Skip to main content Skip to main navigation menu Skip to site footer

Efektivitas vaksin influenza terhadap kejadian rawat inap pada anak dengan influenza: sebuah tinjauan sistematik dan meta analisis



Abstract

Background: Influenza is a respiratory infection that is often experienced by children. Influenza particularly happens in developing countries with a high number of cases. Global influence on influenza vaccine research has now been carried out to reduce the incidence of inpatient and severe influenza complications.
Objective: To examine the effectiveness of the influenza vaccine (EVI) on inpatient events related to influenza disease in children.
Methods: Search for published scientific articles using the prism method (preferred reporting, items for systematic reviews and meta-analysis). The search was carried out on a PubMed database, Cochrane Library and Medline published in the last 10 years until 1st May 2022, about influenza vaccines on inpatient events related to influenza in children. All types of studies are included if the result is inpatient, respondents under the age of 18 and influenza infections are confirmed for the laboratory results. All analyses in our research were conducted using STATA V13.1 (Stata Corporation, College Station, TX)
Results: A randomized meta-analysis of 34 studies that use seasonal cohort and cross-sectional designs assesses the effectiveness of influenza vaccine (EVI) on inpatient events in children by 52.6% (95% CI: 50.9 -54,2) for all influenza. It was found that EVI was higher in influenza A/H1N1PDM09 at 70.0% (95%CI: 66.3-73.6) compared to Influenza A/H3n2 (38.9%; 95%CI: 31.8-46.1) and influenza B (46.7%; 95%CI: 41.9-51.4). According to the type of vaccine, EVI is obtained in the higher QIV type, which is 60.4% (95% CI: 55.3-65.5) compared to other types of vaccines.
Conclusion: Based on the results of this meta-analysis reinforces evidence that shows that influenza vaccination is generally an effective action to prevent inpatient events related to influenza in children.

 

Latar belakang: Penyakit influenza merupakan salah satu penyakit infeksi pernapasan yang sering dialami anak-anak. Influenza khususnya terjadi negara berkembang dengan kondisi jumlah kasus yang masih tinggi. Untuk menurunkan kejadian rawat inap dan komplikasi penyakit infuenza yang berat, saat ini telah dilakukan penelitian vaksin influenza secara global.
Tujuan: Untuk menelaah efektivitas vaksin influenza (EVI) terhadap kejadian rawat inap terkait penyakit influenza pada anak-anak.
Metode: Penelusuran artikel-artikel ilmiah terpublikasi menggunakan metode PRISMA (Preferred Reporting, Items for Systematic Reviews and Meta Analysis). Pencarian dilakukan dengan basis data PubMed, Cochrane library dan Medline yang diterbitkan pada 10 tahun terakhir hingga bulan Mei 2022, tentang vaksin influenza terhadap kejadian rawat inap terkait penyakit influenza pada anak-anak. Semua jenis studi dimasukkan jika hasilnya adalah rawat inap, responden yang berumur di bawah 18 tahun dan infeksi influenza dikonfirmasi atas hasil laboratorium. Semua analisis dalam penelitian kami dilakukan dengan menggunakan Stata v13.1 (Stata Corporation, College Station, TX)
Hasil: Sebuah meta-analisis efek acak dari 34 studi yang menggunakan desain cohort dan cross-sectional musiman yang dikumpulkan menilai efektivitas vaksin influenza (EVI) terhadap kejadian rawat inap pada anak-anak sebesar 52,6% (95%CI: 50,9-54,2) untuk semua influenza. Diperoleh bahwa EVI lebih tinggi terhadap influenza A/H1N1pdm09 sebesar 70,0% (95%CI: 66,3-73,6) dibandingkan influenza A/H3N2 (38,9%; 95%CI: 31,8-46,1) dan influenza B (46,7%; 95%CI: 41,9-51,4). Berdasarkan jenis vaksin, diperoleh EVI pada jenis QIV lebih tinggi yaitu sebesar 60,4% (95%CI: 55,3-65,5) dibandingkan dengan jenis vaksin lainnya.
Simpulan: Berdasarkan hasil meta-analisis ini menguatkan bukti yang menunjukkan bahwa vaksinasi influenza umumnya adalah tindakan efektif untuk mencegah kejadian rawat inap terkait penyakit influenza pada anak-anak.

Keywords: Efektivitas vaksin influenza anak-anak rawat inap meta-analisis

References

  1. Kumar V. Influenza in Children. Indian J Pediatr [Internet]. 2017;84(2):139–43. Available from: http://dx.doi.org/10.1007/s12098-016-2232-x
  2. Tran D, Vaudry W, Moore D, Bettinger JA, Halperin SA, Scheifele DW, et al. Hospitalization for influenza A versus B. Pediatrics. 2016;138(3).
  3. Kalligeros M, Shehadeh F, Mylona EK, Dapaah-Afriyie C, Aalst R van, Chit A, et al. Influenza vaccine effectiveness against influenza-associated hospitalization in children: A systematic review and meta-analysis. Vaccine. 2020;38(14):2893–903.
  4. Jackson ML. Evaluation of influenza vaccine effectiveness. World Health Organization, editor. World Health Organization; 2017. 1–47 p.
  5. Boddington NL, Warburton F, Zhao H, Andrews N, Ellis J, Donati M, et al. Influenza vaccine effectiveness against hospitalisation due to laboratory-confirmed influenza in children in England in the 2015–2016 influenza season – A test-negative case–control study. Epidemiol Infect. 2019;147.
  6. Bissielo A, Pierse N, Huang Q, Thompson M, Kelly H, Mishin V, et al. Effectiveness of seasonal influenza vaccine in preventing influenza primary care visits and hospitalisation in Auckland, New Zealand in 2015: Interim estimates. Eurosurveillance [Internet]. 2016;21(1):1–5. Available from: http://dx.doi.org/10.2807/1560-7917.ES.2016.21.1.30101
  7. Sofia Arriola C, El Omeiri N, Azziz-Baumgartner E, Thompson MG, Sotomayor-Proschle V, Fasce RA, et al. Influenza vaccine effectiveness against hospitalizations in children and older adults—Data from South America, 2013–2017. A test negative design. Vaccine X. 2019;3.
  8. Stein Y, Mandelboim M, Sefty H, Pando R, Mendelson E, Shohat T, et al. Seasonal Influenza Vaccine Effectiveness in Preventing Laboratory-Confirmed Influenza in Primary Care in Israel, 2016-2017 Season: Insights Into Novel Age-Specific Analysis. Clin Infect Dis. 2018;66(9):1383–91.
  9. Norman DA, Cheng AC, Macartney KK, Moore HC, Danchin M, Seale H, et al. Influenza hospitalizations in Australian children 2010–2019: The impact of medical comorbidities on outcomes, vaccine coverage, and effectiveness. Influenza Other Respi Viruses. 2022;16(2):316–27.
  10. Pebody RG, Zhao H, Whitaker HJ, Ellis J, Donati M, Zambon M, et al. Effectiveness of influenza vaccine in children in preventing influenza associated hospitalisation, 2018/19, England. Vol. 38, Vaccine. 2020. p. 158–64.
  11. Chiu SS, Kwan MYW, Feng S, Chan ELY, Chua H, Wong JSC, et al. Early season estimate of influenza vaccination effectiveness against influenza hospitalisation in children, Hong Kong, winter influenza season 2018/19. Eurosurveillance [Internet]. 2019;24(5):2–5. Available from: http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1900056
  12. Caspard H, Mallory RM, Yu J, Ambrose CS. Live-Attenuated Influenza Vaccine Effectiveness in Children From 2009 to 2015–2016: A Systematic Review and Meta-Analysis. Open Forum Infect Dis. 2017;4(3):1–9.
  13. Block SL, Falloon J, Hirschfield JA, Krilov LR, Dubovsky F, Yi T, et al. Immunogenicity and safety of a quadrivalent live attenuated influenza vaccine in children. Pediatr Infect Dis J. 2012;31(7):745–51.
  14. Poehling KA, Caspard H, Peters TR, Belongia EA, Congeni B, Gaglani M, et al. 2015-2016 vaccine effectiveness of live attenuated and inactivated influenza vaccines in children in the United States. Clin Infect Dis. 2018;66(5):665–72.
  15. Pebody R, McMenamin J, Nohynek H. Live attenuated influenza vaccine (LAIV): recent effectiveness results from the USA and implications for LAIV programmes elsewhere. Arch Dis Child Educ Pr Ed. 2017;0:1–5.
  16. Caspard H, Gaglani M, Clipper L, Belongia EA, McLean HQ, Griffin MR, et al. Effectiveness of live attenuated influenza vaccine and inactivated influenza vaccine in children 2-17 years of age in 2013-2014 in the United States. Vaccine. 2016;34(1):77–82.
  17. Pierse N, Kelly H, Thompson MG, Bissielo A, Radke S, Huang QS, et al. Influenza vaccine effectiveness for hospital and community patients using control groups with and without non-influenza respiratory viruses detected, Auckland, New Zealand 2014. Vaccine [Internet]. 2016;34(4):503–9. Available from: http://dx.doi.org/10.1016/j.vaccine.2015.11.073
  18. Blyth CC, Jacoby P, Effler P V., Kelly H, Smith DW, Borland ML, et al. Influenza vaccine effectiveness and uptake in children at risk of severe disease. Pediatr Infect Dis J. 2016;35(3):309–15.
  19. Blyth CC, Richmond PC, Jacoby P, Thornton P, Regan A, Robins C, et al. The impact of pandemic A(H1N1)pdm09 influenza and vaccine-associated adverse events on parental attitudes and influenza vaccine uptake in young children. Vaccine [Internet]. 2014;32(32):4075–81. Available from: http://dx.doi.org/10.1016/j.vaccine.2014.05.055
  20. Shinjoh M, Sugaya N, Furuichi M, Araki E, Maeda N, Isshiki K, et al. Effectiveness of inactivated influenza vaccine in children by vaccine dose, 2013–18. Vaccine [Internet]. 2019;37(30):4047–54. Available from: https://doi.org/10.1016/j.vaccine.2019.05.090
  21. Sugaya N, Shinjoh M, Nakata Y, Tsunematsu K, Yamaguchi Y, Komiyama O, et al. Three-season effectiveness of inactivated influenza vaccine in preventing influenza illness and hospitalization in children in Japan, 2013–2016. Vaccine [Internet]. 2018;36(8):1063–71. Available from: https://doi.org/10.1016/j.vaccine.2018.01.024
  22. Redfield RR, Bunnell R, Greenspan A, Kent CK, Leahy MA, Martinroe JC, et al. Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices-United States, 2020-21 Influenza Season Morbidity and Mortality Weekly Report Recommendations and Reports Centers for Disease C. Recomm Reports [Internet]. 2020;69(8). Available from: https://www.cdc.gov/
  23. Feldstein LR, Ogokeh C, Rha B, Weinberg GA, Staat MA, Selvarangan R, et al. Vaccine Effectiveness against Influenza Hospitalization among Children in the United States, 2015-2016. J Pediatric Infect Dis Soc. 2021;10(2):75–82.
  24. Rolfes MA, Goswami D, Sharmeen AT, Yeasmin S, Parvin N, Nahar K, et al. Efficacy of trivalent influenza vaccine against laboratory-confirmed influenza among young children in a randomized trial in Bangladesh. Vol. 35, Vaccine. 2017. p. 6967–76.
  25. McMenamin ME, Bond HS, Sullivan SG, Cowling BJ. Estimation of Relative Vaccine Effectiveness in Influenza: A Systematic Review of Methodology. Epidemiology. 2022;33(3):334–45.
  26. Segaloff HE, Leventer-Roberts M, Riesel D, Malosh RE, Feldman BS, Shemer-Avni Y, et al. Influenza Vaccine Effectiveness against Hospitalization in Fully and Partially Vaccinated Children in Israel: 2015-2016, 2016-2017, and 2017-2018. Clin Infect Dis. 2019;69(12):2153–61.
  27. Chiu SS, Kwan MYW, Feng S, Wong JSC, Leung CW, Chan ELY, et al. Influenza vaccine effectiveness against influenza A(H3N2) hospitalizations in children in Hong Kong in a prolonged season, 2016/2017. J Infect Dis. 2018;217(9):1365–71.
  28. Campbell AP, Ogokeh C, Weinberg GA, Boom JA, Englund JA, Williams J V., et al. Effect of Vaccination on Preventing Influenza-Associated Hospitalizations among Children during a Severe Season Associated with B/Victoria Viruses, 2019-2020. Clin Infect Dis. 2021;73(4):E947–54.
  29. Wells G, Shea B, Robertson J, Peterson J, Welch V, Losos M. The Newcastle-Ottawa Scale ( NOS ) for Assessing the Quality of Nonrandomized Studies in Meta- Analysis Bias and Confounding Newcastle-Ottowa Scale. Ottawa Hosp Res Inst [Internet]. 2012; Available from: http://www.evidencebasedpublichealth.de/download/Newcastle_Ottowa_Scale_Pope_Bruce.pdf
  30. Arriola CS, Omeiri N El, Azziz-Baumgartner E, Thompson MG, Sotomayor-Proschle V, Fasce RA, et al. Influenza vaccine effectiveness against hospitalizations in children and older adults—Data from South America, 2013–2017. A test negative design. Vaccine X. 2019;(3):100047.
  31. Darvishian M, Heuvel ER van den, Bissielo A, Castilla J, Cohen C, Englund H, et al. Eff ectiveness of seasonal infl uenza vaccination in community-dwelling elderly people: an individual participant data meta-analysis of test-negative design case-control studies. Lancet Respir Med. 2017;5(3):200–11.
  32. Stuurman AL, Bollaerts K, Alexandridou M, Biccl. Vaccine effectiveness against laboratory-confirmed influenza in Europe – Results from the DRIVE network during season 2018/19. Vaccine. 2020;38(41).
  33. Zhang Y, Wub P, Feng L, Yang P, Pan Y, Feng S, et al. Influenza vaccine effectiveness against influenza-associated hospitalization in 2015/16 season, Beijing, China. Vaccine. 2017;35(23):3129–34.
  34. Omeiri N El, Azziz-Baumgartner E, Thompson MG, the REVELAC-i network participants. Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza hospitalizations – Latin America, 2013. Vaccine. 2018;36(24):3555–66.
  35. Maltezou H, Asimakopoulos G, Stavrou S, Daskalakis, G, Koutroumanis P, Sindos M, et al. Effectiveness of quadrivalent influenza vaccine in pregnant women and infants, 2018–2019. Vaccine. 2020;38(29):4625–3.
  36. Jacksona ML, Rothmanb KJ. Effects of imperfect test sensitivity and specificity on observational studies of influenza vaccine effectiveness. Vaccine. 2015;33(11):1313–6.
  37. Buchan SA, Chung H, Campitelli MA, Crowcroft NS, Gubbay JB, Karnauchow T, et al. Vaccine effectiveness against laboratory-confirmed influenza hospitalizations among young children during the 2010-11 to 2013-14 influenza seasons in Ontario, Canada. PLoS One. 2017;12(11):1–15.
  38. Owusu D, Hand J, Tenforde MW, Feldstein LR, DaSilva J, Barnes J, et al. Early season pediatric influenza B/Victoria virus infections associated with a recently emerged virus subclade — Louisiana, 2019. Am J Transplant. 2020;20(2):606–9.
  39. Epperson S, Davis CT, Brammer L, Abd Elal AI, Ajayi N, Barnes J, et al. Update: Influenza Activity — United States and Worldwide, May 19–September 28, 2019, and Composition of the 2020 Southern Hemisphere Influenza Vaccine. MMWR Morb Mortal Wkly Rep. 2019;68(40):880–4.
  40. Olson SM, Newhams MM, Halasa NB, Feldstein LR, Novak T, Weiss SL, et al. Vaccine Effectiveness Against Life-Threatening Influenza Illness in US Children. Clin Infect Dis. 2022;(Xx Xx):1–9.
  41. Mouratidou E, Lambrou A, Andreopoulou A, Gioula G, Exindari M, Kossyvakis A, et al. Influenza vaccine effectiveness against hospitalization with laboratory-confirmed influenza in Greece a pooled analysis across six seasons, 2013–2014 to 2018–2019. Vaccine. 2020;38(12):2715–24.
  42. Dawood F, Chung JR, Kim SS, Kondor RJ, Smith C, Budd AP, et al. Interim Estimates of 2019–20 Seasonal Influenza Vaccine Effectiveness — United States, February 2020. 2020;71(10).
  43. Cowling BJ, Chan KH, Feng S, Chan ELY, Lo JYC, Peiris JSM, et al. The effectiveness of influenza vaccination in preventing hospitalizations in children in Hong Kong, 2009-2013. Vaccine [Internet]. 2014;32(41):5278–84. Available from: http://dx.doi.org/10.1016/j.vaccine.2014.07.084
  44. Restivo V, Costantino C, Bono S, Maniglia M, Marchese V, Ventura G, et al. Influenza vaccine effectiveness among high-risk groups: A systematic literature review and meta-analysis of case-control and cohort studies. Hum Vaccines Immunother [Internet]. 2018;14(3):724–35. Available from: https://doi.org/10.1080/21645515.2017.1321722
  45. Orrico-sánchez A, Valls-arévalo Á, Garcés-sánchez M, Álvarez J, Ortiz R, Leonardo DL. Efficacy and effectiveness of influenza vaccination in healthy children. A review of current evidence. Enferm Infecc Microbiol Clin [Internet]. 2022;(xxxx). Available from: https://doi.org/10.1016/j.eimc.2022.02.005
  46. Flannery B, Chung JR, Monto AS, Martin ET, Belongia EA, McLean HQ, et al. Influenza Vaccine Effectiveness in the United States during the 2016-2017 Season. Clin Infect Dis. 2019;68(11):1798–806.
  47. DiazGranados CA, Denis M, Plotkin S. Seasonal influenza vaccine efficacy and its determinants in children and non-elderly adults: A systematic review with meta-analyses of controlled trials. Vaccine [Internet]. 2012;31(1):49–57. Available from: http://dx.doi.org/10.1016/j.vaccine.2012.10.084
  48. Boddington NL, Pearson I, Whitaker H, Mangtani P, Pebody RG. Effectiveness of Influenza Vaccination in Preventing Hospitalization Due to Influenza in Children: A Systematic Review and Meta-analysis. Clinical Infectious Diseases. 2021 Nov 1;73(9):1722-32.
  49. Wu S, Pan Y, Zhang X, Zhang L, Duan W, Ma C, et al. Influenza vaccine effectiveness in preventing laboratory-confirmed influenza in outpatient settings: A test-negative case-control study in Beijing, China, 2016/17 season. Vol. 36, Vaccine. 2018. p. 5774–80.

How to Cite

Sadnyani, D. A. K. O., Wiraningrat, . . I. G. A. A. N., & Windiyanto, R. (2022). Efektivitas vaksin influenza terhadap kejadian rawat inap pada anak dengan influenza: sebuah tinjauan sistematik dan meta analisis. Intisari Sains Medis, 13(3), 590–598. https://doi.org/10.15562/ism.v13i3.1483
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
0

Total
0

Share

Search Panel

Dewa Ayu Ketut Oka Sadnyani
Google Scholar
Pubmed
ISM Journal

I Gusti Agung Ayu Novi Wiraningrat
Google Scholar
Pubmed
ISM Journal

Romy Windiyanto
Google Scholar
Pubmed
ISM Journal