Rasio perbandingan nilai transepidermal water loss (TEWL) dan power of hydrogen (PH) lesi psoriatic dan non-lesi psoriatic

Putu Gde Hari Wangsa; Ketut Kwartantaya Winaya; I Gusti Ayu Agung Elis Indira; I Gusti Ayu Agung Praharsini; I Gusti Nyoman Darmaputra; Ni Made Dwi Puspawati; Made Wardhana

doi:10.15562/ism.v14i1.1617

Rasio perbandingan nilai transepidermal water loss (TEWL) dan power of hydrogen (PH) lesi psoriatic dan non-lesi psoriatic

Putu Gde Hari Wangsa ,

Ketut Kwartantaya Winaya ,

I Gusti Ayu Agung Elis Indira ,

I Gusti Ayu Agung Praharsini ,

I Gusti Nyoman Darmaputra ,

Ni Made Dwi Puspawati ,

Made Wardhana ,

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DOI: https://doi.org/10.15562/ism.v14i1.1617 |
Published: 2023-01-27

Abstract

Introduction: Psoriasis is a chronic inflammation of the skin. The remission rate of psoriasis is 10-60%, with the risk of depression, skin cancer and suicide. Inflammation leads decrease of skin hydration, and pH, thus it makes destruction of skin barrier. Therefore, this study aimed to determine the function and integrity of the skin barrier as seen from TEWL and pH in psoriatic and non-psoriatic lesions in psoriasis vulgaris patients.

Method: This was a crossectional study, that was conducted in RSUP Prof. Dr. I.G.N.G. Ngoerah, Denpasar around May – July 2022. This study used a consecutive sampling technique, after that the sample was adjusted with the inclusion and exclusion criteria. The data was analyzed by using SPSS version 25. Bivariate analysis used Independent T-Test, for the multivariate analysis used linear regression.

Results: This study obtained 28 samples with the majority was male (60.7%). The average age of the sample was 45.68±15.04. The mean TEWL value in the psoriatic lesion group (24.78 ± 4.77) was higher and the mean pH was lower (5.25 ± 0.18) than the non-psoriatic lesion (TEWL:11.75 ± 2.79; pH 5.63 ± 0.21). TEWL and pH ratio between psoriatic lession and non psoriatic lesion is (TEWL: 2,19 ± 0,11; pH 0,93 ± 0,01). The difference was statistically significant (p<0,01).

Conclusion: There was a significant relationship between an increase in TEWL value and a decrease in pH value in the psoriatic group of lesions compared to the non-psoriatic group.

Latar Belakang : Psoriasis merupakan penyakit inflamasi kronis pada kulit. Psoriasis dilaporkan memiliki tingkat remisi yang tinggi sebesar 10-60%, dengan risiko depresi, kanker kulit, dan bunuh diri. Inflamasi dapat menyebabkan penurunan hidrasi dan PH kulit, sehingga menyebakan kerusakan barrier kulit. Tujuan dari penelitian ini adalah untuk mengetahui fungsi dan integritas barrier kulit dilihat dari TEWL dan pH pada lesi psoriatic dan non-lesi psoriatic pada pasien psoriasis vulgaris.

Metode: Penelitian ini merupakan penelitian potong lintang yang dilakukan di RSUP Prof. Dr. I.G.N.G. Ngoerah, Denpasar, dilakukan pada bulan Mei – Juli 2022. Teknik pengambilan sampel yang digunakan yaitu consecutive sampling dan diseleksi berdasarkan kriteria inklusi dan eksklusi yang telah di tentukan. Data di analisis menggunakan SPSS versi 25. Analisis bivariat menggunakan Independent T-Test, dan analisis multivariat yang digunakan menggunakan regresi linear.

Hasil : Penelitian ini mendapatkan 28 sampel dengan mayoritas berjenis kelamin laki-laki (60,7%). Rata-rata sampel berusia 45,68±15,04. Rerata nilai TEWL pada pada kelompok lesi psoriatic (24,78 ± 4,77) lebih tinggi dan rerata pH lebih rendah (5,25 ± 0,18) dibandingkan non-lesi psoriatic (TEWL:11,75 ± 2,79; pH 5,63 ± 0,21). Rasio TEWL dan pH lesi psoriatic dibandingkan non-lesi psoriatic adalah (TEWL: 2,19 ± 0,11; pH 0,93 ± 0,01). Perbedaan tersebut signifikan secara statistik (p<0,01).

Simpulan: Adapun kesimpulan dari penelitian ini yakni lesi psoriatic secara signifikan memiliki nilai TEWL yang lebih tinggi namun pH yang lebih rendah dengan rasio TEWL sebesar 2,19 ± 0,11 dan rasio pH sebesar 0,93 ± 0,01.

References

Alexander, H., Brown, S., Danby, S. & Flohr, C. Research Techniques Made Simple: Transepidermal Water Loss Measurement as a Research Tool. Journal of Investigative Dermatology, 2018; 138(11): 2295-2300.
Matousek, J.L. & Campbell, K.L. (2002), “A comparative review of cutaneous pH”, Dermatology 2002;13(6): 293–300.
Proksch, E. 2018.pH in nature, humans and skin. Journal of Dermatology 2018; 45(9): 1044–1052.
Montero-Vilchez, T., Segura-Fernández-nogueras, M.V., Pérez-Rodríguez, I., Soler-Gongora, M., Martinez-Lopez, A., Fernández-González, A., Molina-Leyva, A., et al. 2021Skin barrier function in psoriasis and atopic dermatitis: Transepidermal water loss and temperature as useful tools to assess disease severity. Journal of Clinical Medicine 2021:10(2) 1–12.
Lee, Y., Je, Y.J., Lee, S.S., Li, Z.J., Choi, D.K., Kwon, Y. Bin, Sohn, K.C., et al. Changes in transepidermal water loss and skin hydration according to expression of aquaporin-3 in psoriasis. Annals of Dermatology 2012; 24(2): 168–174.
Nikam, V.N., Rochelle, C., Monteiro & Dandakeri, S. Transepidermal Water Loss in Psoriasis : A Case ‑ control Study”, Indian Dermatol Online 2019; 10(1):267–271.
Daniel, E., Blasco, A.J., Bonanad, C., Botella, R., Carrascosa, J.M., González-Parra, E., Jodar, E., et al. Position statement for the management of comorbidities in psoriasis., Journal of the European Academy of Dermatology and Venereology : JEADV 2018; 32 (12):2058–2073.
Bigliardi, P.L. Role of Skin pH in Psoriasis. Current Problems in Dermatology 2018; 54:108–114.

[1] Alexander, H., Brown, S., Danby, S. & Flohr, C. Research Techniques Made Simple: Transepidermal Water Loss Measurement as a Research Tool. Journal of Investigative Dermatology, 2018; 138(11): 2295-2300.

[2] Matousek, J.L. & Campbell, K.L. (2002), “A comparative review of cutaneous pH”, Dermatology 2002;13(6): 293–300.

[3] Proksch, E. 2018.pH in nature, humans and skin. Journal of Dermatology 2018; 45(9): 1044–1052.

[4] Montero-Vilchez, T., Segura-Fernández-nogueras, M.V., Pérez-Rodríguez, I., Soler-Gongora, M., Martinez-Lopez, A., Fernández-González, A., Molina-Leyva, A., et al. 2021Skin barrier function in psoriasis and atopic dermatitis: Transepidermal water loss and temperature as useful tools to assess disease severity. Journal of Clinical Medicine 2021:10(2) 1–12.

[5] Lee, Y., Je, Y.J., Lee, S.S., Li, Z.J., Choi, D.K., Kwon, Y. Bin, Sohn, K.C., et al. Changes in transepidermal water loss and skin hydration according to expression of aquaporin-3 in psoriasis. Annals of Dermatology 2012; 24(2): 168–174.

[6] Nikam, V.N., Rochelle, C., Monteiro & Dandakeri, S. Transepidermal Water Loss in Psoriasis : A Case ‑ control Study”, Indian Dermatol Online 2019; 10(1):267–271.

[7] Daniel, E., Blasco, A.J., Bonanad, C., Botella, R., Carrascosa, J.M., González-Parra, E., Jodar, E., et al. Position statement for the management of comorbidities in psoriasis., Journal of the European Academy of Dermatology and Venereology : JEADV 2018; 32 (12):2058–2073.

[8] Bigliardi, P.L. Role of Skin pH in Psoriasis. Current Problems in Dermatology 2018; 54:108–114.

Rasio perbandingan nilai transepidermal water loss (TEWL) dan power of hydrogen (PH) lesi psoriatic dan non-lesi psoriatic

Abstract

References

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