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The role of Bone Morphogenetic Protein-2 in craniofacial osteogenesis: A literature review

  • I Gusti Putu Hendra Sanjaya ,
  • Sri Maliawan ,


Bone Morphogenetic Protein (BMP) is a type of growth factor that belongs to the Transforming Growth Factor Beta (TGF-B) group. Bone Morphogenetic Protein-2 (BMP-2) is recognized as one of the first commercially available osteoblast inductors. When new bone is needed, mesenchymal stem cells can develop into osteoblasts, which then implant as osteocytes in the bone, providing additional structure and support. The principal agent that differentiates stem cells into osteoblasts is BMP-2. BMP-2 will be released into the bone matrix or serum in performing their job. BMP-2 activates the SMAD1/5/8 signal via mediating the physiological action of type I and II serine/threoninekine receptors. The active SMAD protein will form a complex with the SMAD4 protein, translocate DNA to the nucleus, and bind to particular genes like Dlx-2/5, Osx, and transcription. According to a recent study, BMP-2 boosts osteogenic growth. BMPs are effective in the treatment of craniofacial defects in current research. The subjects of this paper are the molecular mechanism of BMPs and their involvement in the clinical application of craniofacial deformity patients.


  1. De Witte T, Fratila-Apachitei L, Zadpoor A, Peppas N. Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices. Regenerative Biomaterials. 2018;5(4):197-211.
  2. El Bialy I, Jiskoot W, Reza Nejadnik M. Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration. Pharmaceutical Research. 2017;34(6):1152-1170.
  3. Bmp2 bone morphogenetic protein 2 [Mus musculus (house mouse)] - Gene - NCBI [Internet]. 2022 [cited 9 February 2022]. Available from:
  4. Blázquez‐Medela A, Jumabay M, Boström K. Beyond the bone: Bone morphogenetic protein signaling in adipose tissue. Obesity Reviews. 2019;20(5):648-658.
  5. Poon B, Kha T, Tran S, Dass C. Bone morphogenetic protein-2 and bone therapy: successes and pitfalls. Journal of Pharmacy and Pharmacology. 2016;68(2):139-147.
  6. Halloran D, Durbano H, Nohe A. Bone Morphogenetic Protein-2 in Development and Bone Homeostasis. Journal of Developmental Biology. 2020;8(3):19.
  7. Mazziotta C, Lanzillotti C, Iaquinta M, Taraballi F, Torreggiani E, Rotondo J et al. MicroRNAs Modulate Signaling Pathways in Osteogenic Differentiation of Mesenchymal Stem Cells. International Journal of Molecular Sciences. 2021;22(5):2362.
  8. Lian J, Stein G, van Wijnen A, Stein J, Hassan M, Gaur T et al. MicroRNA control of bone formation and homeostasis. Nature Reviews Endocrinology. 2012;8(4):212-227.
  9. Bessa P, Casal M, Reis R. Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts). Journal of Tissue Engineering and Regenerative Medicine. 2008;2(1):1-13.
  10. Rahman M, Akhtar N, Jamil H, Banik R, Asaduzzaman S. TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation. Bone Research. 2015;3(1).
  11. Nakasa T, Yoshizuka M, Andry Usman M, Hussein Mahmoud E, Ochi M. MicroRNAs and Bone Regeneration. Current Genomics. 2015;16(999):1-1.
  12. Imafuji T, Shirakata Y, Shinohara Y, Nakamura T, Noguchi K. Enhanced bone formation of calvarial bone defects by low-intensity pulsed ultrasound and recombinant human bone morphogenetic protein-9: a preliminary experimental study in rats. Clinical Oral Investigations. 2021;25(10):5917-5927.
  13. Poldervaart M, Wang H, van der Stok J, Weinans H, Leeuwenburgh S, Öner F et al. Sustained Release of BMP-2 in Bioprinted Alginate for Osteogenicity in Mice and Rats. PLoS ONE. 2013;8(8):e72610.
  14. Scarfì S. Use of bone morphogenetic proteins in mesenchymal stem cell stimulation of cartilage and bone repair. World Journal of Stem Cells. 2016;8(1):1.
  15. Wen Y, Jiang W, Yang H, Shi J. Exploratory meta-analysis on dose-related efficacy and complications of rhBMP-2 in anterior cervical discectomy and fusion: 1,539,021 cases from 2003 to 2017 studies. Journal of Orthopaedic Translation. 2020;24:166-174.
  16. Cha J, Song Y, Kim S, Thoma D, Jung U, Jung R. Core Ossification of Bone Morphogenetic Protein-2-Loaded Collagenated Bone Mineral in the Sinus. Tissue Engineering Part A. 2021;27(13-14):905-913.
  17. Dang L, Lee K. Effect of bone morphogenetic protein-2/hydroxyapatite on ankle fusion with bone defect in a rabbit model: a pilot study. Journal of Orthopaedic Surgery and Research. 2020;15(1).
  18. Chenard K, Teven C, He T, Reid R. Bone Morphogenetic Proteins in Craniofacial Surgery: Current Techniques, Clinical Experiences, and the Future of Personalized Stem Cell Therapy. Journal of Biomedicine and Biotechnology. 2012;2012:1-14.
  19. Fallucco M, Carstens M. Primary Reconstruction of Alveolar Clefts Using Recombinant Human Bone Morphogenic Protein-2. Journal of Craniofacial Surgery. 2009;20(8):1759-1764.
  20. Clokie C, George S. Reconstruction of 10 major mandibular defects using bioimplants containing BMP-7. Reconstruction of 10 major mandibular defects using bioimplants containing BMP-7. 2008;74(1):67-72.

How to Cite

Sanjaya, I. G. P. H., & Sri Maliawan. (2022). The role of Bone Morphogenetic Protein-2 in craniofacial osteogenesis: A literature review. Intisari Sains Medis, 13(2), 390–392.




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