Skip to main content Skip to main navigation menu Skip to site footer

Profil pasien COVID-19 rawat inap di Rumah Sakit Ari Canti, Gianyar, Bali, Indonesia

Abstract

Background: Since March 2020, Coronavirus Disease 2019 (COVID-19) has been declared a pandemic. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) underwent genetic evolution and changes in the nature of the virus, clinical manifestations, and response to treatment. This study aims to determine the profile of hospitalized COVID-19 patients at  Ari Canti Hospital (RSAC), one of the COVID-19 referral hospitals in Gianyar, Bali.

Methods: The design was a descriptive cross-sectional retrospective study, using the medical records of confirmed COVID-19 by Real Time Polymerase Chain Reaction (RT-PCR) patients selected by a simple random sampling technique.

Results: From 290 samples, the majority of COVID-19 patients treated at RSAC were 60.7% male, in the age range of 50-59 years 26.5%, with severe symptoms 45.8% and recovered 83.4%. The dominant symptoms were fever 85.2%, cough 80%, and shortness of breath 60%. The most common comorbidities were >1 comorbidity, hypertension, and diabetes mellitus. Hematological examination at the first time of hospitalization showed leukopenia (4.8%), lymphopenia (14.5%), thrombocytopenia (12.8%),  and anemia (21.7%). The results also showed an increase in Neutrophil to Lymphocyte ratio (NLR) (31.4%), Platelet to lymphocyte ratio (PLR) (11.7%), Red Cell Distribution Width (RDW) (40.7%), D-Dimer  (73.4% ) dan High sensivity C-Reactive Protein (Hs-CRP)  (66.6%). Most showed bilateral infiltrates on chest x-ray. The most common treatment for COVID-19 at RSAC uses antiviral remdesivir (77.9%), quinolone antibiotics (73.4%), and Low Molecular Weight Heparin (LMWH) (53.4%).  A total of 56.6% of patients received corticosteroid therapy.

Conclusion: Patients hospitalized at RSAC mostly showed severe symptoms and recovered. The treament folowing the standard of inpatient treatment for COVID-19 patients.

 

Latar belakang: Sejak Maret 2020, Coronavirus Disease 2019 (COVID 19) dinyatakan sebagai pandemi. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mengalami evolusi genetik dan perubahan sifat virus, manifestasi klinis serta respon pengobatan. Penelitian ini bertujuan untuk mengetahui profil pasien COVID-19 yang dirawat di Rumah Sakit Ari Canti (RSAC), salah satu rumah sakit rujukan COVID-19 di Gianyar, Bali

Metode: Rancangan penelitian ini adalah cross-sectional deskriptif retrospektif, menggunakan rekam medis pasien terkonfirmasi COVID-19 dengan Real Time Polymerase Chain Reaction (RT-PCR) sejak Juli 2020 - Maret 2022 yang dipilih dengan teknik simple random sampling.

Hasil: Dari 290 sampel, mayoritas pasien COVID-19 yang dirawat di RSAC adalah laki-laki 60.7%, berada pada rentang usia 50-59 tahun 26.5%, dengan gejala berat 45.8% dan sembuh 83.4%. Gejala didominasi demam 85.2%, batuk 80%, dan sesak 60%. Komorbid tersering yaitu >1 komorbid, hipertensi, dan diabetes melitus. Gambaran hematologi menunjukkan leukopenia (4.8%), limfopenia (14.5%), trombositopenia (12.8%), dan  anemia (21.7%). Hasil juga menunjukkan peningkatan Neutrophil to Lymphocyte ratio (NLR) (31.4%), Platelet to lymphocyte ratio (PLR) (11.7%), Red Cell Distribution Width (RDW) (40.7%), D-Dimer (73.4% ) dan High sensivity C-Reactive Protein (Hs-CRP) (66.6%). Sebagian besar menunjukkan infiltrat bilateral pada x-ray thorax. Tatalaksana COVID-19 di RSAC tersering menggunakan antivirus remdesivir (77.9%), antibiotik golongan kuinolon (73.4%), dan antikoagulan Low Molecule Weight Heparin (LMWH) (53.4%). Sebanyak 56.6 % pasien mendapat terapi kortikosteroid.

Kesimpulan: Pasien COVID-19 yang dirawat di RSAC sebagian besar menunjukkan gejala berat dan sembuh. Terapi yang diberikan mengikuti standar terapi rawat inap pasien COVID-19.

References

  1. Prabawa IMY, Silakarma D, Prabawa IPY, Manuaba IBAP. Physical Rehabilitation Therapy for Long COVID-19 Patient with Respiratory Sequelae: A Systematic Review. Open Access Maced J Med Sci. 2022;10(F):468-74.
  2. Herawati S, Kandarini Y, Mulyantari NK, Prabawa IPY. Correlation of Neutrophil to Lymphocyte Ratio with Interleukin-10 in Diagnosis and Monitoring of Coronavirus Disease-19 Patients. Open Access Maced J Med Sci. 2022;10(B):63-6.
  3. Elisabetta C, John EB, Laura ER. Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift. Nature 2022;602;664-670.
  4. Parwanto MLE, Digambiro RA, Nusantara DU, Rarasati T. Coronavirus disease 2019 (COVID-19): A case report in a patient with diabetic ketoacidosis and hypertension. Bali Medical Journal. 2020;9(3):624-629.
  5. Beyerstedt S, Casarol EB, Rangel EB. COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. Eur J Clin Microbiol Infect Dis. 2021;40:905–919.
  6. Hsieh PP, Kristian H, Permana AJM, Wongsodiharjo M, Nugraheni PA, Charisti P, Diarsvitri W. The clinical pictures of COVID-19 pediatric patients in dr. R. Soedarsono Regional General Hospital, Pasuruan, East Java, Indonesia. Bali Medical Journal. 2022;11(1):460-465.
  7. Henry BM, Benoit JL, Benoit S, Pulvino C, Berger BA, de Olivera MHS. Red Blood Cell Distribution Width (RDW) Predicts COVID-19 Severity: A Prospective, Observational Study From the Cincinnati SARS- CoV-2 Emergency Department Cohort. Diagnostics. 2020;10(9):1–9.
  8. Nurhidayati T, Sari SR, Soesanto E, Setyawati D. The Influence of health education about covid-19 on posbindu participants’ knowledge levels at Puskesmas Gesi. Bali Medical Journal 2021;10(3):1216-1219.
  9. Indra B, Lipoeto NI, Hardisman H, Putra AE, Tjong DH, Rahman S, Yusri E, Bilhaq MR, Pratama Y, Risman Y. The Severity of COVID-19 and its Correlation with Inflammation Biomarkers. Open Access Maced J Med Sci. 2022;10(A):911-5.
  10. Langford B, So M, Raybardhan S, Leung V, Soucy JR, Westwood D. Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis. Clinical Microbiology and Infection. 2021;27:520-531.
  11. Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L. Dexamethasone in hospitalized patients with Covid-19. N Engl J Med. 2021;384(8):693-704.
  12. Huang Y, Tu M, Wang S, Chen S, Zhou W, Chen D. Clinical Characteristics Of Laboratory Confirmed Positive Cases Of SARS-CoV-2 Infection In Wuhan, China: A Retrospective Single Center Analysis. Travel Med Infect Dis. 2020;36:1–3.
  13. Lopes RD, Macedo AVS, Silva PD, Moll-Bernardes RJ, Santos TM, Mazza L. Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19 A Randomized Clinical Trial. JAMA. 2021;325( 3):254-264.
  14. Zou X, Chen K, Zou J, Han P, Hao J, Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019- nCoV infection. Frontiers of Medicine. 2021;14:185–192.
  15. Peng J, Qi1 D, Yuan G, Deng X, Mei Y, Feng L. Diagnostic value of peripheral hematologic markers for coronavirus disease 2019 (COVID-19): A multicenter, crosssectional Study. J Clin Lab Anal. 2020;34:e23475
  16. Liu Y, Sun W, Guo Y, Chen L, Zhang L, Zhao S. Association Between Platelet Parameters And Mortality In Coronavirus Disease 2019: Retrospective Cohort Study. Platelets. 2020;31(4):490–6.
  17. Nugrahaningsih DAA, Purnomo E, Siswanto, Reviono, Yasmina A, Prenggono MD, Fajari NM, Rudiansyah M, Harsini, Syarif RA, Sholikah, EN. Features of COVID-19 adult patients and the treatment in Indonesia: a retrospective cohort study. Bali Medical Journal. 2022;11(1):528-539.
  18. Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L. Dexamethasone in hospitalized patients with Covid-19. N Engl J Med. 2021; 384(8):693-704.
  19. Ranjbar K, Moghadami M, Mirahmadizadeh A, Fallahi MJ, Shahriarirad KVR, Erfani A. Methylprednisolone or dexamethasone, which one is superior corticosteroid in the treatment of hospitalized COVID-19 patients: a triple-blinded randomized controlled trial. BMC Infectious Diseases. 2021;21:337.
  20. Surendraa H, Elyazara IRF, Djaafaraa BA, Ekawatia LL, Saraswatia K, Adrian V. Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study. The Lancet Regional Health Western Pacific. 2021;9:100-108.

How to Cite

Wiryandari, N. P. N., & Suardamana, K. (2022). Profil pasien COVID-19 rawat inap di Rumah Sakit Ari Canti, Gianyar, Bali, Indonesia. Intisari Sains Medis, 13(3), 684–689. https://doi.org/10.15562/ism.v13i3.1497

HTML
0

Total
0

Share

Search Panel

Ni Putu Nita Wiryandari
Google Scholar
Pubmed
ISM Journal


Ketut Suardamana
Google Scholar
Pubmed
ISM Journal