Skip to main content Skip to main navigation menu Skip to site footer

Pulmonary tuberculoma, to resect or not to resect: a systematic review

  • Devi Agustini Rahayu ,
  • Keyshia N Yazid ,
  • Bermansyah Burhan ,


Introduction: Pulmonary tuberculomas usually present as a solitary pulmonary nodule. Pulmonary tuberculoma is difficult to differentiate from lung cancer. The treatment should follow the multiple disciplinary teams.

Method: This systematic review aims to summarize the effectiveness of pulmonary tuberculoma treatment, including the response to anti-tuberculosis treatment or surgical resection. PubMed, Wiley, Cochrane, ProQuest, and ScienceDirect were searched for any design study that showed the cure rate of pulmonary tuberculoma treatment, with surgical resection or the used of anti-tuberculosis treatment.

Result: Four studies were identified and analyzed from 288 initial articles. Data were then extracted from the studies and summarized descriptively. Two hundred eighty-eight articles were screened, and four studies were identified and eventually selected. The cure rate of pulmonary tuberculoma increased in patients with surgical procedures compared with medical treatment (only anti-tuberculosis treatment). Pulmonary tuberculoma responds poorly to anti-tuberculosis treatment and often requires long-term treatment.

Conclusion: The treatment of tuberculoma with surgical resection works effectively, with better short- and long-term effects for tuberculoma. Surgical resection was effective in increasing the cure rate of pulmonary tuberculoma. Pulmonary resection in combination with post-operative anti-tuberculosis treatment results in excellent cure rate.


  1. Yang SH, Zhan P, Mao HH, et al. Perfusing chemotherapy by percutaneous lung puncture “holing” for pulmonary tuberculoma—a ten-year single center experience. J Thorac Dis. 2013;5:466-471.
  2. Andreu J, Cáceres J, Pallisa E, et al. Radiological manifestations of pulmonary tuberculosis. Eur J Radiol. 2004;51:139-149.
  3. Kikano GE, Fabien A, Schilz R. Evaluation of the Solitary Pulmonary Nodule. Am Fam Physician. 2015;92:1084-1091.
  4. Subotic D, Yablonskiy P, Sulis G, et al. Surgery and pleuro-pulmonary tuberculosis: A scientific literature review. J Thorac Dis. 2016;8:474-485.
  5. Xia Z, Qiao K, He J. Recent advances in the management of pulmonary tuberculoma with focus on the use of tubeless video-assisted thoracoscopic surgery. J Thorac Dis. 2017;9:3307-3312.
  6. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:56-62.
  7. Wallace BC, Kuiper J, Sharma A, et al. Extracting PICO Sentences from Clinical Trial Reports Using Supervised Distant Supervision. J Mach Learn Res. 2016;17:90-98.
  8. Laisaar T, Viiklepp P, Hollo V, et al. Long-Term Follow-up after Thoracoscopic Resection of Solitary Pulmonary Tuberculoma. Indian J Tuberc. 2014;61:51-56.
  9. Giller DB, Giller BD, Giller GV, et al. Treatment of pulmonary tuberculosis: Past and present. Eur J Cardiothorac Surg. 2018;53:967-972.
  10. Li S, Jiang L, Ang KL, et al. New tubeless video-assisted thoracoscopic surgery for small pulmonary nodules. Eur J Cardiothorac Surg. 2017;51:689-693.
  11. Lee HS, Oh JY, Lee JH, et al. Response of pulmonary tuberculomas to anti-tuberculous treatment. Eur Respir J. 2004;23:452-455.
  12. Jeong YJ, Yi CA, Lee KS. Solitary pulmonary nodules: Detection, characterization, and guidance for further diagnostic workup and treatment. Am J Roentgenol. 2007;188:57-68.
  13. Visca D, Tiberi S, Centis R, et al. Post-tuberculosis (TB) treatment: The role of surgery and rehabilitation. Appl Sci. 2020;10:2734-2751.

How to Cite

Rahayu, D. A., Yazid, K. N. ., & Burhan, B. . (2023). Pulmonary tuberculoma, to resect or not to resect: a systematic review. Intisari Sains Medis, 14(3), 1254–1258.




Search Panel

Devi Agustini Rahayu
Google Scholar
ISM Journal

Keyshia N Yazid
Google Scholar
ISM Journal

Bermansyah Burhan
Google Scholar
ISM Journal