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Prevalence of colorectal carcinoma based on microscopic type, sex, age and anatomical location in Sanglah General Hospital

Abstract

Background: Colorectal carcinoma (CRC) is a disease in which epithelial cells in the colon or rectum become abnormal and divide without control, forming a mass called a tumor. Colorectal carcinoma is the fourth most frequent cancer in men after prostate and lung or bronchus cancers whereas in women is the third most frequent cancer after breast and lung or bronchus cancers. Colorectal cancer is a leading cause of cancer death worldwide, accounting for 693,900 deaths in 2012 and is the fourth most frequent cancer in men whereas in women is the third most frequent cancer. In Indonesia amount of rectal cancer were 1407 (5.67%) and 990 cases (3.99%) of colon cancer. Specifically in Denpasar, there are a total of 75 cases (7.11%) of rectal cancer and 38 cases (3.60%) of colon cancer in the year.

Aim: This study aims to know the prevalence of colorectal carcinoma based on microscopic type, sex, age and anatomical location in Sanglah General Hospital in Denpasar from January 2014 to January 2016.

Method: This study used descriptive retrospective research based on the secondary data from patients medical record which was taken at Sanglah General Hospital from January 2014 to January 2016. Population and sample amounted to 275 patients.

Results: This study shows that the highest prevalence of colorectal carcinoma was in a group of age <50 years old with 86 samples (31.3%) and in a male with 163 samples (59.3%). Adenocarcinoma has the highest prevalence of colorectal carcinoma with 270 samples (98.2%). The rectum was the most frequent tumor location with 170 samples (61.8%). In adenocarcinoma, the age group with the highest prevalence of CRC was <50 years with 85 samples (30.9%). The highest prevalence of CRC based on anatomical location and age group was <50 years in the rectum with 57 samples (20.7%).

Conclusion: Most of the CRC was found in age group < 50 years, men had a higher risk to get colorectal carcinoma, adenocarcinoma is the most common microscopic type, and rectum was the most common site of colorectal carcinoma.

References

  1. Bhandari, A., Woodhouse, M., and Gupta, S. Colorectal cancer is a leading cause of cancer incidence and mortality among adults younger than 50 years in the USA: a SEER-based analysis with comparison to other young-onset cancers. Journal of Investigative Medicine 2016; 65(2): 311-31
  2. Bosman F. WHO classification of tumours of the digestive system. 4th ed. Lyon, France.: IARC Press; 2010.
  3. Fleming, M., Ravula, S., Tatishchev, S. and Wang, H. Colorectal carcinoma: Pathologic aspects. Journal of Gastrointestinal Oncology 2012; 3(3): 153-173.
  4. Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C. and Parkin, D. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer 2010; 127(12): 2893-2917.
  5. Direktorat Jendral Pelayanan Medik. 2012. Kanker di Indonesia Tahun 2011. Data Histopatologik. Jakarta: Department Kesehatan R.I
  6. Siegel, R., DeSantis, C. and Jemal, A. Colorectal cancer statistics, 2014. CA: A Cancer Journal for Clinicians 2014; 64(2): 104-117.
  7. Seer.cancer.gov. (2017). SEER ICD-O-3 Coding Materials. [online] Available at: http://seer.cancer.gov/icd-o-3/.
  8. Moini, J. 2015. Anatomy and physiology for health professionals. 2nd ed. Burlington: Jones & Bartlett Publishers.
  9. Stewart, S., Wike, J., Kato, I., Lewis, D. and Michaud, F. A population-based study of colorectal cancer histology in the United States, 1998–2001. Cancer 2006; 107(S5): 1128-1141.
  10. Haggar, F. and Boushey, R. Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors. Clinics in Colon and Rectal Surgery 2009; 22(04): 191-197.
  11. Ahnen, D., Wade, S., Jones, W., Sifri, R., Mendoza Silveiras, J., Greenamyer, J., Guiffre, S., Axilbund, J., Spiegel, A. and You, Y. The Increasing Incidence of Young-Onset Colorectal Cancer: A Call to Action. Mayo Clinic Proceedings 2014; 89(2): 216-224.
  12. Goodman, B. Insights into digestion and absorption of major nutrients in humans. AJP: Advances in Physiology Education 2010; 34(2): 44-53.
  13. Murphy, C., Lund, J. and Sandler, R.. Young-Onset Colorectal Cancer: Earlier Diagnoses or Increasing Disease Burden?. Gastroenterology 2017; 152(8): 1809-1812.
  14. Molenaar, R., Radivoyevitch, T. and Wilmink, J. RE: Colorectal Cancer Incidence Patterns in the United States, 1974–2013. JNCI: Journal of the National Cancer Institute; 2017: 109(8).
  15. Lin, J., Zhang, S., Rexrode, K., Manson, J., Chan, A., Wu, K., Tworoger, S., Hankinson, S., Fuchs, C., Gaziano, J., Buring, J. and Giovannucci, E. (2013). Association Between Sex Hormones and Colorectal Cancer Risk in Men and Women. Clinical Gastroenterology and Hepatology 2013; 11(4): 419-424.e1.
  16. Shan Lin, H. and Turner, D. The Benefit and Tolerability of Adjuvant Chemotherapy in Elderly Stage III Colon Cancer Patients: A 3 Year Retrospective Audit. Journal of Gerontology & Geriatric Research 2016; 5(4).
  17. Tan, Y., Fu, J., Li, X., Yang, J., Jiang, M., Ding, K., Xu, J., Li, J. and Yuan, Y. A Minor (<50%) Signet-Ring Cell Component Associated with Poor Prognosis in Colorectal Cancer Patients: A 26-Year Retrospective Study in China. PLOS ONE 2015; 10(3): 1-14.
  18. Dyson, T. and Draganov, P. Squamous cell cancer of the rectum. World Journal of Gastroenterology 2009; 15(35): 4380.
  19. Siegel, R., Miller, K., Fedewa, S., Ahnen, D., Meester, R., Barzi, A. and Jemal, A. Colorectal cancer statistics, 2017. CA: A Cancer Journal for Clinicians 2017: 67(3): 177-193.
  20. Wirata, G., Santoso, P.N.C., Dewantari, P.A.U. 2018. Microstructural aspect of pineal body: the population of pinealocytes. Intisari Sains Medis 9(1): 25-30. DOI: 10.1556/ism.v9i1.151
  21. Nistal, E., Fernández-Fernández, N., Vivas, S. and Olcoz, J. Factors Determining Colorectal Cancer: The Role of the Intestinal Microbiota. Frontiers in Oncology 2015; 5: 1-10.
  22. Benmoussa, A., Zamiati, S., Badre, W., Wakadi, A., Bennani, N., Tahiri Jouti, N. and Nadifi, S. Colorectal cancer: Comparison of clinicopathologic features between Moroccans patients less than 50 years old and older. Pathologie Biologie 2013; 61(3): 117-119.

How to Cite

Anthonysamy, M. A., Indrayani Maker, L. P. lin, Gotra, I. M., & Saputra, H. (2020). Prevalence of colorectal carcinoma based on microscopic type, sex, age and anatomical location in Sanglah General Hospital. Intisari Sains Medis, 11(1), 272–276. https://doi.org/10.15562/ism.v10i2.171

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Michelle Anne Anthonysamy
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Luh Putu lin Indrayani Maker
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I Made Gotra
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Herman Saputra
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