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Dengue Shock Syndrome Unusual Appearance With Multisystem Inflammatory Syndrome in Children: A Case Report



Abstract

Background: Dengue and coronavirus disease 2019 (COVID-19) have recently become endemic in various tropical countries. Multisystem inflammatory syndrome in children (MIS-C) is a clinical manifestation of COVID-19 with a life-threatening syndrome of hyperinflammation, multiorgan failure, and shock, and it closely resembles the manifestations of severe dengue. Many attempts have been made in research to differentiate the two. Here we aims to describe a case of a patient with dengue coinfection with MIS-C.

Case Presentation: A 17-year-old woman came in a state of shock, with cold extremities, fever, jaundice, shortness of breath, acute abdominal pain, and hematuria, decreased urine output. Further investigations reveal increased parameters of hepato-renal organ damage, c-reactive protein, and anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG). Patient was positive for anti-dengue IgM and IgG, but negative for COVID-19 based on SARS-CoV-2 antigen and polymerase chain reaction.

Conclusion: This case demonstrates the possibility of dengue coinfection and MIS-C co-occurring, causing the patient to develop a hyperinflammatory syndrome and clinical deterioration.

Keywords: COVID-19 Dengue MIS-C Pediatrics

References

  1. Guzman MG, Gubler DJ, Izquierdo A, Martinez E, Halstead SB. Dengue infection. Nat Rev Dis Prim [Internet]. 2016 Dec 22;2(1):16055. Available from: http://www.nature.com/articles/nrdp201655 doi: 10.1038/nrdp.2016.55
  2. Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during the COVID-19 pandemic. Lancet [Internet]. 2020 May;395(10237):1607–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0140673620310941 doi: 10.1016/S0140-6736(20)31094-1
  3. Samprathi M, Narayanappa S, Sridhar M, Ramachandra P, Vemgal P. Multisystem inflammatory syndrome in children: A mimicker of severe dengue. Indian J Pediatr [Internet]. 2021 May 23;88(5):486–7. Available from: https://link.springer.com/10.1007/s12098-020-03550-2 doi: 10.1007/s12098-020-03550-2
  4. Randhawa MS, Angurana SK, Nallasamy K, Kumar M, Ravikumar N, Awasthi P, et al. Comparison of Multisystem Inflammatory Syndrome (MIS-C) and Dengue in Hospitalized Children. Indian J Pediatr [Internet]. 2022 May 5; Available from: http://www.ncbi.nlm.nih.gov/pubmed/35511400 doi: 10.1007/s12098-022-04184-2
  5. Borré-Naranjo D, Cárdenas-Bolívar Y, Manzur-Barbur Maria C, Toro E, Buendía E, Martínez Maria C, et al. Fluid Management in Dengue Critical Phase: Which, When, How Much? Int Arch Med Microbiol [Internet]. 2022 Dec 31;4(1). Available from: https://clinmedjournals.org/articles/iamm/international-archives-of-medical-microbiology-iamm-4-015.php?jid=iamm doi: 10.23937/2643-4008/1710015
  6. World Health Organization. Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19 [Internet]. 2020 [cited 2022 Nov 17]. Available from: https://www.who.int/news-room/commentaries/detail/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19
  7. Randhawa MS, Angurana SK, Nallasamy K, Kumar M, Ravikumar N, Awasthi P, et al. Comparison of Multisystem Inflammatory Syndrome (MIS-C) and Dengue in Hospitalized Children. Indian J Pediatr [Internet]. 2022 May 5; Available from: https://link.springer.com/10.1007/s12098-022-04184-2 doi: 10.1007/s12098-022-04184-2
  8. Samanta J. Dengue and its effects on the liver. World J Clin Cases [Internet]. 2015;3(2):125. Available from: http://www.wjgnet.com/2307-8960/full/v3/i2/125.htm doi: 10.12998/wjcc.v3.i2.125
  9. Cattalini M, Taddio A, Bracaglia C, Cimaz R, Paolera S Della, Filocamo G, et al. Childhood multisystem inflammatory syndrome associated with COVID-19 (MIS-C): a diagnostic and treatment guidance from theRheumatology Study Group of the Italian Society of Pediatrics. Ital J Pediatr [Internet]. 2021 Dec 8;47(1):24. Available from: https://ijponline.biomedcentral.com/articles/10.1186/s13052-021-00980-2 doi: 10.1186/s13052-021-00980-2
  10. Radia T, Williams N, Agrawal P, Harman K, Weale J, Cook J, et al. Multi-system inflammatory syndrome in children & adolescents (MIS-C): A systematic review of clinical features and presentation. Paediatr Respir Rev [Internet]. 2021 Jun;38:51–7. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1526054220301172 doi: 10.1016/j.prrv.2020.08.001
  11. DeBiasi RL. Immunotherapy for MIS-C — IVIG, Glucocorticoids, and Biologics. N Engl J Med [Internet]. 2021 Jul 1;385(1):74–5. Available from: http://www.nejm.org/doi/10.1056/NEJMe2108276 doi: 10.1056/NEJMe2108276.
  12. Koibur JG, Satyarsa AB, Gustawan IW, Putra IG, Utama IM. Lingkungan Tempat Tinggal Sebagai Faktor Resiko Infeksi Virus Dengue Pada Anak-Anak. Indonesian Journal for Health Sciences. 2021;5(1):1-7.
  13. Licciardi F, Baldini L, Dellepiane M, Covizzi C, Mogni R, Pruccoli G, et al. MIS-C Treatment: Is IVIG Always Necessary? Front Pediatr [Internet]. 2021 Nov 3;9. Available from: https://www.frontiersin.org/articles/10.3389/fped.2021.753123/full doi: 10.3389/fped.2021.753123

How to Cite

Rajani, A. A. P. I., Windiyanto, R. ., & Purnama, A. A. R. . (2023). Dengue Shock Syndrome Unusual Appearance With Multisystem Inflammatory Syndrome in Children: A Case Report. Intisari Sains Medis, 14(1), 267–269. https://doi.org/10.15562/ism.v14i1.1618
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Anak Agung Puteri Indira Rajani
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Romy Windiyanto
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Anak Agung Ratna Purnama
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