Research Article

Korelasi antara kadar testosteron total dengan trans epidermal water loss (TEWL) pada pria late onset hypogonadism

Daniel Widiyanto , Reny I’tishom

Daniel Widiyanto
Program Studi Spesialis Andrologi, Fakultas Kedokteran Universitas Airlangga, Surabaya-Indonesia. Email: Daniel.widiyanto@gmail.com

Reny I’tishom
Program Studi Spesialis Andrologi, Fakultas Kedokteran Universitas Airlangga, Surabaya-Indonesia
Online First: January 02, 2018 | Cite this Article
Widiyanto, D., I’tishom, R. 2018. Korelasi antara kadar testosteron total dengan trans epidermal water loss (TEWL) pada pria late onset hypogonadism. Intisari Sains Medis 9(1). DOI:10.15562/ism.v9i1.144


Background: Late Onset Hypogonadism (LOH) is a clinical and biochemical condition in the elderly with testosterone levels below the reference value of young and healthy men, accompanied by symptoms of testosterone deficiency. Increased age or aging process is one of the factors causing sebaceous gland function decreased both regarding quantity and regarding quality associated with the function of lipid barrier. Decreased sebum gland function can be seen from several parameters, one of which is the increase of Trans Epidermal Water Loss (TEWL). Methods: This study was an observational analytic study with cross-sectional design to determine the relationship between total testosterone and TEWL in LOH men. This research was conducted in Outpatient Unit Andrology of dr. Soetomo from May 2017 to July 2017. 16 samples of elderly male patients (≥60 years) were selected using the consecutive sampling technique who met the inclusion and exclusion criteria. Performed total testosterone test and TEWL level examination by using Tewameter to the research sample. Interpretation of results adjusted to Research and Development Department, Courage & Khazaka Electronics GmbH, Koln, Germany. Results: The Total testosterone levels of the patient were ranged from 146.11 - 575.10 ng/dL with a mean of 351.67 ng/dL and standard deviation of 116.34. The TEWL level of the patients was ranged from 17.2 - 50.8 g/jam/m2 with a mean of 31 g/jam/m2 and standard deviation of 9.20. The correlation coefficient value between total testosterone and TEWL was -0.853 with a significance of 0.0001 (p <0.05). Conclusion: There was a significant relationship between total testosterone and TEWL. The association of total testosterone with TEWL is unidirectional. The lower the testosterone level, the higher the TEWL value.

References

Alvarado, LC. 2011. Total Testosteron In Young Men Is More Closely Associated Than Free Testosteron With Prostate Cancer Disparities. Therapeutic Advance in Urology, Jun; 3(3):99-106

Badan Pusat Statistik. 2014. Angka Harapan Hidup Penduduk Beberapa Negara (tahun), 1995-2015, https://www.bps.go.id. Diakses pada 16 Maret 2017 23.13 pm.

Fleischer JR, Feldman SR, Katz AS, Clayton BD. 2005. Xerosis. In Fleicher JR, Feldman SR, Katz AS, Clayton BD, editors. 20 Common Problems In Dermatology, 265-76. Imago USA: McGraw-Hill CO.

Fluhr, J.W., Feingold, K.R. and Elias, P.M. 2006. 'Transepidermal Water Loss Reflects Permeability Barrier Status: Validation In Human And Rodent In Vivo And Ex Vivo Models'. Journal of Experimental Dermatology;15: 483-492.

Gloor M, Tribskorn A. 2013. Non invassive methods for the determination of skin hydration. In Frosch PJ, Kligman AM (eds). Noninvassive methods for the quantification of skin functions, ed 5, 42-55. London: Springer-Verlag.

Huhtaniemi J. 2014. Late Onset Hypogonadism: Current Concepts and Controversies of Pathogenesis, Diagnosis and Treatment. Asian Journal of Andrology; Mar-Apr; 16(2):192-202

Kaufman JM, Vermeulen A. 2005. The Decline of Androgen Levels in Eldery Men and Its Clinical and Therapeutic Implications. Endocrinology Review; Oct; 26(6):833-76.

Luca D.C., Valacchi G. 2010. Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli. Mediators of Inflamation; 2010(2010):1-11

Lunenfeld B, Mskhalaya G, Kalinchenko S. 2013. Recommendations on The Diagnosis, Treatment and Monitoring of Late Onset Hypogonadism in Men Suggested Update. The Aging Male; 16(4):143-150

Kapoor D, Malkin CJ, Channer KS, Jones TH. 2005. Androgens, Insulin Resistance and Vascular Disease in Men. Clinical Endocrinology; 63(3):239-250

Mundlein M, Valentin BR, Chabicovsky R, Nicolics J, Weremczuk J. 2013. Transepidermal Water Loss (TEWL) Measurements With Novel Sensors Based On Diferent Sensing Principles. Journal of Dermatology and Technology;1: 103-10.

Nieschlag E, Swerdloff R, Behre HM. 2005. International Society of Andrology (ISA); International Society for the Study of the Aging Male (ISSAM); European Association of Urology (EAU). Investigation, treatment and monitoring of late onset hypogonadism in males. ISA, ISSAM, and EAU recommendations. European Urology; Jul; 48(1):1-4

Picardo M, Ottaviani M, Camera E, Mastrofrancesco A. 2009. Sebaceous Gland Lipids. Dermato Endocrinology; Mar-Apr; 1(2):68-71

Retno, IST. 2003. Peranan Antioksidan Dalam Kosmetika Untuk Menghambat Proses Penuaan Kulit. In Seminar nasional, Peran Antioksidan Dalam Menghambat Proses Penuaan, 1-15. Fakultas Kedokteran Universitas Sultan Agung. Semarang

Rolf C, Zittman M, Nieschlag E. 2010. The Aging Male and Late Onset Hypogonadism in Andrology; 249-253. Berlin Heidelberg: Springer-Verlag.

Scholerman AG, Bochita JB, Bohnsack K. 2008. Skin Aging. Journal of Dermatology Treatment;2:175-9.

Smith, K. R. and D. M. Thiboutot. 2008. Sebaceous Gland Lipids: Friend or Foe?, Journal of Lipid Research; 49:271-281

Thiboutot D. 2004. Regulation of Human Sebaceous Glands. The Journal of Investigation Dermatology; 123:1-12


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