Monkeypox (mpox), part of orthopoxvirus, is a viral zoonosis that broke out outside Africa in 2022 and has become a global health concern. Most of the cases are affected by the gay or bisexual community. It can be transmitted from animal to human or between humans. The most common symptoms of monkeypox are fever, lethargy, myalgia, headache, and lymphadenopathy. The most accurate and sensitive diagnostic assay is real-time polymerase chain reaction (PCR). Two types of vaccine can be used to prevent orthopoxvirus: 1) live and non-replicating vaccine (JYNNEOS®) and 2) live replicating vaccinia virus vaccine (ACAM2000®). Monkeypox is a self-limiting disease and only needs symptomatic medication, for individuals with immunocompromised conditions or severe monkeypox infection can be given antivirus such as cidofovir, brincidofovir, and tecovirimat. This review will explain monkeypox treatment and prevention.