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Hubungan bayi berat lahir rendah dan prematuritas dengan kejadian sepsis neonatorum di RSUD Wangaya, Denpasar, Bali, Indonesia

Abstract

Background: Infant mortality death is still high, 24 per 1,000 live births, and this is still far from the target of the Sustainable Development Goals (SDG) to decrease the infant mortality rate to 12 per 1,000 live births in 2030. One of the causes of the high burden of infant mortality rate is neonatal sepsis. There are some risk factors that contribute to neonatal sepsis, such as low birth weight and prematurity. The aim of this study was to determine if there were a correlation between low birth weight and prematurity with neonatal sepsis in Wangaya regional general hospital.

Methods: This was an observational analytic study with a cross-sectional design. All data were obtained from secondary data from medical records of patients that were hospitalized in neonatal intensive unit care and perinatology room in Wangaya regional general hospital from January until December 2019. The collected data will be analyzed by univariate and bivariate analysis with statistical Chi-Square at a 95% confidence interval.

Results: Total samples in this study were 50 neonates. The prevalence of neonatal sepsis in this study was 12 neonates (24%), with 6 neonates having early-onset neonatal sepsis (EOS) and 6 neonates having late-onset neonatal sepsis (LOS). Seventeen neonates (34%) were in the low birth weight category, and 15 neonates (30%) were premature. In bivariate analysis, we found that low birth weight had a p-value of 0.009, a prevalence ratio of 3.9, with a 95% CI of 1.36 – 11.07. Meanwhile, prematurity had a p-value of 0.003 with a prevalence ratio of 4.7, with a 95% CI of 1.66 – 13.16.

Conclusion: There was a correlation between low birth weight and prematurity with neonatal sepsis in Wangaya regional general hospital.

 

Latar Belakang: Angka kematian neonatus hingga saat ini masih cukup tinggi yaitu 24 per 1.000 kelahiran hidup dan belum mencapai target Sustainable Development Goals (SDG) yaitu menurunkan angka kematian neonatus menjadi 12 per 1.000 kelahiran hidup pada tahun 2030. Salah satu penyebab tingginya angka kematian neonatus adalah sepsis neonatorum. Terdapat beberapa faktor risiko yang menyebabkan sepsis neonatorum, antara lain bayi berat lahir rendah (BBLR) dan prematuritas. Tujuan penelitian ini adalah untuk mengetahui hubungan antara BBLR dan prematuritas dengan kejadian sepsis neonatorum di RSUD Wangaya.

Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan cross-sectional.  Data penelitian diambil dari data sekunder, berupa rekam medis pasien yang dirawat di ruangan Perina dan Neonatal Intensive Care Unit (NICU) RSUD Wangaya pada periode Januari – Desember 2019. Data yang berhasil dikumpulkan akan dilakukan analisis bivariat menggunakan uji statistik Chi-Square pada interval kepercayaan (IK) 95%.

Hasil: Total sampel pada penelitian ini sebanyak 50 neonatus. Prevalensi sepsis neonatorum pada penelitian ini sebanyak 12 bayi (24%), dengan rincian 6 bayi (50%) menderita sepsis neonatal awitan dini (SNAD) dan sisanya 6 bayi (50%) menderita sepsis neonatal awitan lambat (SNAL). Jumlah bayi BBLR sebanyak 17 bayi (34%) dan prematur sebanyak 15 bayi (30%). Hasil analisis bivariat didapatkan faktor BBLR memiliki p-value 0,009; rasio prevalens (RP) 3,9 dengan 95% IK 1,36 – 11,07, sedangkan faktor prematuritas memiliki p-value 0,003; RP 4,7 dengan 95% IK 1,66 – 13,16.

Simpulan: Terdapat hubungan antara BBLR dan prematuritas dengan sepsis neonatorum di RSUD Wangaya.

References

  1. Ou Z, Yu D, Liang Y, et al. Global trends in incidence and death of neonatal disorders and its specific causes in 204 countries/territories during 1990-2019. BMC Public Health. 2022;22(1):360. Published 2022 Feb 19. doi:10.1186/s12889-022-12765-1.
  2. Deviany PE, Setel PW, Kalter HD, et al. Neonatal mortality in two districts in Indonesia: Findings from Neonatal Verbal and Social Autopsy (VASA). PLoS One. 2022;17(3):e0265032. Published 2022 Mar 14. doi:10.1371/journal.pone.0265032.
  3. Gleason CA and Devaskar SU. Avery’s Diseases of the Newborn 9th ed. Elseiver Saunders. Philadelphia. 2012.
  4. Tran HT, Doyle LW, Lee KJ, Graham SM. A systematic review of the burden of neonatal mortality and morbidity in the ASEAN Region. WHO South East Asia J Public Health. 2012;1(3):239-248. doi:10.4103/2224-3151.207020.
  5. Singh M, Alsaleem M, Gray CP. Neonatal Sepsis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; September 29, 2022.
  6. Getabelew A, Aman M, Fantaye E, Yeheyis T. Prevalence of Neonatal Sepsis and Associated Factors among Neonates in Neonatal Intensive Care Unit at Selected Governmental Hospitals in Shashemene Town, Oromia Regional State, Ethiopia, 2017. Int J Pediatr. 2018;2018:7801272. Published 2018 Aug 2. doi:10.1155/2018/7801272.
  7. Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018;6(3):223-230. doi:10.1016/S2213-2600(18)30063-8.
  8. Junara P. Insidens dan faktor-faktor yang berhubungan dengan sepsis neonatorum di RSUP Sanglah Denpasar. Sari Pediatri. 2012;14(3). p205-210. DOI: http://dx.doi.org/10.14238/sp14.3.2012.205-10.
  9. Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017;390(10104):1770-1780. doi:10.1016/S0140-6736(17)31002-4.
  10. Utomo MT. Risk Factors of Neonatal Sepsis: A Preliminary Study in Dr. Soetomo Hospital. Indonesian Journal of Tropical and Infectious Disease. 2010;1(1). p.23-26. doi:10.20473/ijtid.v1i1.3718.
  11. Ocviyanti D, Wahono WT. Risk Factors for Neonatal Sepsis in Pregnant Women with Premature Rupture of the Membrane. J Pregnancy. 2018;2018:4823404. Published 2018 Oct 1. doi:10.1155/2018/4823404.
  12. Widayati K, Kurniati DPY, Windiani GAT. Faktor Risiko Sepsis Neonatorum di Ruang Perinatologi RSUP Denpasar. Public Health and Preventive Medicine Archive. 2016;4(1). p67-73.
  13. Montoya-Williams D, Lemas DJ, Spiryda L, et al. The Neonatal Microbiome and Its Partial Role in Mediating the Association between Birth by Cesarean Section and Adverse Pediatric Outcomes. Neonatology. 2018;114(2):103-111. doi:10.1159/000487102.
  14. Adatara P, Afaya A, Salia SM, et al. Risk Factors for Neonatal Sepsis: A Retrospective Case-Control Study among Neonates Who Were Delivered by Caesarean Section at the Trauma and Specialist Hospital, Winneba, Ghana. Biomed Res Int. 2018;2018:6153501. Published 2018 Dec 19. doi:10.1155/2018/6153501.
  15. Alemu M, Ayana M, Abiy H, Minuye B, Alebachew W, Endalamaw A. Determinants of neonatal sepsis among neonates in the northwest part of Ethiopia: case-control study. Ital J Pediatr. 2019;45(1):150. Published 2019 Nov 28. doi:10.1186/s13052-019-0739-2.
  16. Murthy S, Godinho MA, Guddattu V, Lewis LES, Nair NS. Risk factors of neonatal sepsis in India: A systematic review and meta-analysis. PLoS One. 2019;14(4):e0215683. Published 2019 Apr 25. doi:10.1371/journal.pone.0215683.
  17. Belachew A, Tewabe T. Neonatal sepsis and its association with birth weight and gestational age among admitted neonates in Ethiopia: systematic review and meta-analysis. BMC Pediatr. 2020;20(1):55. Published 2020 Feb 5. doi:10.1186/s12887-020-1949-x.
  18. Haque KN. Neonatal sepsis in the very low birth weight preterm infants : part 1 : review of pathophysiology. Journal of Medical Sciences. 2010;3(1). p1-10.
  19. Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am. 2013;60(2). p367-389. doi:10.1016/j.pcl.2012.12.003.
  20. Ferreira RC, Mello RR, Silva KS. Neonatal sepsis as a risk factor for neurodevelopmental changes in preterm infants with very low birth weight. J Pediatr (Rio J). 2014;90(3). p293-299. doi:10.1016/j.jped.2013.09.006.
  21. Kardana IM. Incidence and Factors Associated With Mortality of Neonatal Sepsis. Paediatrica Indonesiana. 2011;51(3). p144-8. doi:10.14238/pi51.3.2011.144-8.

How to Cite

Isella, V., Suryawan, I. W. B., & Dewi, M. R. (2023). Hubungan bayi berat lahir rendah dan prematuritas dengan kejadian sepsis neonatorum di RSUD Wangaya, Denpasar, Bali, Indonesia. Intisari Sains Medis, 14(1), 5–9. https://doi.org/10.15562/ism.v14i1.1395

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Virly Isella
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I Wayan Bikin Suryawan
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Made Ratna Dewi
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