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Hubungan antara rasio limfosit monosit preoperatif dengan performance status pasien karsinoma buli



Abstract

Introduction: Bladder carcinoma is a common malignancy in women and is the fourth most common malignancy in men. LMR (Lymphocyte monocyte ratio) is an inexpensive and practical inflammatory biomarker that has been introduced to determine prognosis in the field of urology. The aim of this study was to determine the relationship between preoperative LMR (lymphocyte monocyte ratio) and performance status in bladder cancer patients.

Methods: This study is observational with an analytic cross-sectional study approach. This research was conducted at Sanglah Hospital in Denpasar to collect secondary data in the form of medical records from 2018 to 2022. This study used primary and secondary data derived from questionnaires and medical records.

Results: Based on this study, the mean age of the research sample was 60.56 ± 7.606 years. The LMR cut point value for Performance Status is 2.474. In the ROC curve analysis, the area under the curve was found to be 0.917, with a sensitivity value of 86.36% and a specificity of 95.45%. The results of the bivariate analysis showed that based on the results of the analysis it was found that LMR had a significant relationship to performance status (p <0.001) with a PR value of 133.00 (95% CI = 20.510-86.473). The results of the logistic regression test show that LMR (categorized based on the cut point of 2.474) is significantly related to Performance Status.

Conclusion: Based on the research results show that the LMR value is related to Performance Status as measured using the Karnofsky Score.

 

Pendahuluan: Karsinoma buli adalah keganasan yang umum pada wanita dan merupakan keganasan keempat yang paling umum pada pria. Banyak pemeriksaan biomarker terkait keganasan yang berdasarkan pada gambaran patologis dan marker molecular, namun mahal dan tidak selalu rutin dilakukan sehari-hari. LMR (Lymphocyte monocyte ratio) merupakan salah satu biomarker inflamasi yang murah dan praktis ini mulai diperkenalkan untuk menentukan prognosis di bidang urologi. Tujuan penelitian adalah untuk mengetahui hubungan LMR (lymphocyte monocyte ratio) pre operatif dengan performance status pada pasien karsinoma buli.

Metode: Penelitian ini adalah suatu penelitian observasional dengan pendekatan studi potong lintang analitik. Penelitian ini dilaksanakan di RSUP Sanglah Denpasar untuk melakukan pengambilan data sekunder berupa rekam medis, mulai dari tahun 2018 sampai dengan tahun 2022. Penelitian ini menggunakan data primer dan sekunder  berasal dari kuesioner dan rekam medis.

Hasil: Berdasarkan penelitian ini, rerata usia sampel penelitian adalah sebesar 60,56 ± 7,606 tahun. Nilai titik potong LMR terhadap Performance Status adalah sebesar 2,474. Pada analisis kurva ROC ditemukan nilai area di bawah kurva sebesar 0,917 dengan nilai sensitivitas sebesar 86,36% dan spesifisitas sebesar 95,45%. Hasil analisis bivariat menunjukkan bahwa Berdasarkan hasil analisis ditemukan bahwa LMR memiliki hubungan yang signifikan terhadap performance status (p<0,001) dengan nilai PR sebesar 133,00 (IK 95% = 20,510-86,473). Hasil uji regresi logistik menunjukkan bahwa LMR (dikategorikan berdasarkan titik potong 2,474) berhubungan secara signifikan dengan Performance Status.

Simpulan: Berdasarkan hasil penelitian menunjukkan bahwa nilai LMR berhubungan dengan Performance Status yang diukur dengan menggunakan Karnofsky Score.

Keywords: Karsinoma buli LMR Karnofsky Score

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How to Cite

Andre Ferryandri Susantio, Anak Agung Gde Oka, & I Gede Raka Widiana. (2023). Hubungan antara rasio limfosit monosit preoperatif dengan performance status pasien karsinoma buli. Intisari Sains Medis, 14(2), 776–784. https://doi.org/10.15562/ism.v14i2.1776
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Andre Ferryandri Susantio
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Pubmed
ISM Journal

Anak Agung Gde Oka
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Pubmed
ISM Journal

I Gede Raka Widiana
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Pubmed
ISM Journal