Skip to main content Skip to main navigation menu Skip to site footer

Presepsin as diagnostic test in neonatal sepsis



Abstract

Background: Sepsis is clinical syndrome characterized by hemodynamic, respiratory and metabolic changes resulting from infectious processes that trigger systemic inflammatory response syndrome. The latest diagnosis enforcement of neonatal sepsis in the form of biomarker, presepsin. This research was established to estimate the accuracy of presepsin in diagnosing neonatal sepsis in preterm

Methods: This study is cross-sectional study with diagnostic test design to determine the accuracy of presepsin examination in diagnosing neonatal sepsis with gold standard used double-sided blood culture. Sample size was 62 samples. Data analysis including sensitivity, specificity, positive predictive value, negative predictive value and accuracy of presepsin as diagnostic test calculated by using 2x2 table.

Results: This study involved 62 subjects. Subjects were dominated by median age 3, male 66.1%, birth weight 1500-<2500 grams 53.2%, vigorous baby 51.6%, caesarean section 67.7%, median leukocytes 4.8, median platelets 101.4, median IT-ratio 0.33, procalcitonin 2.21 and positive blood culture 77.4%. The AUC value is 85% and ROC curve showed 2 cut off values, namely 150 pg/mL, 44 subjects suffer neonatal sepsis with sensitivity 91.7%, specificity 78.57%, positive predictive value 93.62%, negative predictive value 73.3%, positive trend ratio 4.28, prevalence 77% and accuracy 88.71%. Cut off 243 pg/mL sensitivity 75%, specificity 85.7%, positive predictive value 94.6%, negative predictive value 50.6%, positive trend ratio 5.25, prevalence 77% and accuracy 77.46%.

Conclusion:  A cut off value 150 pg/mL, sensitivity 91.67% presepsin can be used as screening tool and cut off 243 pg/mL with specificity 85.7% as high specificity diagnostic test.

Keywords: presepsin neonatal sepsis premature diagnostic test

References

  1. Ozdemir AA, Elgormus Y. Diagnostic Value of Presepsin in Detection of Early-Onset Neonatal Sepsis. Am J Perinatol. 2017;34(6):550-556. doi: 10.1055/s-0036-1593851. Epub 2016 Nov 8. PMID: 27825177.
  2. Desai, P. P., Shah, A. N., Pandya, T., Desai, P., & Pandya, T. C-Reactive Protein, Immature to total Neutrophil Ratio and Micro ESR in early diagnosis of Neonatal Sepsis. International Journal of Biomedical and Advance Research. 2014;5(8): 364.
  3. Meisner M. Pathobiochemistry and clinical use of procalcitonin. Clin Chim Acta. 2002;323(1-2):17-29. doi: 10.1016/s0009-8981(02)00101-8. PMID: 12135804.
  4. Park IH, Lee SH, Yu ST, Oh YK. Serum procalcitonin as a diagnostic marker of neonatal sepsis. Korean J Pediatr. 2014;57(10):451-6. doi: 10.3345/kjp.2014.57.10.451. Epub 2014 Oct 31. PMID: 25379046; PMCID: PMC4219948.
  5. Bujang MA, Adnan TH. Requirements for Minimum Sample Size for Sensitivity and Specificity Analysis. J Clin Diagn Res. 2016;10(10):YE01-YE06. doi: 10.7860/JCDR/2016/18129.8744. Epub 2016 Oct 1. PMID: 27891446; PMCID: PMC5121784.
  6. Topcuoglu S, Arslanbuga C, Gursoy T, Aktas A, Karatekin G, Uluhan R, Ovali F. Role of presepsin in the diagnosis of late-onset neonatal sepsis in preterm infants. J Matern Fetal Neonatal Med. 2016;29(11):1834-9. doi: 10.3109/14767058.2015.1064885. Epub 2015 Jul 30. PMID: 26135765.
  7. Shreffler, J. and Huecker, M. R., 2020. Diagnostik Testing Accuracy: Sensitivity, Specificity, Predictive Values and Likelihood Ratios, StatPearls.
  8. Liu B, Chen YX, Yin Q, Zhao YZ, Li CS. Diagnostic value and prognostic evaluation of Presepsin for sepsis in an emergency department. Crit Care. 2013;17(5):R244. doi: 10.1186/cc13070. PMID: 24138799; PMCID: PMC4056322.
  9. Behnes M, Bertsch T, Lepiorz D, Lang S, Trinkmann F, Brueckmann M, Borggrefe M, Hoffmann U. Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment. Crit Care. 2014;18(5):507. doi: 10.1186/s13054-014-0507-z. PMID: 25190134; PMCID: PMC4174283.
  10. Vodnik T, Kaljevic G, Tadic T, Majkic-Singh N. Presepsin (sCD14-ST) in preoperative diagnosis of abdominal sepsis. Clin Chem Lab Med. 2013;51(10):2053-62. doi: 10.1515/cclm-2013-0061. PMID: 23740685.
  11. Ming-hua, S. 2014. Prognostic value of presepsin for diagnosis and severity assessment of sepsis. Chin J Clin Lab Sci, 32, pp. 106–111.
  12. Aliu-Bejta A, Atelj A, Kurshumliu M, Dreshaj S, Baršić B. Presepsin values as markers of severity of sepsis. Int J Infect Dis. 2020;95:1-7. doi: 10.1016/j.ijid.2020.03.057. PMID: 32251795.
  13. Park JE, Lee B, Yoon SJ, Park CM, Jung CW, Ahn MJ, Park HD, Hwang SY, Shin TG, Kang ES. Complementary Use of Presepsin with the Sepsis-3 Criteria Improved Identification of High-Risk Patients with Suspected Sepsis. Biomedicines. 2021 24;9(9):1076. doi: 10.3390/biomedicines9091076. PMID: 34572261; PMCID: PMC8469631.

How to Cite

Artana, L. M. D. W. ., Putra, P. J. ., Hartawan, I. N. B. ., Purniti, N. P. S. ., Sidiartha, I. G. L. ., & Mayangsari, A. S. M. . (2023). Presepsin as diagnostic test in neonatal sepsis. Intisari Sains Medis, 14(2), 897–902. https://doi.org/10.15562/ism.v14i2.1760
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
0

Total
0

Share

Search Panel

Luh Made Diah Wulandari Artana
Google Scholar
Pubmed
ISM Journal

Putu Junara Putra
Google Scholar
Pubmed
ISM Journal

I Nyoman Budi Hartawan
Google Scholar
Pubmed
ISM Journal

Ni Putu Siadi Purniti
Google Scholar
Pubmed
ISM Journal

I Gusti Lanang Sidiartha
Google Scholar
Pubmed
ISM Journal

Ayu Setyorini Mestika Mayangsari
Google Scholar
Pubmed
ISM Journal