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Kadar transforming growth factor-β1 yang rendah sebagai faktor risiko preeklampsia

  • I Made Darmayasa ,
  • I Wayan Artana Putra ,
  • Divika Silvana ,
  • I Made Mugi Raharja ,
  • pdf  |
  • Published: 2023-12-26


Introduction: Endothelial dysfunction is one of preeclampsia theories associated with the inflammatory process and an increase in transforming growth factor surface receptors. This study aims to determine whether low TGF-β1 levels are a risk factor for preeclampsia.

Method: The research design used in this research is a case-control study. The research was conducted at the Emergency Room and Midwifery Polyclinic at Prof. Dr. I.G.N.G. Ngoerah Hospital and Clinical Pathology Laboratory Prof. RSUP. Dr. I.G.N.G Ngoerah Denpasar Bali, from February to July 2023. TGF β-1 levels were examined using the enzyme-linked immunosorbent assay (ELISA) method. Data analysis in this study used the chi square test and ods ratio calculation.

Results: The mean TGF-β1 level found in pregnant women with preeclampsia was 181.03, whereas in normal pregnancies the mean was 631.18. TGF-β1 levels were found to be significantly lower in pregnant women with preeclampsia compared to normal pregnancies with an OR value of 4.75 and a p-value <0.05 (p=0.012).

Conclusion: Low levels of TGF-β1 in the serum of pregnant women are a risk factor for preeclampsia. Implications Low TGF-β1 levels describe the incidence of preeclampsia in pregnant women so that it can be an early predictor for detecting preeclampsia


Pendahuluan: Disfungsi endotel merupakan salah satu teori pada preeklampisa yang dikaitkan dengan proses inflamasi dan peningkatan dari reseptor permukaan transforming growth factor. Penelitian ini bertujuan untuk mengetahui apakah kadar TGF-β1 yang rendah merupakan faktor  risiko preeklampsia.

Metode: Rancangan penelitian yang digunakan pada penelitian ini adalah studi kasus kontrol. Penelitian dilakukan di Instalasi Gawat Darurat dan Poliklinik Kebidanan RSUP Prof. Dr. I.G.N.G. Ngoerah dan Laboratorium Patologi Klinik RSUP Prof. Dr. I.G.N.G Ngoerah Denpasar Bali, mulai bulan Februari hingga Juli 2023. Kadar TGF β-1 diperiksa dengan metode enzyme-linked immunosorbent assay (ELISA). Analisis data dalam penelitian ini menggunakan uji chi square dan perhitungan rasio ods.

Hasil: Dijumpai mean kadar TGF-β1 pada ibu hamil dengan preeklampsia yakni 181,03, sedangkan pada kehamilan normal dijumpai mean 631,18. Kadar TGF-β1 dijumpai secara signifikan lebih rendah pada ibu hamil dengan preeklampsia dibandingkan dengan kehamilan normal dengan nilai OR 4.75 dan nilai p<0.05 (p=0.012).

Simpulan: Kadar TGF-β1 yang rendah pada serum ibu hamil merupakan faktor resiko terjadinya preeklampsia. Implikasi Kadar TGF-β1 yang rendah menggambarkan kejadian Preeklampsia pada ibu hamil sehingga dapat menjadi prediktor dini untuk mendeteksi preeklampsia


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How to Cite

Darmayasa, I. M., Putra, I. W. A., Silvana, D. ., & Raharja, I. M. M. . (2023). Kadar transforming growth factor-β1 yang rendah sebagai faktor risiko preeklampsia. Intisari Sains Medis, 14(3), 1327–1330. Retrieved from




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