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Comparison of mortality and severity in Coronavirus disease 2019 (COVID-19) patient with and without diabetes mellitus: a systematic review

Abstract

Background. Coronavirus disease-19 (COVID-19) has been a global pandemic since it was first discovered in Wuhan, China, on December 2019. Several studies found that comorbidity in COVID-19 patients, such as diabetes mellitus is a risk factor for mortality and more severe infection in COVID-19 patients. This systematic review aims to review the comparison of mortality and severity in COVID-19 patients with and without DM.

Method. This systematic review was performed in line with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) diagram Google Scholar, PubMed, and Europe PMC as electronic database sources. We used a checklist from Joanna Briggs Institute for cross sectional, cohort, and case-control studies for quality assessment.

Result. We included 24 studies in this systematic review, consisting of 19 cohort studies, three cross sectional studies, and two case-control studies. All studies included were classified as good studies by study quality assessment. Most study samples are male patients with an average age of more than 50. All studies found a higher mortality rate and severe infection in COVID-19 patients in the DM group compared with the non-DM group. COVID-19 patients in the DM group have a 7.67 higher mortality risk compared with the non-DM group. While for the severity, COVID-19 patients in the DM group have a 6.07 greater risk for severe infection than the non-DM group.

Conclusion. There is a higher mortality rate and more severe infection in COVID-19 patients in the DM group compared with the non-DM group.

References

  1. World Health Organization (WHO). Coronavirus disease (COVID-19) pandemic. Accessed on: 20th August 2022. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019.
  2. Worldometer, Coronavirus Cases. COVID-19 Coronavirus Pandemic. Accessed on: 20th August 2022. Available at: https://www.worldometers.info/coronavirus/coronavirus-cases/#total-cases.
  3. Worldometer, Coronavirus Cases. COVID-19 Coronavirus Pandemic. Accessed on: 20th August 2022. Available at: https://www.worldometers.info/coronavirus/country/indonesia/
  4. Lim ZJ, Subramaniam A, Ponnapa Reddy M, Blecher G, Kadam U, Afroz A, Rubulotta F. Case fatality rates for patients with COVID-19 requiring invasive mechanical ventilation. A meta-analysis. American journal of respiratory and critical care medicine. 2021; 203(1): 54-66. DOI: 10.1164/rccm.202006-2405OC
  5. Sharma P, Behl T, Sharma N, Singh S, Grewal AS, Albarrati A, Bungau S. COVID-19 and diabetes: Association intensify risk factors for morbidity and mortality. Biomedicine & Pharmacotherapy. 2022: 113089. https://doi.org/10.1016/j.biopha.2022.113089
  6. Kumar A, Arora A, Sharma P, Anikhindi SA, Bansal N, Singla V, Srivastava A. Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020; 14(4): 535-545. https://doi.org/10.1016/j.dsx.2020.04.044
  7. Petrakis V, Panagopoulos P, Papazoglou D, Papanas N. Diabetes mellitus and hypertension as major risk factors of mortality from Covid-19 pneumonia. Experimental and Clinical Endocrinology & Diabetes. 2022; 130(03): 205-206. DOI 10.1055/a-1325-0381
  8. Aggarwal G, Lippi G, Lavie CJ, Henry BM, Sanchis‐Gomar F. Diabetes mellitus association with coronavirus disease 2019 (COVID‐19) severity and mortality: a pooled analysis. Journal of diabetes. 2020; 12(11): 851. DOI: 10.1111/1753-0407.13091
  9. World Health Organization (WHO). Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). Accessed on: 20th August 2022. Available at: https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf
  10. Gomes C. Report of the WHO-China joint mission on coronavirus disease 2019 (COVID-19). Brazilian Journal of Implantology and Health Sciences. 2020; 2(3).
  11. Joanna Briggs Institute (JBI). JBI Critical Appraisal Checklist for Analytical Cross Sectional Studies. Accessed on: 22nd August 2022. Available at: https://jbi.global/sites/default/files/2019-05/JBI_Critical_Appraisal-Checklist_for_Analytical_Cross_Sectional_Studies2017_0.pdf
  12. Joanna Briggs Institute (JBI). JBI Critical Appraisal Checklist for Cohort Studies. Accessed on: 22nd August 2022. Available at: https://jbi.global/sites/default/files/2019-05/JBI_Critical_Appraisal-Checklist_for_Cohort_Studies2017_0.pdf.
  13. Joanna Briggs Institute (JBI). JBI Critical Appraisal Checklist for Case-Control Studies. Accessed on: 22nd August 2022. Available at: https://jbi.global/sites/default/files/2019-05/JBI_Critical_Appraisal-Checklist_for_Case_Control_Studies2017_0.pdf
  14. Alkundi A, Mahmoud I, Musa A, Naveed S, Alshawwaf M. Clinical characteristics and outcomes of COVID-19 hospitalized patients with diabetes in the United Kingdom: a retrospective single center study. Diabetes Research and Clinical Practice. 2020; 165: 108263. DOI: https://doi.org/10.1016/j.diabres.2020.108263
  15. Alshukry A, Abbas MB, Ali Y, Alahmad B, Al-Shammari AA, Alhamar G, Ali H. Clinical characteristics and outcomes of COVID-19 patients with diabetes mellitus in Kuwait. Heliyon. 2021; 7(4): e06706. DOI: https://doi.org/10.1016/j.heliyon.2021.e06706
  16. Badedi M, Muhajir A, Alnami A, Darraj H, Alamoudi A, Agdi Y, Ageeb A. The severity and clinical characteristics of COVID-19 among patients with type 2 diabetes mellitus in Jazan, Saudi Arabia. Medicine. 2022; 101(18): e29215. http://dx.doi.org/10.1097/MD.0000000000029215
  17. Yusupova, A, Faizova R, Yurkovskaya O, Belyaeva T, Terekhova T, Khismetova A, Glushkova N. Clinical characteristics and risk factors for disease severity and mortality of COVID-19 patients with diabetes mellitus in Kazakhstan: A nationwide study. Heliyon. 2021; 7(3): e06561. https://doi.org/10.1016/j.heliyon.2021.e06561
  18. Fox T, Ruddiman K, Lo KB, Peterson E, DeJoy R, Salacup G, Patarroyo-Aponte G. The relationship between diabetes and clinical outcomes in COVID-19: a single-center retrospective analysis. Acta Diabetologia. 2021; 58(1): 33-38. https://doi.org/10.1016/j.heliyon.2021.e06561
  19. Fu L, Fei J, Xiang HX, Xiang Y, Tan ZX, Li MD, Xu DX. Analysis of death risk factors among 200 COVID-19 patients in Wuhan, China: a hospital-based case-cohort study. Fang-Fang and Liu, Hong-Yan and Zheng, Ling and Li, Ying and Zhao, Hui and Xu, De-Xiang, Analysis of Death Risk Factors Among. 2020; 200: p1-25. http://dx.doi.org/10.2139/ssrn.3551430
  20. Guo W, Li M, Dong Y, Zhou H, Zhang Z, Tian C, Hu D. Diabetes is a risk factor for the progression and prognosis of COVID‐19. Diabetes/metabolism research and reviews. 2020; 36(7): e3319. DOI: 10.1002/dmrr.3319
  21. Harbuwono DS, Handayani DO, Wahyuningsih ES, Supraptowati N, Kurniawan F, Wafa S, Tahapary DL. Impact of diabetes mellitus on COVID-19 clinical symptoms and mortality: Jakarta’s COVID-19 epidemiological registry. Primary Care Diabetes. 2022; 16(1): 65-68. https://doi.org/10.1016/j.pcd.2021.11.002
  22. Hui Y, Li Y, Tong X, Wang Z, Mao X, Huang L, Zhang D. The risk factors for mortality of diabetic patients with severe COVID-19: a retrospective study of 167 severe COVID-19 cases in Wuhan. PLoS One. 2020; 15(12): e0243602. https://doi.org/10.1371/journal.pone.0243602
  23. Khalili S, Moradi O, Kharazmi AB, Raoufi M, Sistanizad M, Shariat M. Comparison of mortality rate and severity of pulmonary involvement in coronavirus Disease-2019 adult patients with and without type 2 diabetes: a cohort study. Canadian Journal of Diabetes. 2021; 45(6): 524-530. https://doi.org/10.1016/j.jcjd.2020.10.014
  24. Liu Z, Li J, Huang J, Guo L, Gao R, Luo K, Wu X. Association between diabetes and COVID-19: a retrospective observational study with a large sample of 1,880 cases in Leishenshan Hospital, Wuhan. Frontiers in endocrinology. 2020; 11: 478. doi: 10.3389/fendo.2020.00478
  25. Liu Y, Lu R, Wang J, Cheng Q, Zhang R, Zhang S, Hong T. Diabetes, even newly defined by HbA1c testing, is associated with an increased risk of in-hospital death in adults with COVID-19. BMC Endocrine Disorders. 2021; 21(1): 1-10. https://doi.org/10.1186/s12902-021-00717-6
  26. Mirsoleymani S, Taherifard E, Taghrir MH, Marzaleh MA, Peyravi M, Nekooghadam SM. Predictors of mortality among covid-19 patients with or without comorbid diabetes mellitus. Acta Medica Iranica. 2021; 393-399. https://doi.org/10.18502/acta.v59i7.7018
  27. Mithal A, Jevalikar G, Sharma R, Singh A, Farooqui KJ, Mahendru S, Budhiraja S. High prevalence of diabetes and other comorbidities in hospitalized patients with COVID-19 in Delhi, India, and their association with outcomes. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2021; 15(1): 169-175. DOI: 10.20473/jbe.v10i22022.219–226
  28. Moftakhar L, Moftakhar P, Pirate E, Ghaem H, Valipour A, Azarbakhsh H. Epidemiological characteristics and outcomes of COVID-19 in diabetic versus non-diabetic patients. International journal of diabetes in developing countries. 2021; 41(3): 383-388. https://doi.org/10.1007/s13410-021-00930-y
  29. Mokoagow MI, Harbuwono DS, Kshanti IA, Romande CM, Subekti I, Harimurti K, Shatri H. Increased Risk of Poor Clinical Outcome in COVID-19 Patients with Diabetes Mellitus and in-hospital Mortality Predictors: A Retrospective Cohort from a Tertiary Hospital in Indonesia. medRxiv. 2021; 2021-12. doi: https://doi.org/10.1101/2021.12.30.21266217
  30. Nadzifah YN, Hidajah AC. The Relationship of Diabetes Mellitus and Hypertension with Mortality in Covid-19 Patients. Jurnal Berkala Epidemiologi. 2022; 10(2): 219-226. DOI: 10.20473/jbe.v10i22022.219–226
  31. Orioli L, Servais T, Belkhir, L, Laterre PF, Thissen, JP, Vandeleene B, Hermans MP. Clinical characteristics and short-term prognosis of in-patients with diabetes and COVID-19: a retrospective study from an academic center in Belgium. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2021; 15(1): 149-157. https://doi.org/10.1016/j.dsx.2020.12.020
  32. Satman I, Demirci I, Hayman C, Tasci I, Salman S, Ata N, Sonmez A. Unexpectedly lower mortality rates in COVID-19 patients with and without type 2 diabetes in Istanbul. diabetes research and clinical practice. 2021; 174: 108753. https://doi.org/10.1016/j.dsx.2020.12.020
  33. Silverii GA, Monami M, Cernigliaro A, Vigneri E, Guarnotta V, Scondotto S, Mannucci E. Are diabetes and its medications risk factors for the development of COVID-19? Data from a population-based study in Sicily. Nutrition, Metabolism and Cardiovascular Diseases. 2021; 31(2): 396-398. https://doi.org/10.1016/j.numecd.2020.09.028
  34. Soliman A, Nair AP, Al Masalamani MS, De Sanctis V, Khattab MAA, Alsaud AE, Yassin M. Prevalence, clinical manifestations, and biochemical data of type 2 diabetes mellitus versus nondiabetic symptomatic patients with COVID-19: A comparative study. Acta Bio Medica: Atenei Parmensis. 2020; 91(3): e2020010. DOI: 10.23750/ABM.v91i3.10214
  35. Wulandari EW, Rotnoatmodjo S, Salama N. Diabetes Mellitus and Mortality among COVID-19 Patients in Jakarta, March-August 2020. Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal). 2022; 17(2). DOI: 10.21109/kesmas.v17i2.5815
  36. Zakerkish M, Fooladi MS, Shahbazian HB, Ahmadi F, Payami SP, Dargahi-Malamir M. Assessment of mortality rate, need for ICU admission and ventilation in COVID-19 patients with diabetes mellitus. Qatar Medical Journal. 2022; (1): 9. http://doi.org/10.5339/qmj.2022.9
  37. Zhang Y, Cui Y, Shen M, Zhang J, Liu B, Dai M, Pan P. Association of diabetes mellitus with disease severity and prognosis in COVID-19: a retrospective cohort study. Diabetes research and clinical practice. 2020; 165: 108227. https://doi.org/10.1016/j.diabres.2020.108227
  38. Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, Duan G. Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses. 2020; 12(4): 372. doi:10.3390/v12040372
  39. Cao W, Taisheng L. COVID-19: towards understanding of pathogenesis. Cell research. 2020: 367-369. https://doi.org/10.1038/s41422-020-0327-4

How to Cite

Poerniawan, C. (2023). Comparison of mortality and severity in Coronavirus disease 2019 (COVID-19) patient with and without diabetes mellitus: a systematic review. Intisari Sains Medis, 14(1), 14–20. https://doi.org/10.15562/ism.v14i1.1496

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Christian Poerniawan
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