Background: Neonatal sepsis has the main cause of mortality and morbidity in neonates worldwide; the most frequent cause is bacteria. This study examined the bacterial patterns and antibiotic susceptibility in neonatal sepsis at Prof Ngoerah Hospital, Bali.
Methods: This observational, descriptive study was conducted in Prof Ngoerah Hospital, Bali, Indonesia involving neonatal sepsis confirmed with blood culture. Data on antibiotic susceptibility and bacterial patterns were collected retrospectively from the registry of neonates patients with neonatal sepsis from January 2021 to August 2022.
Results: The predominance of gram-negative bacteria was Acinetobacter baumannii (29.17%), Klebsiella pneumonia (10.42%), and the predominance of gram-positive bacteria was Staphylococcus haemolyticus (14.58%), Staphylococcus epidermidis (8.35%). The susceptibility was Gentamicin (57.29%), Ciprofloxacin (56.84%), Levofloxacin (55.21%), Trimethoprim/sulfamethoxazole (54.17%), Amikacin (50%), Meropenem (39.58%), Ampicilin/sulbactam (34.38%), Cefepim (32.29%), Piperacillin/Tazobactam (28.13%), Cefoperazone sulbactam (25%), Tigecycline (25%), Ceftriaxone (23.96%), and Vancomycin (22.92%).
Conclusion: Gram-negative bacteria were a common infection. This study suggests that the reconsideration of gentamicin still can be an option as an empirical antibiotic, but ampicillin has low sensitivity; another broad-spectrum antibiotic with better sensitivity is another option due to its significantly higher susceptibility.