Research Article

Risk factors of preeclampsia and eclampsia in Sanglah General Hospital from March 2016 to March 2017

Ng Teng Fung Vincent , I Made Darmayasa, Anom Suardika

Ng Teng Fung Vincent
Medical Bachelor Program, Faculty of Medicine, Udayana University. Email:

I Made Darmayasa
Department of Obstetric and Gynecology, Sanglah General Hospital, Udayana University

Anom Suardika
Department of Obstetric and Gynecology, Sanglah General Hospital, Udayana University
Online First: May 01, 2018 | Cite this Article
Vincent, N., Darmayasa, I., Suardika, A. 2018. Risk factors of preeclampsia and eclampsia in Sanglah General Hospital from March 2016 to March 2017. Intisari Sains Medis 9(2). DOI:10.15562/ism.v%vi%i.162

Background: Preeclampsia and eclampsia have been increasing at an alarming rate. It is a challenging task for doctors and pregnant mothers. Preeclampsia defined as new onset of hypertension (≥140mmHg systolic or ≥90mm Hg diastolic on at least two occasions 6 hours apart) and proteinuria (at least 1+ on dipstick or ≥300mg in a 24-hour urine collection) after 20 weeks of gestation. Eclampsia defined as neurologic involvement in the form of generalized tonic-clonic convulsions in women with preeclampsia is termed eclampsia if the seizures cannot be attributed to any other cause such as epilepsy, cerebral infection, tumor or ruptured aneurysm. Aim: This study aims to find the association of risk factors for preeclampsia and eclampsia. The risk factors for preeclampsia and eclampsia are obesity, primigravida, multiple pregnancies, diabetes, pre-existing hypertension, family history, expecting mother’s age, nutritional status, and socioeconomic status. The study was carried out by using descriptive research and data were collected from medical records in Sanglah hospital which has 140 cases. Results: The results for preeclampsia are highest in expecting the age of 20-35 years old, primigravida women with gestational age > 37 weeks, overweight and overnourished women, a middle socioeconomic status and also without risk factors. The results for eclampsia are dominant in expecting age of 20-35 years old, primigravida women with gestational age > 37 weeks, women with middle socioeconomic status and majority without risk factors, and women who are overweight and overnourished. Conclusion: Preeclampsia and eclampsia cases are highest in expecting age of 20-35 years old, primigravida women with gestational age >37 weeks, overweight and overnourished women, majority women without risk factors and from middle socioeconomic status.




Ahmadi, S.A.Y., Shahsavar, F., Hasanvand, A. 2016. Controversies on Preeclampsia through the lens of Reproductive Immunology: A Systematic Review. Int J Integr Med Sci. 3(2), pp. 225–228.

American Heart Association. 2017. Understanding Blood Pressure Readings. [Internet]. Texas: American Heart Association. Available at: [Accessed: 19 February 2017].

Andriani, C., Lipoeto, N.I., Utama, B.I. 2013. Hubungan Indeks Massa Tubuh dengan Kejadian Preeklampsia di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas. 5, pp. 173–178.

Angsar M.D. Hipertensi Dalam Kehamilan. 2016. In: Saifuddin A.B., Rachimhadhi T., Wiknjosastro G.H., eds. Ilmu Kebidanan Sarwono Prawirohardjo. Jakarta: Pt Bina Pustaka Sarwono Prawirohardjo, pp. 530-561.

Astuti S.F. 2015. Faktor-Faktor Yang Berhubungan Dengan Kejadian Preeklampsia Kehamilan di Wilayah Kerja Puskesmaspamulang Kota Tangerang Selatan Tahun 2014-2015.

Battinelli, E.M., Marshall, A., Connors, J.M. 2013. The Role of Thrombophilia in Pregnancy. Thrombosis. 2013:516420.

Bdolah, Y., Lam, C., Rajakumar, A., Shivalingappa, V., Mutter, W., Sachs, B.P., Lim, K.H., Bdolah-Abram, T., Epstein, F.H., Karumanchi, S.A. 2008. Twin Pregnancy and the Risk of Preeclampsia: Bigger Placenta or Relative Ischemia? Am J Obstet Gynecol. 198(4):428.e1-428.e6.

Bereketoǧlu, C., Kasap, M., Pazarbaşi, A. 2012. Studies on Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Genotype Distributions in Turkish Preeclampsia Patients. J Pregnancy. 2012:108206

Bilano, V.L., Ota, E., Ganchimeg, T., Mori, R., Souza, J.P. 2014. Risk Factors of Pre-Eclampsia/Eclampsia and Its Adverse Outcomes in Low- and Middle-Income Countries: A WHO Secondary Analysis. PLOS One. 9(3):e91198

Boghossian, N.S., Yeung, E., Mendola, P., Hinkle, S.N., Laughon, S.K., Zhang, C., Albert, P.S. 2014. Risk Factors Differ between Recurrent and Incident Preeclampsia: A Hospital-based Cohort Study. Annals of Epidemiology. 24(12):871-7e3

Borton C., Harding M., Willacy H. 2016. Multiple Pregnancy [Internet]. England: Patient. Available at: [Accessed: 26 January 2017]

Bujold, E. et al. 2010. Prevention of Preeclampsia and Intrauterine Growth Restriction With Aspirin Started in Early Pregnancy. Obstet Gynecol. 116(2, Part 1), pp. 402–414

Callahan, T.L., Caughey, A.B. Hypertension and Pregnancy. 2013. In: Callahan T.L., Caughey A.B., eds. Blueprints in Obstetrics and Gynecology. 6th ed. Philadelphia: Lippincott Williams & Wilkins. pp. 111-119

Centers for Disease Control and Prevention, 2016. Defining Adult Overweight and Obesity [Online]. United States: Centers for Disease Control and Prevention. Available at: [Accessed: 25 January 2017].

Djannah, S.N., Arianti, I.S. 2010. Gambaran Epidemiologi Kejadian Preeklampsia/Eklampsia di RSU PKU Muhammadiyah Yogyakarta Tahun 2007-2009. Buletin Penelitian Sistem Kesehatan. 13(4), pp.378–385.

El-Moselhy E.A., Khalifa H.O., Amer S.M., Mohammad K.IK, El-Aal H.A.M. 2011. Risk Factors and Impacts of Pre-Eclampsia: An Epidemiological Study among Pregnant Mothers in Cairo. Egypt J Am Sci. 77, pp.311–323.

Elok, F., Hendrati, L.Y. 2014. Hubungan Karakteristik Ibu, ANC dan Kepatuhan Perawatan Ibu Hamil dengan Terjadinya Preeklampsia. Jurnal Berkala Epidemiologi. 2(2), pp.216–226.

Endeshaw, M., Abebe, F., Worku, S., Menber, L., Assress, M., Assefa, M. 2016. Obesity in Young Age is a Risk Factor for Preeclampsia: A Facility Based Case-Control Study, Northwest Ethiopia. BMC Pregnancy Childbirth 16: 237.

Endeshaw, M., Ambaw, F., Aragaw, A., Ayalew, A. 2014. Effect of Maternal Nutrition and Dietary Habits on Preeclampsia: A Case-Control Study. Int J Clin Med. 5(21), pp.1405–1416.

Feig, D.S., Shah, B.R., Lipscombe, L.L., Wu, C.F., Ray, J.G., Lowe, J., Hwee, J., Booth, G.L. 2013. Preeclampsia as a Risk Factor for Diabetes: A Population-Based Cohort Study. PLoS Med. 10(4):e1001425.

Genetics Home Reference. Why is it Important to Know My Family Medical History? Genetics Home Reference [Internet]. [cited 2017 Feb 10]. Available from:

Hansson, S.R., Nääv, Å., Erlandsson, L. 2014. Oxidative Stress in Preeclampsia and The Role of Free Fetal Hemoglobin. Front Physiol. 5:516.

Hutcheon, J.A., Lisonkova, S., Joseph, K.S. 2011. Epidemiology of Pre-eclampsia and the Other Hypertensive Disorders of Pregnancy. Best Practice & Research Clinical Obstetrics and Gynaecolology. 25(4), pp.391–403

Imdad, A., Jabeen, A., Bhutta, Z.A. 2011. Role of Calcium Supplementation During Pregnancy in Reducing Risk of Developing Gestational Hypertensive Disorders: A Meta-Analysis of Studies from Developing Countries. BMC Public Health. 11 Suppl 3: S18.

Indriani, N. 2012. Analisis Faktor-faktor yang Berhubungan dengan Preklampsia/Eklampsia pada Ibu Bersalin di Rumah Sakit Umum Daerah Kardinal Kota Tegal Tahun 2011.

Itoh H., Kanayama N. 2014. Obesity and Risk of Preeclampsia. Med J Obstet Gynecol. 2(2):1024.

Jeyabalan, A. 2013. Epidemiology of Preeclampsia: Impact of Obesity. Nutr Rev. 71 Suppl 1:S18-25.

K, R., Gandhi, S., Rao, V. 2014. Socio-Demographic and Other Risk Factors of Pre eclampsia At A Tertiary Care Hospital, Karnataka: Case Control Study. J Clin Diagn Res. 2014 Sep;8(9):JC01-4

Lamminpää R., Vehviläinen-Julkunen K, Gissler M., Heinonen S. 2012. Preeclampsia Complicated by Advanced Maternal Age: A Registry-Based Study on Primiparous Women in Finland 1997–2008. BMC Pregnancy Childbirth. 12(1):47.

Lazarov S., Lazarov L., Lazarov N. 2016. Complications of Mutiple Pregnancies Overwiew. Trakia Journal of Sciences. 14(1), pp.108–111

Makbruri, 2015. Faktor Risiko yang Memengaruhi Berat Badan Lahir Rendah dan Sangat Rendah di Kecamatan Seberang Ulu II Kota Palembang Periode 1 Januari-31 Desember 2008. Jurnal Gradien. 11(1), pp.1079–1084.

Maynard, S.E., Karumanchi, S.A., 2011. Angiogenic Factors and Preeclampsia. Semin Nephrol. 31(1), pp.33–46.

Mayo Clinic. 2014. Diabetes: Tests and Diagnosis. [Internet]. Rochester: Mayo Clinic. Available at: [Accessed: 21 February 2017].

Novianti H. 2016. Pengaruh Usia Dan Paritas Terhadap Kejadian Pre Eklampsia Di RSUD Sidoarjo. Journal of Health Sciences. 9(1).

Oxford Concise Colour Medical Dictionary.5th ed. 2010. Oxford: Oxford University Press. Nutrition. p.508.

Palupi, D.D., Indawati, R. 2014. Faktor Risiko Kematian Ibu dengan Preeklampsia / Eklampsia dan Perdarahan di Provinsi Jawa Timur. Jurnal Biometrika dan Kependudukan. 3(2), pp.107–113.

Poonyth, L., Sobhee, R., Soomaree, R. 2003. Epidemiology of Preeclampsia in Mauritius Island. Journal of Reproductive Immunology. 59, pp. 101–109.

Powe, C.E., Seely, E.W., Rana, S., Bhan, I., Ecker, J., Karumanchi, S.A., Thadhani, R. 2010. First Trimester Vitamin D, Vitamin D Binding Protein, and Subsequent Preeclampsia. Hypertension. 56(4), pp.758–763.

Radjamuda N., Montolalu A. 2014. Faktor-Faktor Risiko Yang Berhubungan Dengan Kejadian Hipertensi Pada Ibu Hamil Di Poli Klinik Obs-Gin Rumah Sakit Jiwa Prof. Dr. V. L. Ratumbuysang Kota Manado. Jurnal Ilmiah Bidan. 2(1), pp.33–40.

Rizki M.E. 2014. Hubungan Usia Dengan Kejadian Preeklampsia Pada Ibu Bersalin Di RSUD Wonosari Tahun 2013.Sekolah Tinggi Ilmu Kesehatan Aisyiyah Yogyakarta.

Roberts, J.M., Bodnar, L.M., Patrick, T.E., Powers, R.W.2011. The Role of Obesity in Preeclampsia. Pregnancy Hypertens. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 1(1), pp.6–16.

Rossi, A.C., Mullin, P.M. 2011. Prevention of Pre-eclampsia With Low-dose Aspirin or Vitamins C and E in Women at High or Low Risk: A Systematic Review With Meta-Analysis. Eur J Obstet Gynecol Reprod Biol. 158(1), pp.9–16.

Rozikhan. 2007. Faktor Faktor Risiko Terjadinya Preeklampsia Berat Di Rumah Sakit Dr. H. Soewondo Kendal. Undip E-Journal System Portal.

Sánchez-Aranguren L.C., Prada C.E., Riaño-Medina C.E., Lopez M. 2014. Endothelial Dysfunction and Preeclampsia: Role of Oxidative Stress. Front Physiol. 5:372.

Saxena P., Kadem V.K. 2015. Obesity in Pregnancy. AOGD Bulletin. 14, pp.6-8.

Shamsi U., Saleem S., Nishter N. 2013. Epidemiology and Risk Factors of Preeclampsia; an Overview of Observational Studies. Al Ameen J Med Sci. 6(4), pp.292-300

Shand A., Nassar N., Von Dadelszen P., Innis S., Green T. 2010. Maternal Vitamin D Status in Pregnancy and Adverse Pregnancy Outcomes in A Group at High Risk For Pre-eclampsia. BJOG. 117(13), pp.1593–1598.

Silva, L.M., Coolman, M., Steegers, E.A., Jaddoe, V.W., Moll, H.A., Hofman, A., Mackenbach, J.P., Raat, H. 2008. Low Socioeconomic Status is a Risk Factor for Preeclampsia: The Generation R Study. J Hypertens. 26(6), pp.1200–1208.

Sonia G., Yolanda F., Mirani P. 2015. Angka Kejadian Persalinan Preterm pada Ibu dengan Preeklampsia Berat dan Eklampsia di RSUP Dr . Mohammad Hoesin Palembang Tahun 2013. MKS. 47(1), pp.31–34.

Tan K.H., Kwek K., Yeo G.S.H. 2006. Epidemiology of Pre-eclampsia and Eclampsia at The KK Women’s and Children’s Hospital, Singapore. Singapore Med J. 47(1), pp.48–53.

Thornton, C., Dahlen, H., Korda, A., Hennessy, A. 2013. The Incidence of Preeclampsia and Eclampsia and associated Maternal Mortality in Australia from Population-Linked Datasets: 2000-2008. Am J Obstet Gynecol. 2013;208(6):476.e1-5.

Trogstad, L., Magnus, P., Stoltenberg, C., 2011. Pre-eclampsia: Risk factors and Causal Models. Best Practice & Research Clinical Obstetrics and Gynaecology. 25(3), pp. 329–342.

Ververs M., Antierens A, Sackl A, Staderini N, Captier V. 2013. Which Anthropometric Indicators Identify a Pregnant Woman as Acutely Malnourished and Predict Adverse Birth Outcomes in the Humanitarian Context?. PLOS Currents Disasters.

Wang X., Bai T., Liu S., Pan H., Wang B. 2014. Association Between Thrombophilia Gene Polymorphisms And Preeclampsia: A Meta-Analysis. PLOS One. 9(6):e100789.

Warouw P.C., Suparman E., Wagey F.W. 2016. Karakteristik Preeklampsia di RSUP Prof. Dr. R. D. Kandou Manado. Jurnal e-Clinic. 4(1), pp.375-379

Wei, S., Audibert, F., Hidiroglou, N., Sarafin, K., Julien, P., Wu, Y., Luo, Z., Fraser, W. 2012. Longitudinal Vitamin D Status in Pregnancy and The Risk of Pre-eclampsia. BJOG. 119(7), pp.832–839

Weissgerber T.L., Mudd L.M. 2015. Preeclampsia And Diabetes. Curr Diab Rep. 15(3):579

World Health Organization. 2016. Obesity and overweight [Internet]. World Health Organization. Available at : [Accessed: 11 December 2016]

Williams P.J., Pipkin F.B. 2011. The Genetics of Pre-eclampsia and Other Hypertensive Disorders Of Pregnancy. Best Pract Res Clin Obstet Gynaecol. 25(4),pp.405–417

Wuryandari, A.G. 2012. Faktor-faktor Yang Berhubungan Dengan Kejadian Pre-Eklampsia Di RSUD Raden Mattaher Jambi Tahun 2012. Jurnal Penelitian Universitas Jambi Seri Sains. 15(1), 17-26.

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