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The outcome of early rehabilitation therapy for the patient after percutaneous coronary intervention: a systematic review and meta-analysis


Background: Acute myocardial infarction (AMI) is one of the leading causes of mortality, morbidity and physical disability worldwide. The chief treatment for AMI is primary percutaneous coronary intervention (PCI). However, the effectiveness of early rehabilitation therapy after PCI patients still lacks documentation. Therefore, a meta-analysis has assessed the patient's outcome of early rehabilitation therapy after PCI.

Methods: The searching protocol was carried out using several databases, such as PubMed, ScienceDirect, and Google Scholar, to identify relevant topics in June 2022. This study used the Preferred Reporting Items for Systematic Review and Meta-Analysis 2020 (PRISMA) guidelines.

Result: There were nine studies included in this systematic review and meta-analysis. All of the reviewed studies were written in English. Most of the included studies were carried out in China. Most of the included studies were carried out in China. The mean age of the patient were all above 18 years. The total participants were 858 patients with PCI. There was a significant difference in 6-minute walk distance (MD = 85.64; 95% CI = 78.68–92.60; p < 0.01); left ventricle ejection fraction (LVEF) (MD = 5.97; 95% CI = 5.30–6.63; p < 0.01) and body mass index (BMI) score score (MD = 1.43; 95% CI = 0.86–2.00; p < 0.01) between groups in overall analysis.

Conclusion: Early rehabilitation in patients with PCI has better outcomes (6-minutes walk distances, LVEF, and BMI score) than in the control group.


  1. Dani SS, Lone AN, Javed Z, Khan MS, Khan MZ, Kaluski E, et al. Trends in Premature Mortality From Acute Myocardial Infarction in the United States, 1999 to 2019. J Am Heart Assoc. 2022;11(1).
  2. Ozaki Y, Hara H, Onuma Y, Katagiri Y, Amano T, Kobayashi Y, et al. CVIT expert consensus document on primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) update 2022. Vol. 37, Cardiovascular Intervention and Therapeutics. Springer Singapore; 2022. 1–34 p.
  3. Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, et al. Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association. Vol. 145, Circulation. 2022. 153–639 p.
  4. Kofoed KF, Kelbæk H, Riis Hansen P, Torp-Pedersen C, Høfsten D, Kløvgaard L, et al. Early versus standard care invasive examination and treatment of patients with non-ST-segment elevation acute coronary syndrome verdict randomized controlled trial. Circulation. 2018;138(24):2741–50.
  5. Gonzalez-Jaramillo N, Marcin T, Matter S, Eser P, Berlin C, Bano A, et al. Clinical outcomes and cardiac rehabilitation in underrepresented groups after percutaneous coronary intervention: an observational study. Eur J Prev Cardiol. 2022;29(7):1093–103.
  6. Xiao M, Li Y, Guan X. Community-based physical rehabilitation after percutaneous coronary intervention for acute myocardial infarction. Texas Hear Inst J. 2021;48(2):2–5.
  7. Ohbe H, Nakamura K, Uda K, Matsui H, Yasunaga H. Effect of early rehabilitation on physical function in patients undergoing coronary artery bypass grafting: A nationwide inpatient database study. J Clin Med. 2021;10(4):1–10.
  8. Cai H, Cao P, Zhou W, Sun W, Zhang X, Li R, et al. Effect of early cardiac rehabilitation on prognosis in patients with heart failure following acute myocardial infarction. BMC Sports Sci Med Rehabil. 2021;13(1):1–13.
  9. Shajrawi A, Granat M, Jones I, Astin F. Physical Activity and Cardiac Self-Efficacy Levels during Early Recovery after Acute Myocardial Infarction: A Jordanian Study. J Nurs Res. 2021;29(1).
  10. Zhang Y, Cao HX, Jiang P, Tang HQ. Cardiac rehabilitation in acute myocardial infarction patients after percutaneous coronary intervention. Med (United States). 2018;97(8).
  11. Xu L, Cai Z, Xiong M, Li Y, Li G, Deng Y, et al. Efficacy of an early home-based cardiac rehabilitation program for patients after acute myocardial infarction: A three-dimensional speckle tracking echocardiography randomized trial. Med (United States). 2016;95(52).
  12. Imamura T. Implication of early cardiac rehabilitation following acute myocardial infarction. J Cardiol. 2022;79(1):161–2.
  13. Smarz K, Jaxa-Chamiec T, Zaborska B, Tysarowski M, Budaj A. Mechanisms of exercise capacity improvement after cardiac rehabilitation following myocardial infarction assessed with combined stress echocardiography and cardiopulmonary exercise testing. J Clin Med. 2021;10(18).
  14. Kim C, Kim DY, Lee DW. The Impact of Early Regular Cardiac Rehabilitation Program on Myocardial Function after Acute Myocardial Infarction. Ann Rehabil Med. 2011;35(4):535.
  15. Page M, McKenzie J, Bossuyt P, Boutron I, Hoffman T, Mulrow C. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
  16. Qu B, Hou Q, Men X, Zhai X, Jiang T, Wang R. Research and application of KABP nursing model in cardiac rehabilitation of patients with acute myocardial infarction after PCI. Am J Transl Res. 2021;13(4):3022–33.
  17. Belardinelli R, Paolini I, Cianci G, Piva R, Georgiou D, Purcaro A. Exercise training intervention after coronary angioplasty: The ETICA trial. J Am Coll Cardiol. 2001;37(7):1891–900.
  18. Vasiliauskas D, Benetis R, Jasiukeviciene L, Grizas V, Marcinkeviciene J, Navickas R, et al. Exercise training after coronary angioplasty improves cardiorespiratory function. Scand Cardiovasc J. 2007;41(3):142–8.
  19. Jelinek HF, Huang ZQ, Khandoker AH, Chang D, Kiat H. Cardiac rehabilitation outcomes following a 6-week program of PCI and CABG Patients. Front Physiol. 2013;4(OCT):1–7.
  20. Zheng H, Luo M, Shen Y, Ma Y, Kang W. Effects of 6 months exercise training on ventricular remodelling and autonomic tone in patients with acute myocardial infarction and percutaneous coronary intervention. J Rehabil Med. 2008;40(9):776–9.
  21. Arevström L, Bergh C, Landberg R, Wu H, Rodriguez-Mateos A, Waldenborg M, et al. Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction: an open-label randomized clinical trial. Nutr Res. 2019;62:13–22.
  22. Peng X, Zhang J, Wan L, Wang H, Zhang W. The effect of a seven-step rehabilitation training program on cardiac function and quality of life after percutaneous coronary intervention for acute myocardial infarction. Pakistan J Med Sci. 2022;38(1):123–7.
  23. Piao JJ, Wan B, Zhao H, Shang Z, Yan L, Hao Z, et al. Effects of different brisk walking intensities on adherence and cardiorespiratory endurance of cardiac rehabilitation among patients with CHD after PCI: Protocol for a randomised controlled trial. BMJ Open. 2022;12(4):1–7.
  24. Candjondjo P, Vaz E, Marques S, Moreira J. STEMI-CR: Solution for Patients with Acute Myocardial Infarction at Home-Based Cardiac Rehabilitation Program. Procedia Comput Sci. 2021;196(2021):561–5.
  25. Sunamur M, Ter Hoeve N, Geleijnse M, Steenaard R, van den Berg-Emons H, Boersma H, et al. Cardiac re- habilitation in patients who underwent primary percutaneous coronary intervention for acute myocardial infarction: determinants of pro- gramme participation and completion. Neth Hear J. 2017;25:618–28.
  26. Diniz LS, Neves VR, Starke AC, Barbosa MPT, Britto RR, Ribeiro ALP. Safety of early performance of the six-minute walk test following acute myocardial infarction: a cross-sectional study. Brazilian J Phys Ther. 2017;21(3):167–74.
  27. Vegh EM, Kandala J, Orencole M, Upadhyay GA, Sharma A, Miller A, et al. Device-measured physical activity versus six-minute walk test as a predictor of reverse remodeling and outcome after cardiac resynchronization therapy for heart failure. Am J Cardiol. 2014;113(9):1523–8.
  28. Wells G, Shea B, Robertson J, Peterson J, Welch V, Losos M. The Newcastle-Ottawa Scale ( NOS ) for Assessing the Quality of Nonrandomized Studies in Meta- Analysis Bias and Confounding Newcastle-Ottowa Scale. Ottawa Hosp Res Inst. 2012;

How to Cite

Budiarta, P. M. D., Prawira S, A. N. ., Sofyan, C. W., & Bagaskara, P. T. . (2022). The outcome of early rehabilitation therapy for the patient after percutaneous coronary intervention: a systematic review and meta-analysis. Intisari Sains Medis, 13(2), 480–486.




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