutically Relevant Peptides in Human Skin. PLoS One [Internet]. 2014 Jul 17 [cited 2023 Dec 14];9(7):e101956. Available from:
  43. Lotti T, Gori A, Zanieri F, Colucci R, Moretti S. Vitiligo : new and emerging. Dermatol Ther. 2008;21(5):110–7.
  44. Parsad D, Saini R, Verma N. Combination of PUVAsol and topical calcipotriol in vitiligo. Dermatology. 1998;197(2):167–70.
  45. Bikle DD. Vitamin D: a calciotropic hormone regulating calcium-induced keratinocyte differentiation. J Am Acad Dermatol. 1997 Sep;37(3 Pt 2):S42-52.
  46. Yamanaka KI, Kakeda M, Kitagawa H, Tsuda K, Akeda T, Kurokawa I, Gabazza EC, Kupper TS, Mizutani H. 1,24-Dihydroxyvitamin D3 (tacalcitol) prevents skin T-cell infiltration. Br J Dermatol. 2010;162(6):1206–15.
  47. Katayama I, Ashida M, Maeda A, Eishi K, Murota H, Bae SJ. Open trial of topical tacalcitol [1 alpha 24(OH)2D3] and solar irradiation for vitiligo vulgaris: upregulation of c-Kit mRNA by cultured melanocytes. Eur J Dermatol. 2003;13(4):372–6.
  48. Ngestiningsih D, Dayanti JK, Batubara L. Relationship between il-6, il-1β, and vitamin d on frailty status in elderly women. Bali Med J. 2021;10(1). doi:10.15562/bmj.v10i1.2177

How to Cite

Yadnya, P. A. G. L. K. ., & Saraswaty, P. A. P. . (2023). The Effectiveness Of Combination Vitamin D With Phototherapy For Vitiligo Treatment. Intisari Sains Medis, 14(3), 1275–1280.




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