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Hubungan tingkat keparahan stenosis aorta terkait penyakit jantung rematik dengan usia

Abstract

Introduction: The prevalence of Rheumatic heart disease (RHD) was reported to reach 30 million cases worldwide with mortality up to 305,000 people each year. RHD can be accompanied by rheumatic aortic stenosis which is a narrowing of the aortic valve of the heart. Recent studies have shown that increasing age is associated with worsening of the stenosis condition caused by several mechanisms including the calcification process and cytokine dysregulation, but related research is still limited in Indonesia. This study aims to determine the correlation between the severity of aortic stenosis related to rheumatic heart disease and age at Prof. RSUP. Dr. I.G.N.G Ngoerah, Denpasar, Bali.

Method: This cross-sectional study was conducted on the population of patients with rheumatic aortic stenosis at Prof. RSUP. Dr. I.G.N.G Ngoerah. Data collection was carried out using medical records of 2018-2022 period. All data processing was carried out using the SPSS ver. 26.

Result: A total of 34 patients with rheumatic aortic stenosis were collected to be mostly <60 years old, 29 patients (85,3%) with the mean age of all patients was 48 ± 14.5 years. As many as 19 patients (55.9%) had severe, 10 patients (29.4%) had moderate, and 5 patients (14.7%) had mild stenosis severity. Bivariate analysis showed there was a significant correlation between age and severity of stenosis (r=0.501; p=0.003).

Conclusion: Therefore, this study concluded that there was a significant correlation between the severity of stenosis and age in patients with rheumatic aortic stenosis at Prof. RSUP. Dr. I.G.N.G Ngoerah.

 

Pendahuluan: Prevalensi Rheumatic heart disease (RHD) dilaporkan mencapai 30 juta kasus di seluruh dunia serta menjadi penyebab kematian sebanyak 305 ribu jiwa tiap tahunnya. RHD dapat disertai dengan rheumatic aortic stenosis yang merupakan penyempitan katup aorta jantung. Studi terbaru menunjukkan bahwa peningkatan usia berkaitan dengan perburukan kondisi stenosis yang disebabkan oleh beberapa mekanisme termasuk proses kalsifikasi dan disregulasi sitokin, namun penelitian terkait masih terbatas di Indonesia. Penelitian ini bertujuan untuk mengetahui hubungan tingkat keparahan stenosis aorta terkait penyakit jantung rematik dengan usia di RSUP Prof. Dr. I.G.N.G Ngoerah, Denpasar, Bali.

Metode: Penelitian ini merupakan studi observasional dengan desain potong lintang dengan teknik pengumpulan data menggunakan total sampling pada populasi pasien rheumatic aortic stenosis di di RSUP Prof. Dr. I.G.N.G Ngoerah. Pengumpulan data dilakukan dengan rekam medis periode 2018-2022. Pengolahan data dilakukan menggunakan aplikasi SPSS ver.26 dengan analisis univariat dan bivariat (Uji Spearm`an’s Rho).

Hasil: Sebanyak 34 pasien rheumatic aortic stenosis diperoleh dengan sebagian besar berusia <60 tahun, yakni sebanyak 29 pasien (85,3%) dengan rerata usia seluruh pasien adalah 46,4 ± 14,7 tahun. Adapun sebanyak 19 orang (55,9%) memiliki tingkat keparahan berat (severe), 10 orang (29,4%) dengan keparahan sedang (moderate), dan 5 orang (14,7%) dengan keparahan ringan (mild). Analisis bivariat menunjukkan terdapat hubungan yang signifikan antara usia dengan tingkat keparahan stenosis pada pasien rheumatic aortic stenosis (r=0,501; p=0,003).

Conclusion: Terdapat hubungan yang signifikan antara tingkat keparahan stenosis dengan usia pada pasien rheumatic aortic stenosis di RSUP Prof. Dr. I.G.N.G Ngoerah.

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How to Cite

Kosasih, R. A., Suastika, L. O. S., Sinardja, C. W. D., & Artana, I. G. N. B. (2023). Hubungan tingkat keparahan stenosis aorta terkait penyakit jantung rematik dengan usia. Intisari Sains Medis, 14(1), 53–58. https://doi.org/10.15562/ism.v14i1.1574

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Rogerio Andrez Kosasih
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Luh Oliva Saraswati Suastika
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Cyndiana Widia Dewi Sinardja
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I Gusti Ngurah Bagus Artana
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