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Hubungan antara subtipe intrinsik dengan faktor risiko indeks massa tubuh pada pasien kanker payudara yang datang di Rumah Sakit Umum Ganesha selama periode 2019-2021

Abstract

Background: Breast cancer is a malignancy that occurs in the breast tissue of the ductal epithelium and lobules of the breast. Indonesia, in this case, ranked first out of the four countries with the highest number of breast cancer cases, namely 58.265 new cases found and 22.692 death cases. Goldhirsch et al. found a classification of breast cancer based on the results of immunohistochemistry (IHC) staining of estrogen, progesterone, and human epidermal growth factor receptor 2 (HER2) receptors using fluorescent in situ hybridization. The classification was determined genetically and molecularly, namely: luminal A, luminal B, HER2- overexpressed cancer and triple negative (basal like) cancer. Obesity which is rated using the body mass index (BMI) is one of the risk factors for some cancers, including postmenopausal breast cancer and especially estrogen receptor (ER)-positive/progesterone receptor (PR)-positive breast cancer. Rose et al stated that obesity is inversely related to pre-menopausal breast cancer, where obesity is a protective factor.

Methods: The research plan for this research is research with a cross-sectional research design which will be using purposive sampling type of non-probability sampling as the sample selection technique.

Result: There are 94 medical records of breast cancer patients who visit Rumah Sakit Umum Ganesha (Ganesha Public Hospital). The value found from the analysis that has been done between the intrinsic subtype and BMI (body mass index) risk factors is p>0.05 which means there is no correlation between the two.

Conclusion: There is no relationship between the patient’s body mass index (BMI) with intrinsic subtypes in breast cancer patients.

 

Latar Belakang: Kanker payudara merupakan keganasan pada jaringan payudara yang berasal dari epitel duktus maupun lobulusnya. Indonesia merupakan peringkat pertama dari empat negara yang memiliki jumlah kasus kanker payudara tertinggi yaitu sebesar 58.265 kasus baru yang ditemukan dan sebanyak 22.692 kasus mengalami kematian. Goldhirsch et al. menemukan klasifikasi kanker payudara berdasarkan hasil pewarnaan imunohistokimia (IHK) dari reseptor estrogen, progesteron, dan human epidermal growth factor receptor 2 (HER2) menggunakan hibridisasi in situ fluoresen. Klasifikasi tersebut ditentukan secara genetik dan molekuler, yaitu: kanker luminal A, luminal B, HER2- yang diekspresikan secara berlebihan dan kanker triple negative (basal like). Obesitas yang dinilai melalui indeks massa tubuh (IMT) merupakan salah satu faktor risiko timbulnya beberapa kanker, termasuk pascamenopause kanker payudara dan khususnya reseptor estrogen (ER)-positif/ reseptor progesterone (PR)-positif kanker payudara. Rose et al menyebutkan bahwa obesitas berbanding terbalik dengan perimenopause kanker payudara, dimana obesitas merupakan faktor protektif.

Metode: Rancangan penelitian ini menggunakan desain penelitian cross-sectional dengan pemilihan sampel menggunakan teknik non-probability sampling jenis purposive sampling.

Hasil: Didapatkan 94 rekam medis pasien kanker payudara yang datang di Rumah Sakit Umum Ganesha. Dari hasil analisis yang dilakukan antara subtipe intrinsik dengan faktor risiko indeks massa tubuh (IMT) memiliki nilai p>0.05 yang memiliki arti tidak terdapat hubungan antara keduanya.

Simpulan: Tidak terdapat hubungan antara indeks massa tubuh (IMT) pasien dengan subtipe intrinsik pada pasien kanker payudara.

References

  1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: Globocan 2008. International Journal of Cancer. 2010;127(12):2893-2917. doi:10.1002/ijc.25516.
  2. Kementerian Kesehatan Republik Indonesia. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Kanker Payudara. 2018.
  3. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021 [published correction appears in CA Cancer J Clin. 2021 Jul;71(4):359]. CA Cancer J Clin. 2021;71(1):7-33. doi:10.3322/caac.21654.
  4. Tao Z, Shi A, Lu C, Song T, Zhang Z, Zhao J. Breast Cancer: Epidemiology and Etiology. Cell Biochem Biophys. 2015;72(2):333-338. doi:10.1007/s12013-014-0459-6.
  5. Łukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, Stanisławek A. Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review. Cancers (Basel). 2021;13(17):4287. Published 2021 Aug 25. doi:10.3390/cancers13174287.
  6. Ghoncheh M, Momenimovahed Z, Salehiniya H. Epidemiology, Incidence and Mortality of Breast Cancer in Asia. Asian Pac J Cancer Prev. 2016;17(S3):47-52. doi:10.7314/apjcp.2016.17.s3.47.
  7. Goldhirsch A, Winer EP, Coates AS, et al. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol. 2013;24(9):2206-2223. doi:10.1093/annonc/mdt303.
  8. Vona-Davis L, Howard-McNatt M, Rose DP. Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer. Obes Rev. 2007;8(5):395-408. doi:10.1111/j.1467-789X.2007.00396.x.
  9. Rose DP, Gracheck PJ, Vona-Davis L. The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer. Cancers (Basel). 2015;7(4):2147-2168. Published 2015 Oct 26. doi:10.3390/cancers7040883.
  10. Vance V, Mourtzakis M, McCargar L, Hanning R. Weight gain in breast cancer survivors: prevalence, pattern and health consequences. Obes Rev. 2011;12(4):282-294. doi:10.1111/j.1467-789X.2010.00805.x.
  11. Firasi AA, Jkd Y, Yudhanto E. Hubungan usia terhadap derajat diferensiasi kanker payudara pada wanita. Diponegoro Medical Journal. 2016;5(4). p327-336. https://doi.org/10.14710/dmj.v5i4.14218.
  12. Wahidin M, Febrianti R, Susanty F, Hasanah SR. Twelve Years Implementation of Cervical and Breast Cancer Screening Program in Indonesia. Asian Pac J Cancer Prev. 2022;23(3):829-837. Published 2022 Mar 1. doi:10.31557/APJCP.2022.23.3.829.
  13. Kim Y, Yoo KY, Goodman MT. Differences in incidence, mortality and survival of breast cancer by regions and countries in Asia and contributing factors. Asian Pac J Cancer Prev. 2015;16(7):2857-2870. doi:10.7314/apjcp.2015.16.7.2857.
  14. Prawirohardjo AN, Soewoto W, and Alifianto U. The relationship of body massa index with grading on breast cancer. Biomedika. 2018;10(1). p41-45.
  15. Solikhah S, Lianawati L, Matahari R, Rejeki DSS. Determinants of Breast Cancer Screening Practice among Women in Indonesia: A Nationwide Study. Asian Pac J Cancer Prev. 2021;22(5):1435-1441. Published 2021 May 1. doi:10.31557/APJCP.2021.22.5.1435.
  16. Sun L, Zhu Y, Qian Q, Tang L. Body mass index and prognosis of breast cancer: An analysis by menstruation status when breast cancer diagnosis. Medicine (Baltimore). 2018;97(26):e11220. doi:10.1097/MD.0000000000011220.
  17. Hillers LE, D'Amato JV, Chamberlin T, Paderta G, Arendt LM. Obesity-Activated Adipose-Derived Stromal Cells Promote Breast Cancer Growth and Invasion. Neoplasia. 2018;20(11):1161-1174. doi:10.1016/j.neo.2018.09.004.
  18. Kawai M, Tomotaki A, Miyata H, et al. Body mass index and survival after diagnosis of invasive breast cancer: a study based on the Japanese National Clinical Database-Breast Cancer Registry. Cancer Med. 2016;5(6):1328-1340. doi:10.1002/cam4.678.
  19. Warjianto, Soewoto W, Alifianto U, dan Wujoso H. Hubungan reseptor estrogen, reseptor progesterone, dan ekspresi Her-2/Neu dengan grading histopatologi pada pasien kanker payudara di RSUD dr. Moewardi Surakarta. Smart Medical Journal. 2020;3(2). p96-104. doi:10.13057/smj.v3i1.35228.
  20. Goldhirsch A, Wood WC, Coates AS, et al. Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 2011;22(8):1736-1747. doi:10.1093/annonc/mdr304.
  21. Purnawaty A, Hamdani W, Djaya Ganda I. Relationship of Grade, Intrinsic subtype and clinical response to neoadjuvant chemotherapy in breast cancer. IJSBAR. 2018;37(1). p34-42.
  22. Kimura K, Tanaka S, Iwamoto M, et al. Association between body mass index and breast cancer intrinsic subtypes in Japanese women. Exp Ther Med. 2012;4(3):391-396. doi:10.3892/etm.2012.621.
  23. Ademi-Islami D, Manxhuka-Kerliu S, Tarifa-Koroveshi D, Koliqi R, Mujaj B. Metabolic Syndrome and Breast Cancer Molecular Subtypes: An Observational Patient Study. Breast Cancer (Auckl). 2022;16:11782234221080555. Published 2022 Mar 23. doi:10.1177/11782234221080555.
  24. Benefield HC, Zabor EC, Shan Y, Allott EH, Begg CB, Troester MA. Evidence for Etiologic Subtypes of Breast Cancer in the Carolina Breast Cancer Study. Cancer Epidemiol Biomarkers Prev. 2019;28(11):1784-1791. doi:10.1158/1055-9965.EPI-19-0365.
  25. Gershuni V, Li YR, Williams AD, et al. Breast cancer subtype distribution is different in normal weight, overweight, and obese women. Breast Cancer Res Treat. 2017;163(2):375-381. doi:10.1007/s10549-017-4192-x.
  26. Momenimovahed Z, Salehiniya H. Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer (Dove Med Press). 2019;11:151-164. doi:10.2147/BCTT.S176070.
  27. Bhushan A, Gonsalves A, Menon JU. Current State of Breast Cancer Diagnosis, Treatment, and Theranostics. Pharmaceutics. 2021;13(5):723. Published 2021 May 14. doi:10.3390/pharmaceutics13050723.

How to Cite

Cahyanti, I. G. A. T. D., Wijaya, S. ., & Ruslim, W. H. . (2023). Hubungan antara subtipe intrinsik dengan faktor risiko indeks massa tubuh pada pasien kanker payudara yang datang di Rumah Sakit Umum Ganesha selama periode 2019-2021. Intisari Sains Medis, 14(1), 190–196. https://doi.org/10.15562/ism.v14i1.1478

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I Gusti Ayu Tania Dwi Cahyanti
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Sony Wijaya
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Welly Hartono Ruslim
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