Skip to main content Skip to main navigation menu Skip to site footer

Profil klinikopatologi karsinoma prostat di Rumah Sakit Umum Pusat Prof. Dr. I.G.N.G. Ngoerah Denpasar periode tahun 2017-2020



Abstract

Background: Prostate cancer or prostate carcinoma is a malignancy that occurs in the cells of the prostate gland and is associated with chronic problems with sexual function, urination, and the patient's psychological well-being. This study was conducted to investigate the clinicopathological profile of prostate cancer patients at Prof dr. I G.N.G. Ngoerah in the period 2017 – 2020.

Methods: This descriptive study used a cross-sectional design conducted at Prof. dr. I G.N.G. Ngoerah Central Hospital. The inclusion criteria were prostate cancer patients in 2017-2020 and the exclusion criteria were patients with incomplete medical record data. The determination of the sample using total sampling with the number of samples that meet the criteria of 82 patients. All statistical analyzes used SPSS ver.25.

Results: Patients in this study had a mean age of 70.89±9.26 years, with the majority aged 50 years and above (97.6%). Most of the patients had the main symptom of urination difficulty (57.5%). PSA levels in patients had a mean of 543.3 ng/mL. Most of the patients had reached stage IV at the time of diagnosis (92.1%). Transurethral resection is the most common specimen retrieval method (47.6%). Almost all samples were diagnosed as acinar adenocarcinoma (95.2%) with the majority categorized into Gleason grade group 5 (64.9%).

Conclusion: Prostate carcinoma cases at Prof. dr. I G.N.G. Ngoerah mostly occurs at the age of >50 years with the main complaint of urination difficulty. The majority of the patients had stage IV with acinar adenocarcinoma histopathological type and Gleason grade group 5.

 

Latar belakang: Kanker prostat atau karsinoma prostat merupakan keganasan yang terjadi pada sel-sel kelenjar prostat yang berkaitan dengan permasalahan kronis terhadap fungsi seksual, berkemih, serta kesejahteraan psikologis pasien. Penelitian ini dilaksanakan dengan tujuan untuk menyelidiki profil klinikopatologi pasien karsinoma prostat di RSUP Prof dr. I  G.N.G. Ngoerah pada periode tahun 2017 – 2020.

Metode: Penelitian ini bersifat deskriptif dengan desain penelitian cross-sectional yang dilakukan di RSUP Prof. dr. I G.N.G. Ngoerah. Kriteria inklusi berupa pasien karsinoma prostat pada tahun 2017-2020 dan kriteria eksklusi berupa pasien dengan data rekam medis yang tidak lengkap. Adapun penentuan sampel menggunakan total sampling dengan jumlah sampel yang memenuhi kriteria sebanyak 82 orang. Seluruh analisis statistik menggunakan SPSS ver.25.

Hasil: Subjek dalam studi ini memiliki mean usia 70,89 ± 9,26 tahun, dengan mayoritas berusia ≥ 50 tahun (97,6%). Sebagian besar pasien mengalami keluhan utama berupa sulit berkemih (57,5%). Kadar PSA pada pasien memiliki mean 543,3 ng/mL. Mayoritas pasien sudah mencapai stadium IV saat terdiagnosis (92,1%). Reseksi transuretral merupakan cara pengambilan sampel dengan frekuensi terbanyak (47,6%). Hampir semua sampel didiagnosis sebagai adenokarsinoma asinar prostat (95,2%) dengan mayoritas Gleason grade group 5 (64,9%).

Simpulan: Kasus karsinoma prostat di RSUP Prof. dr. I G.N.G. Ngoerah sebagian besar terjadi pada usia >50 tahun dengan keluhan utama sulit berkemih. Mayoritas dari pasien menderita stadium IV dengan tipe histopatologi adenokarsinoma asinar dan Gleason grade group 5.

Keywords: Profil klinikopatologi karsinoma prostat

References

  1. Guyton AC, Hall JE. Reproductive and Hormonal Functions of the Male (and Function of the Pineal Gland). In: Guyton and Hall Textbook of Medical Physiology. 13th ed. Philadelphia, Pennsylvania: Elsevier, inc.; 2016. p. 1021–35.
  2. Kementrian Kesehatan Republik Indonesia. Kanker Prostat. Pandu Penatalaksanaan Kanker Prostat. 2015;
  3. Kumar V, Abbas AK, Aster JC. Neoplasia. In: Robbins Basic Pathology. 10th ed. Philadelphia, Pennsylvania: Elsevier inc.; 2018. p. 190–237.
  4. Watson E, Shinkins B, Frith E, Neal D, Hamdy F, Walter F, et al. Symptoms, unmet needs, psychological well-being and health status in survivors of prostate cancer: Implications for redesigning follow-up. BJU Int. 2016; https://doi.org/10.1111/bju.13122
  5. Sharp L, O’Leary E, Kinnear H, Gavin A, Drummond FJ. Cancer-related symptoms predict psychological wellbeing among prostate cancer survivors: Results from the PiCTure study. Psychooncology. 2016; https://doi.org/10.1002/pon.3909
  6. IARC. Globocan 2018 World Report. Glob Cancer Obs. 2019;
  7. World Health Organization. Indonesia Source GLOBOCAN 2018. Int Agency Res Cancer. 2019;
  8. Freeland J, Crowell PD, Giafaglione JM, Boutros PC, Goldstein AS. Aging of the progenitor cells that initiate prostate cancer. Cancer Letters. 2021. https://doi.org/10.1016/j.canlet.2021.05.014
  9. Ulfaningtyas K, Norahmawati E, Anita KW, Angelina A, Seputra KP. Profil Klinikopatologi Adenokarsinoma Prostat Di Rsud Dr. Saiful Anwar Malang Periode Tahun 2015 - 2019: Sebuah Penelitian Retrospektif. Maj Kesehat. 2021; https://doi.org/10.21776/ub.majalahkesehatan.2021.008.02.4
  10. Andreas MI, Alvarino A, Hilbertina N. Gambaran Karsinoma Prostat di RSUP Dr. M. Djamil Padang Tahun 2010-2013. J Kesehat Andalas. 2017; https://doi.org/10.25077/jka.v6i2.696
  11. Oktavia R, Yenita Y. Profil Histopatologik Adenokarsinoma Prostat di Laboratorium Patologi Anatomik Sumatera Barat Tahun 2015-2017. J Kesehat Andalas. 2020; https://doi.org/10.25077/jka.v9i1S.1162
  12. Solang VR, Monoarfa A, Tjandra F. Profil penderita kanker prostat di RSUP Prof. Dr. R. D. Kandou Manado periode tahun 2013–2015. e-CliniC. 2016; https://doi.org/10.35790/ecl.v4i2.14371
  13. Putriyuni A, Hilbertina N. Adenokarsinoma Prostat: Penilaian Prognostik Dan Derajat Histopatologi. Maj Kedokt Andalas. 2015; https://doi.org/10.22338/mka.v37.i2.p93-100.2014
  14. Surveillance, Epidemiology, and End Results Program. In: Definitions. United States Cancer Statistics (USCS); 2020.
  15. Mc Avoy BR, Steginga SK, Pinnock C. The early detection of prostate cancer in general practice: Supporting patient choice. NZJP. 2006;33(1):49–57.
  16. Pepe P, Pennisi M. Gleason score stratification according to age at diagnosis in 1028 men. Wspolczesna Onkol. 2015; https://doi.org/10.5114/wo.2015.56654
  17. Kemp WL, Burns DK, Brown TG. Pathology The big picture. McGraw-Hill’s AccessMedicine. 2008.
  18. Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE. The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours. Eur Urol. 2016; https://doi.org/10.1016/j.eururo.2016.02.028
  19. Lubis AS. Batasan Prostate Specific Antigen (PSA) pada Pasien Kanker Prostat untuk Memprediksi Metastasis ke Tulang di Rumah Sakit Sardjito Yogyakarta. Indones J Cancer. 2014;8:169–72. http://dx.doi.org/10.33371/ijoc.v8i4.362
  20. Hosein I, Sukhraj R, Goetz L, Rambarran N, Persaud S. A Clinicopathological Profile of Prostate Cancer in Trinidad and Tobago. Adv Urol. 2016; https://doi.org/10.1155/2016/2075021
  21. Umbas R, Safriadi F, Mochtar CA, Djatisoesanto W, Hamid ARAH. Urologic cancer in Indonesia. Japanese Journal of Clinical Oncology. 2015. https://doi.org/10.1093/jjco/hyv066
  22. Coard KCM, Skeete DHA. A 6-year analysis of the clinicopathological profile of patients with prostate cancer at the University Hospital of the West Indies, Jamaica. BJU Int. 2009; https://doi.org/10.1111/j.1464-410x.2008.08265.x
  23. Morgan TM, Welty CJ, Vakar-Lopez F, Lin DW, Wright JL. Ductal adenocarcinoma of the prostate: Increased mortality risk and decreased serum prostate specific antigen. J Urol. 2010; https://doi.org/10.1016%2Fj.juro.2010.08.017
  24. Parwani A V., Kronz JD, Genega EM, Gaudin P, Chang S, Epstein JI. Prostate Carcinoma with Squamous Differentiation: An Analysis of 33 Cases. Am J Surg Pathol. 2004; https://doi.org/10.1097/00000478-200405000-00014
  25. Chen R, Ren S, Yiu MK, Fai NC, Cheng WS, Ian LH, et al. Prostate cancer in Asia: A collaborative report. Asian J Urol. 2014; https://doi.org/10.1016/j.ajur.2014.08.007

How to Cite

Louisa, J., I Wayan Juli Sumadi, Herman Saputra, & Ni Putu Ekawati. (2023). Profil klinikopatologi karsinoma prostat di Rumah Sakit Umum Pusat Prof. Dr. I.G.N.G. Ngoerah Denpasar periode tahun 2017-2020. Intisari Sains Medis, 14(1), 118–123. https://doi.org/10.15562/ism.v14i1.1593
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
0

Total
0

Share

Search Panel

Jennifer Louisa
Google Scholar
Pubmed
ISM Journal

I Wayan Juli Sumadi
Google Scholar
Pubmed
ISM Journal

Herman Saputra
Google Scholar
Pubmed
ISM Journal

Ni Putu Ekawati
Google Scholar
Pubmed
ISM Journal