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Sintesa nanopartikel senyawa bioaktif ekstrak etanol kulit kayu manis dengan teknik emulsi spontan di dalam ruang tabung gelas berdiameter 500 μm



Abstract

Background: The bioactive compounds material sourced from cinnamon has many benefits, especially as a medicinal ingredient. Therefore, this material has enormous potential to be developed in the future as a raw material for medicine. However, due to its hydrophobic nature, low chemical stability, easily degraded, and has relatively large particle size, its use is constrained. To overcome these problems, emulsifying of these bioactive compounds with a surfactant and making it nanometer in size, has been carried out.

Method: The cinnamon bark bioactive compounds nanoparticles were synthesized by spontaneous emulsion technique using tween 80 surfactant in a cylindrical chamber with a diameter of 500 μm and a length of 50 cm.

Results: The bioactive compounds contained in cinnamon bark are: (1) cinnamaldehyde (68%), (2) bornylester of acrylic acid (10,31%), (3) alpha-copaene (3,32%), (4) cumarine (12,30%), and (5) methyl isoheptadecanoate (5.25%). Synthesized using four different concentrate masses of these compounds, namely: 4 mg, 6 mg, 8 mg and 10 mg dissolved in 100 ml of ethanol, resulting in an average nanoparticle diameter of: 11.0 nm; 12.1nm; 12.5nm; and 13.9 nm. The polydispersity indices of the synthesized nanoparticles in each synthesis process are 0,292; 0,300; 0,215; dan 0,313.

Conclusion:  From the data obtained, it shows that the greater the mass of the concentrate used, the greater the average diameter of the resulting nanoparticles. The relationship is linear. The same thing happened to the polydispersity index. The value of the polydispersity index increases when the concentrate mass used increases.

 

Latar Belakang: Material senyawa bioaktif yang bersumber dari kulit kayu manis (cinnamon) memiliki banyak manfaat terutama sebagai bahan obat-obatan. Oleh karena itu material senyawa bioaktif ini memiliki potensi yang sangat besar untuk dikembangkan ke depan sebagai bahan baku obat. Namun, karena sifatnya yang hidrofobik, stabilitas kimianya yang rendah, mudah terdegradasi, dan ukuran partikelnya yang relatif besar, penggunaannya mengalami kendala. Untuk mengatasi masalah ini suatu pendekatan mengemulsi senyawa bioaktif tersebut dengan suatu surfaktan dan membuat ukurannya berorde nanometer, telah dilakukan.

Metode: Untuk menghasilkan partikel senyawa bioaktif kulit kayu manis berukuran nanometer, sintesa dengan teknik emulsi spontan dengan menggunakan surfaktan tween 80, telah dilakukan di dalam suatu ruang berbentuk tabung berdiameter 500 μm dan panjang 50 cm.

Hasil: Dari hasil identifikasi, senyawa bioaktif yang terkandung di dalam kulit kayu manis adalah: (1) cinnamaldehyde (68%), (2) bornylester of acrylic acid (10,31%), (3) alpha-copaene (3,32%), (4) cumarine (12,30%), dan (5) methyl isoheptadecanoate (5,25%). Sintesa dengan menggunakan empat ragam massa konsentrat dari senyawa-senyawa tersebut, yaitu: 4 mg, 6 mg, 8 mg dan 10 mg yang dilarutkan ke dalam 100 ml etanol, menghasilkan diameter rata-rata nanopartikel masing-masing sebesar 11,0 nm; 12,1 nm; 12,5 nm; dan 13,9 nm. Indeks polidispersitasnya masing-masing sebesar 0,292; 0,300; 0,215; dan 0,313.

Simpulan: Dari data yang diperoleh menunjukkan bahwa semakin besar massa konsentrat yang digunakan, semakin besar pula diameter rata-rata nanopartikel yang dihasilkan. Hubungannya bersifat linier. Hal yang sama terjadi pada indeks polidispersitasnya. Nilai indeks polidispersitas semakin besar ketika massa konsentrat yang digunakan semakin besar.

Keywords: Sintesa nanopartikel senyawa bioaktif ekstrak etanol kulit kayu manis emulsi spontan tabung gelas

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How to Cite

Manullang, M. V., & Saragih, H. (2023). Sintesa nanopartikel senyawa bioaktif ekstrak etanol kulit kayu manis dengan teknik emulsi spontan di dalam ruang tabung gelas berdiameter 500 μm. Intisari Sains Medis, 14(1), 329–338. https://doi.org/10.15562/ism.v14i1.1639
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Maria Vani Manullang
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ISM Journal

Horasdia Saragih
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ISM Journal