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Myoepithelial carcinoma of lacrimal gland in HIV patient: A rare case


Introduction: Lacrimal gland tumors have 1: 1,000,000 cases per year, accounting for one-fourth of lesions that occupy the orbital space. The rarity of lacrimal gland tumors and the many types of tumors with various types of lesions make determining optimal treatment difficult. A myoepithelial tumor is a rare epithelial neoplasm of the lacrimal gland. This paper aims to report a good outcome case of myoepithelial carcinoma.

Case Report: A 30-year-old male complained of protruding his left eye since 2014, accompanied by pain and clear white discharge. The vision was getting blurry and also double vision. Patients with Human Immunodeficiency Virus (HIV) disease since 2013 on Anti Retro Viral (ARV) therapy. Right eye visual acuity was 6 / 7.5, and good eyeball examination. The left eye was 6/10 with no pinhole improvement, non-axial proptosis, and superolateral mass. The movement of his left eye was restricted. Other anterior and posterior segments were promising. The patient was diagnosed with pseudotumor and was given oral methylprednisolone. The eye condition is said to be getting better. The patient complained that the left eye was more prominent and protruding three years later, with blurred vision accompanied by infection. Left eye visual acuity becomes Light Perception Bad Projection with non-axial proptosis, retraction of palpebra and pus. Orbital exenteration was performed, and anatomical pathology examination revealed myoepithelial carcinoma of the lacrimal gland. The patient was planned for radiotherapy.

Conclusion: These rare cases have made setting up a regimen in randomized controlled trials difficult. The rapid development of therapy gives more hope to treating patients with lacrimal gland tumors.


  1. Andreasen, S., Esmaeli, B., Linea, S., Mikkelsen, L., Rasmussen, P. and Heegaard, S., 2017. An Update on Tumors of the Lacrimal Gland. Asia-Pacific Journal of Ophthalmology, 6, pp.159-172.
  2. Argyris, P., Pambuccian, S., Cayci, Z., Singh, C., Tosios, K. and Koutlas, I., 2012. Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma: Report of a Case and Review of Literature. Head and Neck Pathology, 7(1), pp.85-92.
  3. American Academy of Ophthalmology., 2018. 2018-2019 Basic and Clinical Science Course, Section 07: Amer Academy Of Ophthalmo, Pp.122-126.
  4. Weis, E., 2009. Epithelial Lacrimal Gland Tumors. Archives of Ophthalmology, 127(8), p.1016.
  5. Nizamuddin, I., Koulen, P. and McArthur, C., 2018. Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands. International Journal of Molecular Sciences, 19(9), p.2747.
  6. Mahdi, Y., Azami, M., Daoudi, R. and Cherradi, N., 2018. Diagnostic pitfall: primary myoepithelial carcinoma of the lacrimal gland, case report and literature review. BMC Clinical Pathology, 18(1).
  7. Wright, J., Stewart, W. and Krohel, G., 1979. Clinical presentation and management of lacrimal gland tumours. British Journal of Ophthalmology, 63(9), pp.600-606.
  8. Wright, J., Lloyd, G. and Ambrose, J., 1975. Computerized Axial Tomography in the Detection of Orbital Space-Occupying Lesions. American Journal of Ophthalmology, 80(1), pp.78-84.
  9. Zhang, F., Sha, Y., Qian, J., Huang, W., Li, X., Wang, S. and Ye, X., 2013. Role of magnetic resonance diffusion-weighted imaging in differentiating lacrimal masses. Journal of Magnetic Resonance Imaging, 40(3), pp.641-648.
  10. Wiwatwongwana, D., 2009. Unusual Carcinomas of the Lacrimal Gland: Epithelial-Myoepithelial Carcinoma and Myoepithelial Carcinoma. Archives of Ophthalmology, 127(8), p.1054.
  11. Esmaeli, B., Golio, D., Kies, M. and DeMonte, F., 2006. Surgical Management of Locally Advanced Adenoid Cystic Carcinoma of the Lacrimal Gland. Ophthalmic Plastic & Reconstructive Surgery, 22(5), pp.366-370.
  12. Esmaeli, B., 2014. Does Intra-arterial Chemotherapy Improve Survival for Lacrimal Gland Adenoid Cystic Carcinoma?. Ophthalmology, 121(1), pp.e7-e8.
  13. Esmaeli, B., Yin, V., Hanna, E., Kies, M., William, W., Bell, D. and Frank, S., 2016. Eye-sparing multidisciplinary approach for the management of lacrimal gland carcinoma. Head & Neck, 38(8), pp.1258-1262.
  14. Ahmad, S., Esmaeli, B., Williams, M., Nguyen, J., Fay, A., Woog, J., Selvadurai, D., Rootman, J., Weis, E., Selva, D., McNab, A., DeAngelis, D., Calle, A. and Lopez, A., 2009. American Joint Committee on Cancer Classification Predicts Outcome of Patients with Lacrimal Gland Adenoid Cystic Carcinoma. Ophthalmology, 116(6), pp.1210-1215.
  15. Woo, K., Yeom, A. and Esmaeli, B., 2016. Management of Lacrimal Gland Carcinoma. Ophthalmic Plastic and Reconstructive Surgery, 32(1), pp.1-10.
  16. Henderson, J., 1986. Past, present, and future surgical management of malignant epithelial neoplasms of the lacrimal gland. British Journal of Ophthalmology, 70(10), pp.727-731.

How to Cite

L.P. Suryantini Septia Dewi, Putu Yuliawati, made laksmiNi Made Laksmi Utari, & sukartiniA.A.A. Sukartini Djelantik. (2022). Myoepithelial carcinoma of lacrimal gland in HIV patient: A rare case. Intisari Sains Medis, 13(2), 460–465.




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L.P. Suryantini Septia Dewi
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Putu Yuliawati
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made laksmiNi Made Laksmi Utari
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sukartiniA.A.A. Sukartini Djelantik
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